Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw

Bocanegra-Pérez, Sacramento; Vicente-Barrero, Mario; Knežević, Milan; Castellano-Navarro, José María; Rodríguez-Bocanegra, Eduardo; Rodríguez-Millares, J.; Pérez-Plasencia, Daniel; Ramos‐Macías, Ángel

doi:10.1016/j.ijom.2012.04.020

Cited by 64 publications

(51 citation statements)

References 26 publications

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“…In our first case, the patient was in stage 2 and this treatment plan (local debridement, sequestrectomy, use of antibiotics, daily chlorhexidine mouth rinsing) was performed successfully. Several different adjunctive treatments (ie, hyperbaric oxygen [47,48], parathyroid hormone [49], platelet-rich plasma [50], laser [51,52], ozone therapy [53]) have been advocated to improve healing in BRONJ, but their benefits remain to be clarified.…”

Section: Discussionmentioning

confidence: 99%

Bisphosphonate-related osteonecrosis of the jaws: Report of two cases with breast cancer, a dental concern and review of the literature

Şekerci¹,

Şahman²,

Ulu³

et al. 2012

Biodiscovery

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Section: Discussionmentioning

confidence: 99%

Bisphosphonate-related osteonecrosis of the jaws: Report of two cases with breast cancer, a dental concern and review of the literature

Şekerci¹,

Şahman²,

Ulu³

et al. 2012

Biodiscovery

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“…Platelet gels has also shown successful reconstructive result in the post-resection cases of jaws, alveolar clefts and established fistulas within maxillofacial region [41]. James et al [13] reported his work on 15 patients who were treated for alveolar ridge and sinus augmentation by using FDBA along with PRP gel formed by autologous thrombin and concluded by histological and radiographic reports that there was sufficient formation of bone around the implants.…”

Section: Hard Tissue Regenerationmentioning

confidence: 99%

Efficacy of Blood and Its Products-boon for Oral Surgeons: Review

Fareed¹,

Tandon²,

Z³

et al. 2017

J Univer Surg

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A set of scientific researches has focused its attention on discussing the possibility that platelet derivatives are not only coherent for haemostasis, but also have gained popularity in the field of tissue healing. Products obtained from whole blood as a result of centrifugation have wide applications in this field. Various materials are commercially available that are used locally to achieve haemostasis; however platelets and fibrinogen are the natural blood components that exists as a source in coagulation process. Platelets carry platelet-derived growth factors which, when introduced into an injured region, may stimulate a healing response through the recruitment of stem cells, increased vascularization and the production of collagen enhancing both soft and hard tissue healing. Injection of collected venous blood could be a scaffold for new bone formation which is helpful in restricting mouth opening in TMJ subluxation. Injections are inexpensive, simple to acquire, accord minimal trauma with minimal risk for allergic reactions. The purpose of this paper is to provide collective information regarding the various centrifuged products obtained from blood and their application in different ways.

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“…It contains growth factors that might accelerate epithelial wound healing, decrease tissue inflammation after surgery, improve regeneration of bone and soft tissues, and promote tissue vascularization (30). Several studies indicated positive and successful outcome after adding PRP in BRONJ treatment (31)(32)(33)(34).…”

Section: C a Bmentioning

confidence: 99%

Bisphosphonate-related osteonecrosis of jaws in advanced stage breast cancer was detected from bone scan: a case report

et al. 2017

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Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw

Cited by 64 publications

References 26 publications

Bisphosphonate-related osteonecrosis of the jaws: Report of two cases with breast cancer, a dental concern and review of the literature

Bisphosphonate-related osteonecrosis of the jaws: Report of two cases with breast cancer, a dental concern and review of the literature

Efficacy of Blood and Its Products-boon for Oral Surgeons: Review

Bisphosphonate-related osteonecrosis of jaws in advanced stage breast cancer was detected from bone scan: a case report

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