Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges

Guigou, Caroline; Lalande, Alain; Millot, Nadine; Belharet, Karim; Grayeli, Alexis Bozorg

doi:10.3390/brainsci11030358

Cited by 26 publications

(15 citation statements)

References 150 publications

(420 reference statements)

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“…In recent years, much attention has been paid to nanoparticles as drug carriers, because they can serve as a drug delivery system due to controlling and slowing the release of drugs, smaller particle size than cells, biocompatibility, and increasing the therapeutic efficacy of drugs (24). Therefore, nanotechnology has been very effective in the evolution of drug delivery, and materials such as nanocarriers are known to be very effective in diagnosing and treating a variety of diseases with higher benefits than conventional methods (25).…”

Section: Discussionmentioning

confidence: 99%

Comparison between direct use and PLGA nanocapsules containing drug of traditional Chinese medicine, Tiaojing Zhixue, in treatment of dysfunctional uterine bleeding

Han

Wang

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Dysfunctional uterine bleeding is menstrual bleeding in abnormal volume, duration, or time, and it is a common problem in women. A wide range of drug therapies, with varying efficacy, is available for women with dysfunctional uterine bleeding. The use of herbal and traditional medicine is one of the ways to treat this disease, which has fewer side effects than chemical drugs. On the other hand, these medicines have less effect on treatment than chemical drugs. Therefore, increasing their effectiveness in the treatment of diseases has always been important. For this purpose, in this study, a comparison was done between direct use and PLGA nanocapsules containing Tiaojing Zhixue, in the treatment of dysfunctional uterine bleeding. First, PLGA nanocapsules containing Tiaojing Zhixue were synthesized by the electrospray technique. Then 80 women with dysfunctional uterine bleeding were treated with this medicine. These people were divided into two groups of 40 people. The first group was treated with 20mg of Tiaojing Zhixue and the other group was treated with PLGA nanocapsules containing Tiaojing Zhixue for eight months. The duration and frequency of bleeding from one month before the start of treatment and during the eight months after the start of treatment (second, fourth, and eighth month) were assessed in two groups. The two groups were homogeneous in terms of mean frequency of bleeding and mean duration of bleeding before starting treatment. The positive response in the PLGA nanocapsules treatment group (75%) was higher than the direct use drug treatment group (42.5%) (P < 0.01). The rate of side effects was the same in each group. Due to the effectiveness of PLGA nanocapsules in the treatment of dysfunctional uterine bleeding and the lack of side effects, it can be considered as an alternative medicine for the treatment of this disorder.

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Section: Discussionmentioning

confidence: 99%

Comparison between direct use and PLGA nanocapsules containing drug of traditional Chinese medicine, Tiaojing Zhixue, in treatment of dysfunctional uterine bleeding

Han

Wang

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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“…The most commonly used local administration method is intratympanic drug injection [ 59 , 60 , 61 ]. When using this technique, the drug enters the middle ear cavity and must remain there for a sufficient time to pass through the round or oval window and reach the inner ear [ 61 , 62 , 63 ].…”

Section: Administration Routesmentioning

confidence: 99%

“…Superparamagnetic iron oxide nanoparticles (SPIONs) are another promising strategy as they can be magnetically guided across the round window and precisely reach the targeted inner ear structures [ 13 , 56 , 59 ]. Moreover, their relatively simple synthesis, low toxicity, intrinsic antimicrobial activity, and functionalization ability are very important properties for designing effective biocompatible nanoplatforms [ 98 ].…”

Section: Nanoparticles-mediated Treatmentmentioning

confidence: 99%

Nanoparticles for the Treatment of Inner Ear Infections

et al. 2021

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The inner ear is sensitive to various infections of viral, bacterial, or fungal origin, which, if left untreated, may lead to hearing loss or progress through the temporal bone and cause intracranial infectious complications. Due to its isolated location, the inner ear is difficult to treat, imposing an acute need for improving current therapeutic approaches. A solution for enhancing antimicrobial treatment performance is the use of nanoparticles. Different inorganic, lipidic, and polymeric-based such particles have been designed, tested, and proven successful in the controlled delivery of medication, improving drug internalization by the targeted cells while reducing the systemic side effects. This paper makes a general presentation of common inner ear infections and therapeutics administration routes, further focusing on newly developed nanoparticle-mediated treatments.

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“…Superparamagnetic Fe 3 O 4 nanoparticles are a kind of inorganic material. These materials could pass the round window by magnetic force and arrive at the inner ear (Guigou et al, 2021 ). Superparamagnetic iron oxide nanoparticles are easy to synthesize and exhibit low toxicity and intrinsic antimicrobial activity for effective delivery systems (Rodrigues et al, 2019 ).…”

Section: Nanoparticle-based Drug Delivery Systems For Inner Ear Disease Therapymentioning

confidence: 99%

Nanocarriers for Inner Ear Disease Therapy

Zheng

et al. 2021

Front. Cell. Neurosci.

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Hearing loss is a common disease due to sensory loss caused by the diseases in the inner ear. The development of delivery systems for inner ear disease therapy is important to achieve high efficiency and reduce side effects. Currently, traditional drug delivery systems exhibit the potential to be used for inner ear disease therapy, but there are still some drawbacks. As nanotechnology is developing these years, one of the solutions is to develop nanoparticle-based delivery systems for inner ear disease therapy. Various nanoparticles, such as soft material and inorganic-based nanoparticles, have been designed, tested, and showed controlled delivery of drugs, improved targeting property to specific cells, and reduced systemic side effects. In this review, we summarized recent progress in nanocarriers for inner ear disease therapy. This review provides useful information on developing promising nanocarriers for the efficient treatment of inner ear diseases and for further clinical applications for inner ear disease therapy.

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Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges

Cited by 26 publications

References 150 publications

Comparison between direct use and PLGA nanocapsules containing drug of traditional Chinese medicine, Tiaojing Zhixue, in treatment of dysfunctional uterine bleeding

Comparison between direct use and PLGA nanocapsules containing drug of traditional Chinese medicine, Tiaojing Zhixue, in treatment of dysfunctional uterine bleeding

Nanoparticles for the Treatment of Inner Ear Infections

Nanocarriers for Inner Ear Disease Therapy

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