Use of Silicone Elastomer-Based Microfluidic Devices and Systems in Reproductive Technologies

Matsuura, Koji; Naruse, Keiji

doi:10.5772/47731

Cited by 2 publications

(2 citation statements)

References 85 publications

(114 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Millet and co-workers [22] discarded platinum impetus, un-cross-linked oligomers, and soluble factors constantly by using extractions of local PDMS with different solvent components. Figure 2 shows PDMS-based microfluidic devices for embryo culture [23].…”

Section: Non-specific Assimilationmentioning

confidence: 99%

Microfluidics Engineering: Recent Trends, Valorization, and Applications

2017

View full text Add to dashboard Cite

In recent years, microfluidics engineering has gained increasing research interests in assimilation and designing novel constructs for various application in bio-and non-bio sectors of the modern world. Soft and photo-lithographic fabricated devices have a potential to control the diffusion and flow of liquids in channels. The fabricated microfluidic devices of unique geometry facilitate excellent control over extracellular microenvironment and soluble factor interactions. The current devices do not only replace the in-vitro approaches but also provide a new understanding of biomolecules separation and flow in the network of microchannels. The appropriate physiological responses of cells in biological studies or drug screening analysis require engineering of active cells outside the body to enhance their maximum potential for best cellular therapy. This review work mainly focuses on the current methodologies involved in the fabrication process and limitations of cell array technology. The information is given on considerable advantages of microfluidic devices. Towards the end, potential applications covering microfluidic-based in-vitro drug analysis and analytical-based separation/detachment are discussed with potential future viewpoints.

show abstract

Section: Non-specific Assimilationmentioning

confidence: 99%

Microfluidics Engineering: Recent Trends, Valorization, and Applications

2017

View full text Add to dashboard Cite

show abstract

“…There are many challenges to address when creating microphysiological models, such as finding a common media that provides the appropriate nourishment for each organ in the system, designing accurate microfluidics between organs, and providing the necessary substrate(s) for the production of signaling molecules. 1 Although progress has been made in recapitulating individual reproductive organs, 107,108 there are currently no models of the reproductive system as a whole. However, technology developed for modeling other anatomical systems could be modified for development of a repro-on-a-chip system.…”

Section: Sex-specific Modulation Of Hepatic Functionmentioning

confidence: 99%

Microphysiological modeling of the reproductive tract: A fertile endeavor

Eddie

Kim

Woodruff

et al. 2014

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Preclinical toxicity testing in animal models is a cornerstone of the drug development process, yet it is often unable to predict adverse effects and tolerability issues in human subjects. Species-specific responses to investigational drugs has led researchers to utilize human tissues and cells to better estimate human toxicity. Unfortunately, human cell-derived models are imperfect because toxicity is assessed in isolation, removed from the normal physiologic microenvironment. Microphysiological modeling, often referred to as ‘organ-on-a-chip’ or ‘human-on-a-chip’ places human tissue into a microfluidic system that mimics the complexity of human in vivo physiology, thereby allowing for toxicity testing on several cell types, tissues, and organs within a more biologically relevant environment. Here we describe important concepts when developing a repro-on-a-chip model. The development of female and male reproductive microfluidic systems is critical to sex-based in vitro toxicity and drug testing. This review addresses the biological and physiological aspects of the male and female reproductive systems in vivo and what should be considered when designing a microphysiological human-on-a-chip model. Additionally, interactions between the reproductive tract and other systems are explored, focusing on the impact of factors and hormones produced by the reproductive tract and disease pathophysiology.

show abstract

Use of Silicone Elastomer-Based Microfluidic Devices and Systems in Reproductive Technologies

Cited by 2 publications

References 85 publications

Microfluidics Engineering: Recent Trends, Valorization, and Applications

Microfluidics Engineering: Recent Trends, Valorization, and Applications

Microphysiological modeling of the reproductive tract: A fertile endeavor

Contact Info

Product

Resources

About