Use of proximal and distal cues in place navigation by mice changes during ontogeny

Chapillon, Pierre

doi:10.1002/(sici)1098-2302(199609)29:6<529::aid-dev5>3.0.co;2-o

Cited by 44 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results using a direct nematode infection of pregnant mice are consistent with these latter studies in that offspring sex did not affect spatial exploration by offspring in the OFT, their ability to retain object location memories in the OLT, or to learn or remember the escape location in the BMT. Similarly, in the absence of maternal stress, no difference in the spatial behaviour and memory performance was observed between male and female pre-weaned (PD 17–18) CD-1 mice and rats in an OFT and OLT 18 , 55 , nor between juvenile (PD 22) male and female mice in a Morris water maze test 60 .…”

Section: Discussionmentioning

confidence: 92%

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Noel

Fortin-Hamel

Haque

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The developing brain is particularly vulnerable to factors including maternal infection during pregnancy. Establishment of neural networks critical for memory and cognition begins during the perinatal period, when Heligmosomoides bakeri, a gastrointestinal (GI) nematode restricted to the maternal mouse intestine, has been shown to upregulate expression of long-term potentiation genes in the young rodent pup brain. We explored the impact of maternal infection during pregnancy and early lactation on the spatial behavior of uninfected male and female juvenile mice. Pre-weaned pups of H. bakeri infected dams exhibited less exploratory behaviour compared to pups of uninfected dams on postnatal day (PD) 16 but not PD 17, possibly reflecting a transient fear of an unfamiliar environment and/or a brief neurodevelopmental delay. Our two spatial memory tests show for the first time an enhancement of spatial memory in response to maternal nematode infection regardless of pup sex. At PD 17, pups of infected dams expressed object location memories after 3 h in the Object Location Test whereas offspring of uninfected mothers did not. In addition, at PD 34, juveniles of infected mothers retained their ability to find the escape hole in the Barnes Maze Test for one week whereas offspring from uninfected mothers did not. This finding is even more striking given that spatial memory was positively associated with pup length, yet this maternal infection impaired linear growth of pups. Thus, the positive impact of maternal infection on spatial memory countered any impairment associated with the shorter length of the pups. Overall, these novel findings indicate that a maternal GI nematode infection during pregnancy and lactation positively influences the spatial memory of uninfected juvenile offspring with potential fitness implications for the next generation.

show abstract

Section: Discussionmentioning

confidence: 92%

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Noel

Fortin-Hamel

Haque

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…However, there are other cases of apparent failure of beacons to interfere with place learning. In mice, the presence of a beacon facilitates learning the location of the dry platform in a water maze (Chapillon & Roullet, 1996). Lavanex and Schenk (1995) reported comparable results for rats finding food.…”

Section: Discussionmentioning

confidence: 98%

Competition among spatial cues in a naturalistic food-carrying task

Gibson

Shettleworth

2003

Learning & Behavior

View full text Add to dashboard Cite

Rats collected nuts from a container in a large arena in four experiments testing how learning about a beacon or cue at a goal interacts with learning about other spatial cues (place learning). Place learning was quick, with little evidence of competition from the beacon (Experiments 1 and 2). Rats trained to approach a beacon regardless of its location were subsequently impaired when the well-learned beacon was removed and other spatial cues identified the location of the goal (Experiment 3). The competition between beacon and place cues reflected learned irrelevance for place cues (Experiment 4). The findings differ from those of some studies of associative interactions between cue and place learning in other paradigms.

show abstract

“…After weaning, different tests measure more complex forms of learning including spatial learning and spatial competencies (Chapillon et al . 1995; Chapillon & Roullet 1996; Paylor et al . 1996; Ricceri et al .…”

Section: The Study Of Behavior During Ontogenymentioning

confidence: 99%

Transgenic and knock‐out mouse pups: the growing need for behavioral analysis

Branchi¹,

Ricceri²

2002

Genes Brain and Behavior

View full text Add to dashboard Cite

Few laboratories working with transgenic and knockout mice analyze the neurobehavioral consequences of genetic manipulation in early ontogeny. However, the study of behavioral endpoints during the early postnatal period in genetically modified mice is important not only to assess possible developmental abnormalities, but also to better understand and disentangle the effects of genetic manipulations in adulthood. We propose that the assessment of neurobehavioral development represents an appropriate strategy to identify possible compensatory and/or unexpected effects. Nowadays, a large number of experimental protocols that take into account the practical constraints imposed by the peculiar physiological and behavioral responses of an immature subject are available to assess the neurobehavioral profile of developing mice. While this knowledge should be applied to the field of transgenic and knock-out mice in general, it should be recommended, in particular, for the study of mouse models of neurodevelopmental disorders.

show abstract

Use of proximal and distal cues in place navigation by mice changes during ontogeny

Cited by 44 publications

References 25 publications

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups

Competition among spatial cues in a naturalistic food-carrying task

Transgenic and knock‐out mouse pups: the growing need for behavioral analysis

Contact Info

Product

Resources

About