Use of serum C-reactive protein as an early marker of inflammatory activity in canine type II immune-mediated polyarthritis: case report

Kjelgaard‐Hansen, Mads; Jensen, A. L.; Houser, Geoffrey A; Jessen, Lisbeth Rem; Kristensen, Annemarie T.

doi:10.1186/1751-0147-48-9

Cited by 30 publications

(44 citation statements)

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“…The present data confirmed the hypothesis that canine serum CRP allows the differentiation of variable degrees of inflammatory activity initiated by 3 different standard elective aseptic soft‐tissue surgical procedures. This further supports the use of canine serum CRP as a quantitative marker of systemic inflammation . Whether canine serum CRP would also qualify as an inflammation monitoring marker in clinical settings remains to be tested in similar studies with a more extensive postsurgical follow‐up period.…”

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confidence: 52%

“…A general ability to quantitatively reflect the level of systemic inflammatory activity would support a general clinical use of canine CRP not just to detect inflammatory activity but also to quantify and monitor systemic inflammatory activity, as exemplified in a report on comparison of 2 treatment regimens for IBD, treatment of experimentally induced bacterial cystitis, and in 2 case reports on management of type II immune‐mediated polyarthritis and pyogranuloma in dogs, respectively. However, further evidence is necessary to support the quantitative diagnostic potential of CRP.…”

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confidence: 99%

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Canine serum C‐reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery

Kjelgaard‐Hansen

Strøm

Mikkelsen

et al. 2013

Veterinary Clinical Pathol

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confidence: 52%

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confidence: 99%

Canine serum C‐reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery

Kjelgaard‐Hansen

Strøm

Mikkelsen

et al. 2013

Veterinary Clinical Pathol

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“…Although arthritis has been described in dogs experimentally infected with Borrelia burgdorferi [44, 45], and infection with Anaplasma phagocytophilum has been suspected to cause immune-mediated polyarthritis [22], it is often difficult to establish causality between infection and arthritis in a clinical setting which is why determination of a single antibody titre is considered to be of limited diagnostic value. All healthy dogs in this study were seronegative, which could be explained by the fact that they were purpose bred research dogs and most of them had not been exposed to ticks.…”

Section: Discussionmentioning

confidence: 99%

“…C-reactive protein has the advantages of being an objective, quantitative marker of inflammation [17] that is not biased by treatment with non-steroidal anti-inflammatory drugs (NSAID) [18–20] or glucocorticoids [21]. This is in contrast to other markers of systemic inflammation such as fever and evaluation of the leukogram [21, 22]. Because serum CRP concentrations have been reported to be substantially elevated in suppurative arthritis [23, 24], but not in OA [25, 26], our hypothesis was that this marker should help differentiate between these two conditions.…”

Section: Introductionmentioning

confidence: 99%

Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs

et al. 2016

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BackgroundIn a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations.MethodsDogs with joint pain were enrolled prospectively and were classified to have suppurative arthritis or OA based on synovial fluid analysis and radiographic/arthroscopic findings. Healthy Beagles were enrolled as a comparative group. CRP and IL-6 concentrations were measured with canine-specific immunoassays. The performance of CRP concentration in discriminating between dogs with suppurative arthritis and OA was evaluated using a previously established clinical decision limit for CRP (20 mg/l), and by receiver operator characteristic (ROC) curve and logistic regression analysis. Comparisons of CRP and IL-6 concentrations between groups were performed using t-tests, and correlations by Spearman rank correlation coefficients.ResultsSamples were obtained from 31 dogs with suppurative arthritis, 34 dogs with OA, and 17 healthy dogs. Sixty-two out of 65 dogs with joint disease were correctly classified using the clinical decision limit for CRP. Evaluation of ROC curve and regression analysis indicated that serum CRP concentrations could discriminate between suppurative arthritis and OA. Dogs with suppurative arthritis had higher serum CRP and serum and synovial fluid IL-6 concentrations compared to dogs with OA (p < 0.001). Dogs with OA had higher synovial fluid IL-6 concentrations (p < 0.001), but not higher serum CRP (p = 0.29) or serum IL-6 (p = 0.07) concentrations, compared to healthy dogs. There was a positive correlation between synovial fluid IL-6 and serum CRP concentrations (rs = 0.733, p < 0.001), and between serum IL-6 and serum CRP concentrations (rs = 0.729, p < 0.001).ConclusionCRP concentration was found to discriminate well between dogs with suppurative arthritis and OA.

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“…CRP is a quantitative marker of inflammation [10], and its measurement is used to monitor disease activity in dogs with immune-mediated polyarthritis [11, 12]. Despite being a reliable marker of systemic inflammation, CRP concentrations in human SLE correlate inconsistently with disease activity.…”

Section: Resultsmentioning

confidence: 99%

Serum C-reactive protein concentrations in Nova Scotia Duck Tolling Retrievers with immune-mediated rheumatic disease

et al. 2017

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Nova Scotia Duck Tolling Retrievers (NSDTRs) are a dog breed often affected by immune-mediated rheumatic disease (IMRD), a disorder characterised by chronic stiffness and joint pain. Most, but not all, dogs with IMRD, have antinuclear antibodies (ANA), which are also commonly present in the autoimmune disease systemic lupus erythematosus (SLE). The clinical and diagnostic findings of IMRD indicate that it is an SLE-related disorder. C-reactive protein (CRP), an acute phase protein, is a quantitative marker of inflammation for many diseases and is used for diagnosing and monitoring systemic inflammation in both humans and dogs. However, in human SLE, CRP concentrations are often elevated but correlate poorly with disease activity; they can be low in individual patients with active disease. The aim of the study was to investigate CRP in a group of NSDTRs with the SLE-related disorder IMRD. The hypothesis was that CRP concentrations would be increased in dogs with IMRD compared to healthy dogs, but that the increase would be mild. Serum CRP concentrations were measured in 18 IMRD-affected NSDTRs and 19 healthy control NSDTRs using two different canine-specific CRP assays. Dogs with IMRD and ANA had higher CRP concentrations than the control dogs, but the concentrations were below the clinical decision limit for systemic inflammation for most of the IMRD dogs. These results indicate that CRP concentrations were increased in dogs with IMRD and ANA, but the increase was mild, similar to what has been observed in human SLE.

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Use of serum C-reactive protein as an early marker of inflammatory activity in canine type II immune-mediated polyarthritis: case report

Abstract: Background: Monitoring systemic inflammatory activity during steroid therapy of canine immunemediated polyarthritis (IMPA) is difficult and mainly relies on clinical signs.

Cited by 30 publications

References 14 publications

Canine serum C‐reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery

Canine serum C‐reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery

Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs

Serum C-reactive protein concentrations in Nova Scotia Duck Tolling Retrievers with immune-mediated rheumatic disease

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