Use of pro‐atrial natriuretic peptide in the detection of myocardial ischaemia

Bocek, T.; Morgenthaler, Nils G.; Staub, Daniel; Nusbaumer, Charly; Christ, Andreas; Zellweger, Michael J.; Müeller-Brand, Jan; Müeller, Beat; Perruchoud, André P.; Müeller, Christian

doi:10.1111/j.1365-2362.2005.01517.x

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…Elevated troponin-T and NT-proBNP confirmed significant ventricular injury in these animals compared to all other groups. These markers are released mainly from the cardiac ventricle [36,37]. The rise in plasma potassium levels in TDG also may indicate that myocardial damage and metabolic acidosis during the early phase of ischemia/reperfusion recovery, are potentiated in these animals [38].…”

Section: Discussionmentioning

confidence: 99%

High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats

et al. 2010

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Perinatal taurine depletion and high sugar diets blunted baroreflex function and heightens sympathetic nerve activity in adult rats. Cardiac ischemia/reperfusion also produces these disorders and taurine treatment appears to improve these effects. This study tests the hypothesis that perinatal taurine exposure predisposes recovery from reperfusion injury in rats on either a basal or high sugar diet. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS) or water alone (control, C) from conception to weaning. Male offspring were fed normal rat chow and water containing 5% glucose (G) or water alone (W) throughout the experiment. At 7-8 weeks of age, all rats were anesthetized and their trachea clamped until cardiac arrest occurred and mean arterial pressure fell below 60 mm Hg. The clamp was immediately released and cardiopulmonary resuscitation was performed with cardiac function returning within 4 min. Twenty-four hours later, arterial pressure, heart rate, and baroreflex function were measured in conscious and one day later in anesthetized conditions. Basic blood chemistry and circulating markers of cardiac injury were also measured. Baroreflex sensitivity was depressed moderately in CG and TDW, and severely in TDG. TSW displayed increased baroreflex and high sugar intake returned it to CW. Sympathetic nerve activity increased and parasympathetic decreased in TDW but not TSW and these effects were exacerbated sharply in TDG and slightly in TSG. Arterial pressure and heart rate increased in all groups but to a lesser degree in TDG. Plasma aspartate aminotransferase increased in all groups except TSW, but the increase was nearly 3X greater in TDG vs. any other group. Creatine kinase-MB increased in all groups except TSG and was far greater in TD than other groups. Troponin-T and brain natriuretic peptide were greatly increased in TDG compared to all other groups. Thus, perinatal taurine depletion increases injury from cardiac ischemia/reperfusion, and in adult rats on a high sugar diet, these effects are greatly exacerbated.

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Section: Discussionmentioning

confidence: 99%

High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats

et al. 2010

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Plasma atrial natriuretic peptide concentration in warmblood horses with heart valve regurgitations

Gehlen

Sundermann

Rohn

et al. 2007

Journal of Veterinary Cardiology

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Evaluation of Circulating Adipokines and Abdominal Obesity as Predictors of Significant Myocardial Ischemia Using Gated Single-Photon Emission Computed Tomography

Hung

Huang

et al. 2014

PLoS ONE

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ObjectiveCoronary artery disease (CAD) is associated with abdominal obesity and metabolic syndrome. Adipocytes secrete adipokines, including the newly discovered adipocyte fatty acid binding protein (A-FABP) and chemerin. Adipokines contribute to the pathogenesis of CAD. In patients with CAD, the presence of significant ischemia predicts adverse outcomes. It is unknown whether adipokines can be better predictors of the presence of significant myocardial ischemia than conventional risk factors. This study aimed to compare adipokines with clinical risk factors and abdominal obesity as predictive factors for significant myocardial ischemia.MethodsOne hundred and ninety-six adults with suspected, but unproven, CAD were consecutively enrolled. The main measures were clinical and biochemical parameters and stress myocardial perfusion imaging with gated myocardial perfusion single-photon emission computed tomography (SPECT), with computed tomography (CT) attenuation correction. The abdominal visceral fat area was examined using a hybrid SPECT/CT scanner. Serum levels of high-sensitivity C-reactive protein (hs-CRP) and adipokines (adiponectin, A-FABP, and chemerin) were evaluated.ResultsA-FABP levels correlated significantly with adiponectin, hs-CRP, body mass index, waist circumference, and visceral fat area. A-FABP was significantly associated with metabolic syndrome (OR 3.2, 95% CI 1.6–6.4, p = 0.001), significant myocardial ischemia (OR 1.9, 95% CI 1.0–3.4, p = 0.05), and stress lung-to-heart ratio (β = 0.03, p = 0.03) on SPECT. Chemerin was significantly associated with serum triglyceride levels but not with metabolic syndrome, significant ischemia, or stress lung-to-heart ratio on SPECT. A-FABP was better at detecting significant inducible ischemia than other biomarkers, although this was a modest improvement (area under ROC curve 0.579, 95% CI 0.46–0.69).ConclusionsSerum A-FABP concentrations correlate significantly with visceral fat area, metabolic syndrome, and predicted significant myocardial ischemia on SPECT. This may help to more accurately assess CAD risk, especially in patients with metabolic syndrome.

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Use of pro‐atrial natriuretic peptide in the detection of myocardial ischaemia

Cited by 3 publications

References 46 publications

High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats

High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats

Plasma atrial natriuretic peptide concentration in warmblood horses with heart valve regurgitations

Evaluation of Circulating Adipokines and Abdominal Obesity as Predictors of Significant Myocardial Ischemia Using Gated Single-Photon Emission Computed Tomography

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