Use of the Burden of Diabetes Mellitus Score for Cardiovascular Disease Risk Assessment

Farjo, Peter; Barghouthi, Nadia; Chima, Noor; Desai, Anand; Fang, Wei; Giordano, Jennifer; Bianco, Christopher

doi:10.1016/j.amjcard.2020.03.027

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…Hyperglycemia facilitates the formation of advanced glycation end products (AGEs), which cross-links with extracellular matrix proteins, leading to increased fibrosis, elevated myocardial stiffness (MS), impaired myocardial relaxation and diastolic dysfunction, and eventually heart failure (3)(4)(5). Increased myocardial stiffness is an independent and significant risk factor in diastolic dysfunction (6)(7)(8). Thus, early detection of MS is strategic; however, methods assessing MS in diabetes remain poorly studied.…”

Section: Introductionmentioning

confidence: 99%

Exploring the prospect of intrinsic wave propagation in evaluating myocardial stiffness among patients with type 2 diabetes

Cheng,

Huang,

Fan

et al. 2023

Front. Cardiovasc. Med.

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BackgroundDiabetes predisposes affected individuals to impaired myocardial perfusion and ischemia, leading to cardiac dysfunction. Increased myocardial stiffness is an independent and significant risk factor in diastolic dysfunction. This study sought to estimate myocardial stiffness in Type 2 diabetes (T2DM) patients using the intrinsic wave velocity propagation (IVP) along the longitudinal wall motion during late diastole and evaluate the value of IVP in assessing cardiac function and structure.Methods87 and 53 participants with and without T2DM (control group) were enrolled. Of the 87 T2DM patients (DM group), 43 were complicated with hypertension (DM + H group), and 44 were not (DM-H group). Ultrasound parameters were measured and analyzed, including color M-mode flow propagation velocity, global longitudinal systolic strain (GLS), and IVP.ResultsIVP was higher in the DM group than in the control group (1.62 ± 0.25 m/s and 1.40 ± 0.19 m/s, P < 0.001). After stratification for hypertension, IVP in both DM + H (1.71 ± 0.25 m/s) and DM-H (1.53 ± 0.20 m/s) groups were found to be significantly higher than that in the control group (1.40 ± 0.19 m/s); also, the difference of IVP between DM + H and DM-H group reached statistical significance. Moreover, IVP was significantly correlated with flow propagation velocity during early diastole (Pve) (r = −0.580, P < 0.001), flow propagation velocity during late diastole (Pva) (r = 0.271, P < 0.001), GLS (r = 0.330, P < 0.001), interventricular septal thickness at end-diastole (IVSd) (r = 0.321, P < 0.001), blood glucose (r = 0.246, P < 0.003), systolic blood pressure (r = 0.370, P < 0.001) and diastolic blood pressure (r = 0.389, P < 0.001).ConclusionsThe results indicated the application potential of IVP in assessing the early detection of cardiac function changes noninvasively and sensitively. The correlation with myocardial stiffness warrants further studies to substantiate its potential clinical utility.

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Section: Introductionmentioning

confidence: 99%

Exploring the prospect of intrinsic wave propagation in evaluating myocardial stiffness among patients with type 2 diabetes

Cheng,

Huang,

Fan

et al. 2023

Front. Cardiovasc. Med.

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“…Cardiovascular disease (CVD) is the leading cause of death in diabetic patients (Stehouwer et al, 2008). Diabetes mellitus (DM) is an independent predictor for cardiovascular adverse events (Farjo et al, 2020). Their mechanisms are still not fully understood, but it is believed that increased arterial stiffness is an important mechanism linking diabetes to increased cardiovascular risk (Safar, 1996).…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus, hypertension, and HbA1c, as risk factors for arterial stiffness

Regla

Okawa

Oliveira

et al. 2022

Preprint

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Studies in a healthy and diabetic population have shown that there is a correlation between the disease and arterial stiffness, and consequently an increase in Pulse Wave Velocity (PWV). We investigate predictors laboratory and clinical associated with arterial stiffness, validated by the increase in PWV. Our findings showed that the predictor for diabetes mellitus, hypertension, glycated hemoglobin ≥5.7, confirmed the significant association for increased arterial stiffness, validated by the increase in PWV.

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Section: Introductionmentioning

confidence: 99%

“…The association between diabetes and a marked increase in the risk of coronary heart disease is well-established [1,2]. Although many factors are involved in the development of atherosclerosis and coronary heart disease, the two most important are hyperglycemia and insulin resistance [2,3]. There is growing evidence that the generation of oxidative stress and inflammation that occurs during postprandial hyperglycemia is an important mechanism for the initiation and progression of endothelial dysfunction in type 2 diabetes [3,4].…”

Section: Introductionmentioning

confidence: 99%

High β-Glucan Barley Improves Postprandial Hyperglycemia after Meal Loading in Patients with Type 2 Diabetes

Fuse¹,

Higa²,

Fujitani³

et al. 2021

austinjnutrmetab

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Objective: We investigated whether barley with a high β-glucan content (7.2 g per 100 g) improves postprandial plasma glucose levels and fluctuations using a meal tolerance test and Continuous Glucose Monitoring (CGM) in patients with type 2 diabetes. Methods: A meal tolerance test (500 kcal) was conducted using two types of test meals: one with white rice (WR diet) and one with white rice mixed 1:1 with high β-glucan-containing barley (BR diet). Both meals included the same side dish. Plasma glucose changes over 180 minutes were compared after ingestion of the test meals. In addition, participants wore a CGM device for the 2 study days, to measure the daily variations in glucose levels when the WR or BR diet as staple food was provided 3 times a day with the same side dish in both meals. Results: Twenty-nine patients with type 2 diabetes (age 52.5 ± 15.1 years, BMI 27.5 ± 4.7 kg/m2, HbA1c 8.1 ±1.8 %) were included in this study. The incremental area under the curve of plasma glucose levels after BR diet ingestion was significantly lower than that after WR diet ingestion (7934.0 ± 4151.2 vs 9434.0 ± 4701.2 mg·min/dL). CGM showed a 24-hour standard deviation of blood glucose after the BR diet was significantly lower than that after the WR diet. Conclusion: These results suggest that postprandial plasma glucose elevation and fluctuation in patients with type 2 diabetes are suppressed by adding high-β-glucan barley to white rice in meals.

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Use of the Burden of Diabetes Mellitus Score for Cardiovascular Disease Risk Assessment

Cited by 4 publications

References 27 publications

Exploring the prospect of intrinsic wave propagation in evaluating myocardial stiffness among patients with type 2 diabetes

Exploring the prospect of intrinsic wave propagation in evaluating myocardial stiffness among patients with type 2 diabetes

Diabetes mellitus, hypertension, and HbA1c, as risk factors for arterial stiffness

High β-Glucan Barley Improves Postprandial Hyperglycemia after Meal Loading in Patients with Type 2 Diabetes

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