Use of Reticulated Hyaluronic Acid Alone or Associated With Ozone Gas in the Treatment of Osteoarthritis Due to Hip Dysplasia in Dogs

Júnior, José I. S. Silva; Rahal, S. C.; Santos, Ivan Felismino Charas dos; Martins, Denizar Cruz; Michelon, Fernanda; Mamprim, Maria Jaqueline; Tomacheuski, Rubia Mitalli; Correia, Luiz Eduardo Cruz dos Santos

doi:10.3389/fvets.2020.00265

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…In the United Kingdom alone, 200,000 new cases of OA are diagnosed in dogs annually, with both external (injury, obesity, age) and genetic factors contributing (1,4,5). At present, the disease is treated symptomatically by regularly administering non-steroidal anti-inflammatory drugs or by repeated injections of hyaluronic acid (6,7). Surgical solutions such as arthrodesis or excision arthroplasty (e.g., total joint replacement) are also used in more severe cases (8).…”

Section: Introductionmentioning

confidence: 99%

A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up

Kriston-Pál¹,

Haracska

Cooper³

et al. 2020

Front. Vet. Sci.

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Mesenchymal stem cells (MSC) are emerging as an effective therapeutic tool in treating canine osteoarthritis (OA). In this report, we focused on the questions of whether MSC transplantation has long-term beneficial effects for the improvement in motion and also evaluated the safety of MSC injection. Visceral adipose tissue, a surgical waste obtained during routine ovariectomy served as a source of allogeneic MSCs and used to treat OA. Altogether, fifty-eight dogs were transplanted in the study suffering from OA in the elbow (42 animals), hip (5), knee (8), ankle (2), and hock (1). The effect of MSC transplantation was evaluated by the degree of lameness at a 4-5-years follow-up period based on the owners' subjective observations. The results showed that 83% of the OA patients improved or retained improvement in lameness. Clinical safety of the treatment was assessed by evaluating the coincidence of tumors or other diseases and other adverse reactions (such as local inflammation) after MSC cell therapy. Two incidences of local inflammation for <1 week at the site of injection were reported. No other adverse reactions were detected post-treatment. Sixteen dogs died during the study, 4 due to cancer and 12 due to other diseases, diagnosed by veterinarians. Overall, our survey suggests that MSC transplantation has long-term beneficial effects in reducing lameness. Moreover, no enrichment in a specific cause of death was observed in the transplanted animals, compared to reported literature. Our data suggest that MSC treatment could be an effective and safe long-term therapy for canine OA.

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Section: Introductionmentioning

confidence: 99%

A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up

Kriston-Pál¹,

Haracska

Cooper³

et al. 2020

Front. Vet. Sci.

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“…Recent animal experiments have shown that hip dysplasia and other joint abnormalities may be a consequence of hyaluronic acid deficiency in synovial fluids [45] [46]. It has also been shown that the intra-articular hyaluronic acid implementation alone or associated with ozone allowed improvement of hip dysplasia in animal model [47]. The role of hyaluronic acid is found to be crucial according to both regression models describing the connection between innate immunity and connective tissue as well as between some connective tissue parameters.…”

Section: Discussionmentioning

confidence: 97%

Innate Immunity in the Development of Connective Tissue Dysplasia: Pilot Study in Children with Congenital Hip Dislocation

Yazykova¹,

Musikhina²,

Vlasov³

et al. 2022

JBM

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Introduction: Observing and treatment of hip dysplasia in children have always been in the sphere of interest of modern molecular medicine. The role of molecular factors in the formation of connective tissue dysplasia in children is considered crucial for such multisystem disorders, and connective tissue dysplasia progressing involves immune system parameters and biochemical markers. The aim of this work was to establish the relationship between immune status indicators and biochemical markers of connective tissue using bioinformatics and modeling methods. Materials and Methods: 27 patients with congenital hip dislocation, admitted to the University Clinic of Privolzhsky Research Medical University, Department of children orthopedics for surgical treatment, were examined. Determination of 10 blood parameters was conducted by modern biochemical and immunological methods. Statistica 12.0 software from StatSoft was used for statistical data processing. Methods of nonparametric statistics were used since the samples in the control group partially follow the normal distribution. Correlation methods and regression modeling methods were used to evaluate the relationship of indicators. Results and Conclusion: In our investigation we have shown the presence of statistical and mathematical interactions between the parameters of innate immunity and indicators of connective tissue metabolism. The leading role of the immune system in the development of pathologies associated with connective tissue dysplasia is assumed. In further investigations it is necessary to clarify the role hypoxia in HIF-1 stimulated control of skeletal dysplasia, collagen modification, connective tissue dysplasia development.

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“…Hence, recent advances have suggested a novel therapy with anti-nerve growth factor monoclonal antibodies as a replacement for traditional analgesics [ 120 , 121 ]. Furthermore, intra-articular administration of hyaluronan [ 122 , 123 ], corticosteroids [ 122 ], platelet-rich plasma [ 124 ], or ozone gas [ 123 ] are also considered an alternative when controlling joint pain and inflammation. In addition, the wide range of early mechanical conservative options available in humans, lack in dogs.…”

Section: Main Textmentioning

confidence: 99%

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

Tomé,

Alves-Pimenta,

Sargo

et al. 2023

BMC Vet Res

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Human and veterinary medicine have historically presented many medical areas of potential synergy and convergence. Mechanical osteoarthritis (MOA) is characterized by a gradual complex imbalance between cartilage production, loss, and derangement. Any joint instability that results in an abnormal overload of the joint surface can trigger MOA. As MOA has a prevailing mechanical aetiology, treatment effectiveness can only be accomplished if altered joint mechanics and mechanosensitive pathways are normalized and restored. Otherwise, the inflammatory cascade of osteoarthritis will be initiated, and the changes may become irreversible. The management of the disease using non-steroidal anti-inflammatory drugs, analgesics, physical therapy, diet changes, or nutraceuticals is conservative and less effective. MOA is a determinant factor for the development of hip dysplasia in both humans and dogs. Hip dysplasia is a hereditary disease with a high incidence and, therefore, of great clinical importance due to the associated discomfort and significant functional limitations. Furthermore, on account of analogous human and canine hip dysplasia disease and under the One Medicine concept, unifying veterinary and human research could improve the well-being and health of both species, increasing the acknowledgement of shared diseases. Great success has been accomplished in humans regarding preventive conservative management of hip dysplasia and following One Medicine concept, similar measures would benefit dogs. Moreover, animal models have long been used to better understand the different diseases’ mechanisms. Current research in animal models was addressed and the role of rabbit models in pathophysiologic studies and of the dog as a spontaneous animal model were highlighted, denoting the inexistence of rabbit functional models to investigate therapeutic approaches in hip MOA.

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Use of Reticulated Hyaluronic Acid Alone or Associated With Ozone Gas in the Treatment of Osteoarthritis Due to Hip Dysplasia in Dogs

Cited by 9 publications

References 36 publications

A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up

A Regenerative Approach to Canine Osteoarthritis Using Allogeneic, Adipose-Derived Mesenchymal Stem Cells. Safety Results of a Long-Term Follow-Up

Innate Immunity in the Development of Connective Tissue Dysplasia: Pilot Study in Children with Congenital Hip Dislocation

Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review

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