2001
DOI: 10.1002/ijc.10174
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Use of the human MDR1 promoter for heat‐inducible expression of therapeutic genes

Abstract: The promoter of the human multidrug resistance gene (mdr1) harbors stress-responsive elements, which can be induced e.g., by heat or cytostatic drugs. In previous studies the drug-responsiveness of the mdr1 promoter was successfully used for the drug-inducible expression of the human TNF-␣ gene in vitro and in vivo. Beside the drug-responsive elements of the mdr1 promoter, heat-shock responsive elements have also been identified, which could be exploited for construction of heat-inducible expression vectors. T… Show more

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Cited by 18 publications
(1 citation statement)
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“…capable of destroying a tumour), but are currently limited by systemic toxicity would benefit. Hyperthermia has thus been suggested as a non-invasive and non-toxic method of inducing gene expression locally using a thermoinducible promotor [45]. There have been studies describing inducible gene expression systems in which thermal energy was used to activate gene expression.…”
Section: Hyperthermiamentioning
confidence: 99%
“…capable of destroying a tumour), but are currently limited by systemic toxicity would benefit. Hyperthermia has thus been suggested as a non-invasive and non-toxic method of inducing gene expression locally using a thermoinducible promotor [45]. There have been studies describing inducible gene expression systems in which thermal energy was used to activate gene expression.…”
Section: Hyperthermiamentioning
confidence: 99%