Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan

Chella, Naveen; Shastri, Nalini R.; Tadikonda, Rama Rao

doi:10.1016/j.apsb.2012.07.005

Cited by 81 publications

(41 citation statements)

References 17 publications

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“…After centrifugation, the solutions were filtered through 0.45 µm Millipore filter, diluted with distilled water and analyzed by UV-Visible spectrophotometer (Lab India 1700 UV-Visible spectrophotometer, India) at a wavelength of 214 nm against blank. 15 …”

Section: Solubility Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Enhancement of Loperamide Dissolution Rate by Liquisolid Compact Technique

Venkateswarlu¹,

J²,

Chandrasekhar³

2016

Adv Pharm Bull

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Section: Solubility Studiesmentioning

confidence: 99%

“…The angle of repose was calculated using the following formula, tan α = h/r, α is the angle of repose. 15 …”

Section: Flow Properties Of Liquisolid Powdermentioning

confidence: 99%

Enhancement of Loperamide Dissolution Rate by Liquisolid Compact Technique

Venkateswarlu¹,

J²,

Chandrasekhar³

2016

Adv Pharm Bull

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“…Increasing the moisture content of carrier materials may result in decreased powder flowability [29]. So, PEG 200 was the appropriate solvent in the preparation of lacidipine liquisolid tablets.…”

Section: Saturation Solubility Studiesmentioning

confidence: 99%

Preparation and in Vitro Evaluation of Lacidipine Oral Liquid Solid Tablet as an Approach of Solubility and Dissolution Rate Enhancement

Rajab

2018

Int J App Pharm

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Objective: The aim of the present study was to prepare a new liquid-solid tablet to enhance the dissolution and bioavailability of a poor water soluble calcium channel blocker lacidipine.Methods: Firstly, solubility study of lacidipine in different media of water-miscible non-volatile solvents as tween 20, tween 80, propylene glycol, liquid paraffin, PEG200, PEG400, and PEG600 was investigated to select the most suitable solvent. A mathematical model was applied to calculate the appropriate amount of carrier and coating material.Four liquid-solid tablets of 6 mg lacidipine were prepared by dissolving the drug in the previously chosen water miscible non-volatile solvents, then a binary mixture of the carrier (Avicel PH 102) and coating material (Aerosil 200) at a ratio of 45:1 was used in all preparation since it gave the optimal flow property. Croscarmellose and magnesium stearate were incorporated in all prepared formulas as super disintegrant and lubricant respectively. On the other hand, directly compressed lacidipine tablet of the same previous composition without the addition of any non-volatile solvent was prepared for comparism study. Both characterizations of powder mixture and post-compression tablet evaluations were done. Differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FTIR) were investigated for the pure drug, physical mixture, and selected liquid-solid tablet to exclude any drug-excipients interaction. Results:The obtained results indicated that PEG 200 was the most suitable solvent with lacidipine solubility of 2.81 mg/ml. Flowability of all the prepared formulas was found to be within the specification limits. The liquid-solid tablet formula with PEG 200 at 10% w/w lacidipine was the most suitable one in the term of disintegration time (21±0.2 second), 100% of drug release within 10 min, and with accepted other tablet properties.DSC thermograms for both physical mixture of selected liquisolid system and its tablets illustrated the formation of lacidipine amorphous solid solution. The absence of chemical interaction between drug and other formula components was confirmed by remaining all characteristic peaks of lacidipine in all investigated FTIR spectra. Conclusion:Liquid-solid tablet was considered as a promising system to enhance solubility and dissolution rate of poor-water soluble lacidipine.

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“…It was found that liquisolid tablets exhibited significantly higher drug release rates than conventional tablets and PEG 400 was found to be better in comparison to PG for enhancing the dissolution rate. Chella and his team mates have reported a research on improvement of dissolution rate of valsartan (76). Initially liquisolid compacts were prepared using PG as non volatile solvent, Avicel PH102 as carrier and Aerosil 200 as the coating material.…”

Section: Investigations Reported In 2011mentioning

confidence: 99%