Use of Pyridine as Cocatalyst for the Synthesis of 2-Carboxy Substituted Diphenylethers by Ullmann-Goldberg Condensation

Synthesis and cancer cell cytotoxicity of substituted xanthenes

“…The organic layer was dried with MgSO 4 , and concentrated in vacuo to afford desired product (0. 22 …”

“…19,20 Here, we describe the synthesis of a series of substituted xanthenes using a modified Ullmann-Goldberg reaction commonly used in the synthesis of acridones and acridines. 21,22 The approach couples phenols to aryl halides in the presence of copper to generate aryl ethers. Cyclization to the xanthone is then accomplished via Friedel-Crafts-like acylation.…”

2-(m-Tolyloxy)benzoic acid

“…For related structures, see: Shi et al (2011); Raghunathan et al (1982); Zhang (2011). For the synthesis of the title compound, see: Pellon et al (1995). For bond-length data, see: Allen et al (1987).…”

“…The author gratefully acknowledges financial support from the Scientific Research Foundation for High-Level Personnel, Yulin University (11 GK03) and the Collaboration Programs of Yulin City and Universities and thanks Professor Hua-Qin Wang of the Analysis Center, Nanjing University, for providing the Enraf-Nonius CAD-4 diffractometer and data set for this research project. xanthones, p-dibenzo-furans, and p-dibenzo-dioxines (Pellon, et al, 1995). Knowledge of the crystal structure of such benzoic acid derivatives gives us not only information about nuclearity of the complex molecule, but is important in understanding the behaviour of these compounds with respect to the mechanisms of pharmacological activities and physiological activities.…”

Magnetically recyclable nano copper/chitosan in O‐arylation of phenols with aryl halides

“…The CS itself is applied in industry, biomedicine, pharmaceuticals, metal chelating, food processing, etc . Diaryl ethers have many useful applications, and are prepared using Ullmann synthesis through reaction of aryl halides with sodium or potassium aryl oxides catalyzed by copper reagents . This procedure has several drawbacks, such as elevated temperatures and stoichiometric amounts of copper.…”