Use of the Continuous Glucose Monitoring System in Goettingen Minipigs, With a Special Focus on the Evaluation of Insulin-Dependent Diabetes

Strauss, Armin; Tiurbe, Christian; Chodnevskaja, Irina; Thiede, A.; Timm, S.; Ulrichs, K.; Moskalenko, Vasiliy

doi:10.1016/j.transproceed.2008.02.003

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…To our knowledge, its use in swine has only been reported by us [25]; the present data confirm and add to our previous results. Once again only measurements are used where the correlation of interstitial glucose and serum glucose levels was > 90%.…”

Section: Discussionsupporting

confidence: 92%

“…RTGM , a system developed to monitor glucose levels in human diabetics, had been successfully used on GMP by our group [25]. We applied it in two further GMP models.…”

Section: Resultsmentioning

confidence: 99%

“…The CGMS ® (Medtronic MiniMed; Northridge, USA) continuous glucose monitoring system was used as described by us previously [25]. …”

Section: Methodsmentioning

confidence: 99%

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Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes

Strauss

Moskalenko

Tiurbe

et al. 2012

Diabetol Metab Syndr

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PurposePreclinical experiments on large animals are indispensable for evaluating the effectiveness of diabetes therapies. Miniature swine are well suited for such studies due to their physiological and pathophysiological responses.MethodsWe compare two methods for inducing diabetes in Goettingen minipigs (GMP), in five with the beta cell toxin streptozotocin (STZ) and in five other GMP by total pancreatectomy (PE). Glucose homeostasis was assessed with the intravenous glucose-tolerance test (IVGTT) and continual monitoring of interstitial glucose levels. At conclusion of the observation period, the pancreata were examined histologically. Three non-diabetic GMP served as control group.ResultsThe IVGTT revealed markedly diabetic profiles in both GMP groups. STZ-GMP were found to harbor residual C-peptides and scattered insulin-positive cells in the pancreas. PE-GMP survived the total pancreatectomy only with intensive postoperative care.ConclusionsAlthough both methods reliably induced diabetes in GMP, the PE-GMP clearly had more health problems and required a greater expenditure of time and resources. The PE-GMP model, however, was better at eliminating endogenous insulin and C-peptide than the STZ-GMP model.

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Section: Discussionsupporting

confidence: 92%

“…RTGM , a system developed to monitor glucose levels in human diabetics, had been successfully used on GMP by our group [25]. We applied it in two further GMP models.…”

Section: Resultsmentioning

confidence: 99%

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Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes

Strauss

Moskalenko

Tiurbe

et al. 2012

Diabetol Metab Syndr

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“…However, additional refinement could optimize animal welfare and accurate study results. Surgical implantation of continuous glucose monitors and glucose telemetry has been previously validated, 14,26,36 however, surgical manipulations may be undesirable or overly invasive for some study designs.…”

mentioning

confidence: 99%

Assessment of a Noninvasive Chronic Glucose Monitoring System in Euglycemic and Diabetic Swine (Sus scrofa)

Ober¹,

Geist²

2020

j am assoc lab anim sci

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Models of type-I diabetes are well-characterized and commonly used in the preclinical evaluation of drugs and medical devices. The diabetic minipig is an excellent example of a translational model. However, chronic glucose monitoring in this species can be challenging; frequent blood sampling can be technically difficult and poorly tolerated in conscious swine. Skin-patch continuous blood glucose monitors are FDA-approved for human use and offer a potential refinement to cageside blood collection. However, this modality has not been evaluated in pigs. In this study, young adult male STZ-induced diabetic Yucatan minipigs (n = 4) and healthy York pigs (n = 4) were implanted with a 14-d skin-patch continuous glucose monitor. Readings from continuous glucose monitors were time-matched to whole blood samples, with glucose measurements performed using point-of-care blood glucose monitors, serum chemistry or both. The aims of the study were to assess if a continuous glucose monitoring system could accurately detect glucose levels in swine, and to compare the readings toboth point-of-care glucometers and serum chemistry results. We hypothesized that a continuous glucose monitoring system would accurately detect glucose levels in swine in comparison with a validated analyzer and could serve as an animal welfarerefinement for studies of diabetes. We found that the continuous glucose monitor used in this study provided an adequateadjunct for clinical management in the stable diabetic pig and a minimally invasive and inexpensive option for colony maintenanceof chronically diabetic swine.

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trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro

Guschlbauer

Klinger

Burmester

et al. 2013

Comparative Biochemistry and Physiology Part A: Molecular &

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Use of the Continuous Glucose Monitoring System in Goettingen Minipigs, With a Special Focus on the Evaluation of Insulin-Dependent Diabetes

Cited by 4 publications

References 4 publications

Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes

Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes

Assessment of a Noninvasive Chronic Glucose Monitoring System in Euglycemic and Diabetic Swine (Sus scrofa)

trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro

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