Use of proton pump inhibitors and risk of rosacea: A nationwide population‐based study

Abstract

Proton pump inhibitors (PPI) are commonly used drugs. However, little is known about the association between PPI use and rosacea. This study aimed to investigate the association between PPI use and rosacea risk. Patients with prior PPI therapy, including 1067 rosacea cases and 4268 matched controls, were identified from the National Health Insurance Research Database in Taiwan. The cumulative defined daily dose (cDDD) was used to quantify the PPI use. Logistic regression was used for the analyses. After adjustment for potential confounders, PPI use with cDDD of more than 365 was significantly associated with an increased risk of rosacea (odds ratio [OR], 1.54; 95% confidence interval [CI], 1.10-2.15). Rosacea risk was significantly associated with PPI use of cDDD of more than 365 in women (OR, 1.62; 95% CI, 1.08-2.46) but not in men. Stratified by PPI indications, risk of rosacea was significantly associated with PPI use of cDDD of more than 365 for peptic ulcer (OR, 1.58; 95% CI, 1.12-2.21). In conclusion, prolonged PPI use was associated with an increased risk of rosacea, particularly in women and patients with peptic ulcers.

Effect and Safety of ALA-PDT Combined with 1550 nm Fractional Therapy Laser in Treating Rosacea

“…Rosacea is a common chronic inflammatory skin disease and is mostly found in people aged 30 to 50 years. It usually appears on the face, especially on the cheeks [ 1 ]. Rosacea is divided into telangiectasia rosacea (type I), papulopustular rosacea (type II), hyperplastic granulomatous rosacea (type III), and ocular rosacea (type IV), among which type I and type II are more common [ 2 ].…”

Bidirectional association between alopecia areata and atopic dermatitis: A population‐based cohort study in Taiwan

“…Before the data were released to the researchers, the identification numbers of the participants were encrypted to protect individual privacy. The NHIRD data have been used widely for research 18‐26 . The diagnostic codes used were based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD‐9‐CM).…”

“…The NHIRD data have been used widely for research. [18][19][20][21][22][23][24][25][26] The diagnostic codes used were based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM).…”

Posttraumatic Stress Disorder and the Associated Risk of Autoimmune Skin Diseases: A Nationwide Population-Based Cohort Study

“…The NHI Research Database (NHIRD) contains comprehensive information on the insured participants, including demographic details (date of birth, sex, and residential location) and details of insurance claims (outpatient and inpatient care, medical diagnoses, prescriptions, and operations). The NHIRD data have been widely used in numerous epidemiological studies (32)(33)(34)(35)(36)(37)(38). To protect individual privacy, a unique identification number is assigned to each beneficiary and enciphered before the data are released for scientific purposes.…”