Use of physical barriers for delayed adjustable strabismus surgery: the effect of interceed and polyglactin 910 mesh.

Hwang, Jeong Min; Chang, Bong Leen

doi:10.1136/bjo.80.8.759

Cited by 19 publications

(17 citation statements)

References 15 publications

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“…These adhesions are normally located between the muscle whose sheath was ruptured and the scleral surface, conjunctiva, Tenon's capsule or orbital fat, leading to cicatricial strabismus. 13,14 Several procedures to prevent these undesired cicatricial events have been proposed and include physical barriers such as a gelatinous sponge obtained from animal skin, 8,15 synthetic peptides, 16 polyglactin 910-based materials, 17 viscoelastic substances, Tenon's capsule, and silicone. 18 The use of antifibrotic drugs such as mitomycin C, 13,17,19,20 daunorubicin, 19 bleomycin, 19 mitramycin, 19 5-fluorouracil, 21 and cyanoacrylate 18 has also been suggested.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 Several procedures to prevent these undesired cicatricial events have been proposed and include physical barriers such as a gelatinous sponge obtained from animal skin, 8,15 synthetic peptides, 16 polyglactin 910-based materials, 17 viscoelastic substances, Tenon's capsule, and silicone. 18 The use of antifibrotic drugs such as mitomycin C, 13,17,19,20 daunorubicin, 19 bleomycin, 19 mitramycin, 19 5-fluorouracil, 21 and cyanoacrylate 18 has also been suggested. Mitomycin C, isolated by Wakaki et al 22 through the fermentation of Streptomyces caespitasus, was classified as an antibiotic and antineoplastic agent able to inhibit DNA, RNA and protein synthesis, cause partial impairment of fibroblast proliferation, and promote degradation of preformed DNA promoting cell nuclear lysis.…”

Section: Introductionmentioning

confidence: 99%

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Use of topical mitomycin C in myoplasty of the medial rectus muscle of rabbits

Mamede

Laus

Cabral

et al. 2004

Veterinary Ophthalmology

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To possibly reduce postoperative adhesions that occur after ocular myoplasties, we investigated the topical effects of 0.04% mitomycin C on the repaired areas of the medial rectus muscle using an equine renal capsule preserved in 98% glycerin for reinforcement of the sutures. Twenty-four rabbits, divided into two groups of 12 animals each [untreated (control) and treated group (MMC)], were submitted to surgical rupture of the medial rectus muscle of one eye and repair of the defect 24 h later with sutures and an equine renal capsule. Post-operative prophylactic treatment of the two groups consisted of the administration of eye drops containing neomycin, polymyxin B and dexamethasone at regular 6-h intervals for eight consecutive days and daily rinsing with physiological saline. MMC animals received additional treatment with topical 0.04% mitomycin C every 6 h for 14 consecutive days. Slit lamp biomicroscopy showed greater irritation of the ocular surface in MMC animals during the first days post operatively. Adhesions were observed at 15 and 30 days of assessment in the two groups, but were more extensive in control animals at 60 days. Histopathology revealed inflammatory exudation in both groups, which was greater in MMC animals. Mitomycin C (0.04%) instilled at 6-h intervals for 14 consecutive days reduced the occurrence of fibrosis in the myoplastic areas. However, the equine renal capsule was found to be of little benefit for the reinforcement of myoplasties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of topical mitomycin C in myoplasty of the medial rectus muscle of rabbits

Mamede

Laus

Cabral

et al. 2004

Veterinary Ophthalmology

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“…After that, researchers tried absorbable mechanical barriers. For this purpose, polydioxanone, polytetrafluoroethylene, Seprafilm, polyglactin 910 sheath, SurgiWrap, and sodium hyaluronate and hydroxypropyl methylcellulose among viscoelastic materials have been used (8)(9)(10)(11)(12)(13)(14). Complications such as foreign body reaction and infection have been encountered minimally with these materials; however, their efficacy against adhesion formation was found to be inadequate.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of mitomycin-C and infliximab in reducing adhesionand fibrosis following strabismus surgery*

Güçlü¹,

Sari

Dinç

et al. 2016

Turk J Med Sci

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IntroductionAdhesion, fibrosis, and scarring formation following strabismus surgery are among the most important problems that unfavorably influence surgical success. The exact incidence of scars, adhesion, and fibrosis has not been reported but Ludwig retrospectively reviewed 134 reoperations in which a stretched scar was discovered and estimated that stretched scar tissue was a contributing factor in 10% of all strabismus reoperations and 50% of late overcorrections (1). Adhesion is the attachment that occurs in some tissues including the conjunctiva, Tenon's capsule, the intermuscular membrane, orbital adipose tissue, the sclera, and extraocular muscular tissue due to any reason during or after strabismus surgery. These adhesions may result from inappropriate surgical approach, excessive bleeding, cautery usage, suture reaction, postoperative infection, muscular capsule injury, migration of adipose tissue to the surgical area due to the laceration of the orbital septum, and multiple procedures performed in the same region (2). Fibrosis is the contracture occurring after inflammation of extraocular muscles. Appropriate surgical techniques should be performed to avoid postoperative adhesion and fibrosis and subsequent scarring (2,3).Adhesion, fibrosis, and scar formation after strabismus surgery bring along unfavorable consequences for both the patient and the surgeon. Need for a second surgery not only psychologically influences the patient negatively but also leads to further tissue injury during the second intervention and causes additional expense. Reducing adhesion, fibrosis, and scarring after strabismus surgery would provide results that are more satisfactory for both patients and surgeons by enhancing anatomical success. For this purpose, many materials and drugs have been studied in experimental or clinical trials; nevertheless, no Background/aim: The present study aimed to investigate the efficacy of mitomycin-C (MMC) and infliximab (INF) in reducing adhesion and fibrosis following strabismus surgery. Materials and methods:Forty eyes of 20 albino rabbits were separated into MMC and INF groups. Right and left eyes of rabbits were assigned to the drug and control groups, respectively. The superior rectus muscle was disinserted, the drug was administered to the surgical area for 5 min in the drug eyes (MMC 0.2 mg/mL or INF 5 mg/mL), and physiological saline was administered to the control eyes. Surgical areas were rinsed with 10 mL of physiological saline. The disinserted muscle was then sutured to the same area using 6.0 Vicryl. The rabbits were sacrificed after 4 weeks for histopathological examination.Results: Significant reduction was observed in fibrosis in the INF group as compared to the control group (P = 0.005). Although adhesion formation in the drug eyes reduced in the MMC and INF groups as compared to the control group, the difference was not significant (P = 0.280 and P = 0.579, respectively). Conclusion:This study demonstrated the fibrosis-preventing efficacy of IFN; thus, it can be a good o...

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“…Efforts have been made to facilitate delayed adjustment by implanting physical barriers such as silicone, 5,6 viscoelastic material, 7 oxidized regenerated cellulose compound (InterceedTC7; Johnson & Johnson Medical, Arlington, Texas), 8 polyglactin 910 mesh, 8 polytetrafluoroethylene (PTFE; W.L. Gore & Associates, Flagstaff, AZ), 9 or bioresorbable sheet (SurgiWrap; MacroPore Biosurgery, Inc, San Diego, CA), 10 by using antiproliferative agents such as mitomycin C, 11 or by using combinations of these various physical barriers and antiproliferative agents.…”

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confidence: 99%