Use of Sublingual Immunotherapy for Aeroallergens in Children with Asthma

Abstract

Asthma is a heterogeneous disease that in children is often allergen-driven with a type 2 inflammation. Sublingual immunotherapy represents an important progress in the use of personalized medicine in children with allergic asthma. It is a viable option for house dust mite-driven asthma and in subjects with the asthma associated with allergic rhinitis. The use and indications for isolated asthma caused by other allergens are still controversial owing to heterogeneity of commercially available products and methodological limitations of studies in children. Nevertheless, most studies and meta-analyses found the efficacy of sublingual immunotherapy. Sublingual immunotherapy is safe but cannot be recommended in children with uncontrolled asthma.

Hypersensitivity to Intravenous Iron Preparations

“…Allergen immunotherapy using the oral route has been shown to be of benefit in children with an allergy to inhalants and foods [ 48 , 49 , 50 ], but, so far, it has not been investigated in drug HSRs. Delayed reactions to iron are rare.…”

Allergen-specific immunotherapy in allergic rhinitis

“…Существует по крайней мере пять способов введения аллергенов при АСИТ: подкожный [7-9], подъязычный [10][11][12], оральный [13][14][15], эпикутанный [16,17] и внутрилимфатический [18,19]. В настоящее время документировано и апробировано два пути введения аллергенов для применения в практике: подкожный [7] и подъязычный [10].…”

“…Таблетки и капли вводятся под язык и держатся до проглатывания или выплевываются. Потенциал подъязычной АСИТ обусловлен безопасностью и низким риском системных побочных реакций, достижением долгосрочного клинического эффекта и отсутствием необходимости частого посещения медицинского учреждения и консультирования у аллерголога [10,11]. Поэтому лечение может быстро претерпевать изменения в составе аллергенов, если это потребуется.…”

New insights in pediatrics in 2021: choices in allergy and immunology, critical care, endocrinology, gastroenterology, genetics, haematology, infectious diseases, neonatology, neurology, nutrition, palliative care, respiratory tract illnesses and telemedicine

“…The allergic asthma is often associated with atopic diseases [ 1 ] with eosinophil inflammation [ 2 , 3 ] acidification [ 4 ] and oxidative stress [ 5 ] in the airways. Allergen immunotherapy, both subcutaneous immunotherapy and sublingual immunotherapy, remains the only effective treatment for IgE-mediated allergic rhinoconjunctivitis and asthma [ 6 ]. It has also been used in skin diseases [ 7 ].…”