Use of the lactose-ethanol tolerance test in diabetes

MacDonald, Michael J.; Horowitz, Ralph; Duncan, Theodore G.

doi:10.1097/00000441-197503000-00005

Cited by 7 publications

(4 citation statements)

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“…If glucose metabolism is delayed, falla ciously high blood glucose concentrations may occur in lactose malabsorbers with consequential false negative test results [25]. Comparative studies in a triracial community in Singapore revealed that glycos uria and 'latent' diabetes mellitus are more common in Asiatic Indians than in Chinese, Malays or Euro peans [26].…”

Section: Glucose Metabolismmentioning

confidence: 99%

Prevalence of Primary Adult Lactose Malabsorption in Pakistan

Siddique¹,

Flatz²

1984

Hum Hered

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Lactose absorption capacity was examined in 414 apparently healthy, adult Pakistani subjects. In a subgroup of 44 subjects, the lactose tolerance test was performed using both blood glucose and breath hydrogen determination. The remaining 370 probands were examined using a field version of the breath hydrogen test. In the total sample of 414 probands, 248 lactose malsabsorbers were indentifíed (60%). This result differs considerably from previous reports of very low frequencies of lactose malabsorption in Pakistan and neighbouring areas.

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Section: Glucose Metabolismmentioning

confidence: 99%

Prevalence of Primary Adult Lactose Malabsorption in Pakistan

Siddique¹,

Flatz²

1984

Hum Hered

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“…Little though is known on the prevalance of lactose malab sorption in diabetics and only the LTT-Gal has been studied in this group of patients [5]. The principal conclusions from the analysis of our data are the following.…”

Section: Discussionmentioning

confidence: 79%

“…This cause of abdominal symp toms is one of the differential diagnoses to be considered also in diabetic patients when diabetic enteropathy [4] is suspected. The only indirect test, independent of jejunal in tubation, which has been evaluated so far in a diabetic population [5] is the lactose toler ance test with sequential serum galactose measurements (LTT-Gal). This test requires prior oral alcohol ingestion to suppress rapid galactose turnover into glucose by the liver.…”

mentioning

confidence: 99%

Concordance of Indirect Methods for the Detection of Lactose Malabsorption in Diabetic and Nondiabetic Subjects

et al. 1991

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In order to collect data on (1) the prevalence of lactose malabsorption and (2) the value of indirect diagnostic methods for hypolactasia in diabetics, we compared lactose tolerance tests using serum glucose, serum galactose (after oral ethanol intake) and breath hydrogen excretion as diagnostic cutoff in 144 nondiabetic and 46 diabetic subjects. A good rate of concordance was found for the hydrogen breath test and galactose-dependent lactose tolerance test. The glucose-dependent lactose tolerance test was found to be of satisfactory diagnostic value in nondiabetic subjects and was useless for diagnostic purposes in diabetics. Lactose malabsorption was no more frequent in diabetics than in controls and lactose intolerance was found to be less frequent in the diabetic group. A distinction between hypolactasia and other gastrointestinal disorders in diabetics is possible by ambulatory indirect tests.

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“…However, it is not Lactose and Cataract in Humans certain that plasma and lens galactitol values vary in the same way. Finally, the "beneficial" effect of glucose on postprandial galactosemia could disappear in diabetic patients, but to our knowledge this has only been assayed in the case of the concomitant ingestion of alcohol [30]. 4.…”

Section: Details Of Lactose and Galactose Metabolism In Manmentioning

confidence: 99%

Lactose and cataract in humans: a review.

Couet

Jan

Debry

1991

Journal of the American College of Nutrition

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In this review, the relationship between lactose and human cataract is examined from the presently available biochemical, metabolic, and epidemiological data. The exceptional cases of homozygous enzyme deficiency being excluded, fragmentary data give reason to believe that a risk of cataract secondary to lactose and galactose ingestion is present in certain subpopulations. In these population groups, the size of which is unknown, the lens could be exposed to intermittent episodes of hypergalactosemia due to the presence of a partial enzyme deficiency in the galactose metabolic pathway, and/or the persistence of a high adult jejunal lactase activity, and/or to a large and repeated consumption of either whole lactose or easily absorbed lactose (hydrolyzed forms and nonpasteurized yogurt).

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Use of the lactose-ethanol tolerance test in diabetes

Cited by 7 publications

References 0 publications

Prevalence of Primary Adult Lactose Malabsorption in Pakistan

Prevalence of Primary Adult Lactose Malabsorption in Pakistan

Concordance of Indirect Methods for the Detection of Lactose Malabsorption in Diabetic and Nondiabetic Subjects

Lactose and cataract in humans: a review.

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