Local anesthesia has certain harm to the patient, and the wrong position of the anesthesia point may result in poor anesthesia effect. Based on this, this study built an automatic positioning recognition model based on ultrasound image guidance technology. At the same time, this paper combined the actual requirements of anesthesia to establish a wireless positioning system based on ultrasonic infrared, and the system combined ultrasonic propagation characteristics and sensing receiving characteristics. In addition, in the study, this article combined with the state of the anesthesia point to take ultrasound-guided anesthesia. Finally, this paper designed a comparative experiment to study the performance of automatic positioning of anesthesia points based on ultrasound image guidance technology and collected actual data to analyze. Studies have shown that the method proposed in this study has certain clinical effects and can provide theoretical references for subsequent related research.