Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis

Lohmander, L. Stefan; Brandt, Kenneth D.; Mazzuca, Steven A.; Katz, Barry P.; Larsson, S.; Struglics, A.; Lane, Kathleen A.

doi:10.1002/art.21345

Cited by 71 publications

(51 citation statements)

References 29 publications

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“…Therefore, it is likely that this mechanism of action contributes to the in vivo anti-inflammatory and anticatabolic effects of CS-GlcN. The baseline MMP-3 level in serum is a significant predictor of joint space narrowing in knee OA [63]. In addition, serum MMP-3 levels in knee OA patients are significantly greater in generalized OA compared with non generalized disease [64].…”

Section: Discussionmentioning

confidence: 99%

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

Terencio

Ferrándiz

Carceller

et al. 2016

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 99%

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

Terencio

Ferrándiz

Carceller

et al. 2016

Biomedicine & Pharmacotherapy

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“…Moreover, MMP-3 levels correlate with erosive disease in RA patients despite the finding of normal CRP levels (52), and associations between MMP-3 gene promoter polymorphisms and radiographic outcome in RA have been described (53)(54)(55). Studies of conditions that are traditionally considered noninflammatory, such as osteoarthritis, have also suggested that MMP-3 levels can predict radiographic joint space narrowing (56). The ability of MMP-3 to act as a proteinase with a broad substrate profile and its ability to activate collagenase support the notion that it plays a complex role in pathologic processes.…”

Section: Young-min Et Almentioning

confidence: 94%

Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers

Young-Min¹,

Cawston²,

Marshall³

et al. 2007

Arthritis & Rheumatism

113

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Objective. To evaluate the performance of biochemical and traditional markers in predicting radiographic progression in rheumatoid arthritis (RA).Methods. One hundred thirty-two patients with early RA were treated with nonbiologic therapies for 2 years and studied longitudinally. Genomic DNA was analyzed for presence of the shared epitope. Conclusion. These results indicate that biochemical markers are useful predictors of radiographic progression in RA and that serum MMP-3 levels decrease significantly with MTX therapy. Multivariate models that include MMP-3 and CTX-II perform better than existing traditional markers in predicting radiographic outcome in RA.

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“…Also interestingly, MMP-3 was found to be increased in plasma shortly after injury, perhaps as a reflection of synovial activation and inflammation [20,21]. Interestingly, plasma levels of MMP-3 were shown to be predictive of knee joint space narrowing over 16 months in a prospective, longitudinal OA clinical trial [22].…”

Section: Introductionmentioning

confidence: 95%

Phonoarthrography, musculoskeletal ultrasonography, and biochemical biomarkers for the evaluation of knee cartilage in osteoarthritis

Bassiouni

El-Deeb

Kenawy³

et al. 2011

Mod Rheumatol

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The aim of this study was to examine the relationship among three different parameters used to assess cartilage in osteoarthritis (OA) of the knee. These parameters are phonoarthrography (Phono-A), musculoskeletal ultrasonography (MSUS) from the 4 condyles, and biochemical markers; notably, matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of proteinase (TIMP-1). A total of 100 knees with chronic idiopathic OA diagnosed according to the American College of Rheumatology (ACR) criteria were studied, together with 50 normal knees. The knee sounds were recorded by Phono-A and the cartilage thickness was measured by MSUS. All patients and controls had MMP-3 and TIMP-1 measured in a blood sample, using an enzyme-linked immunosorbent assay (ELISA). Conventional knee X-rays were obtained for diagnosis and for Kellgren-Lawrence (K-L) grading purposes. The results showed that Phono-A values were inversely correlated with cartilage thickness, both of these being sensitive parameters for cartilage degeneration. Phono-A values were higher in patients than in controls, denoting more degeneration of cartilage, and the cartilage thickness of all 4 condyles showed significant reductions in patients compared with normal controls. Most of the patients were categorized as grade 2 (36%) and grade 3 (30%) of the K-L classification. Mean levels of MMP-3 and TIMP-1 were significantly elevated in both groups but they were not correlated with each other. MMP-3 continued to rise with increasing radiological grades until grade 4, where it fell unexpectedly. In conclusion, Phono-A and cartilage thickness measured by MSUS seem to support each other. They can be used as parameters for following up cartilage in OA of the knees. The first deals with the roughness of the cartilage surface and the second with its thickness, complementing each other. MMP-3 continues to rise in early and middle grades of OA, denoting cartilage destruction.

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Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis

Abstract: Conclusion. The baseline MMP-3 level was a significant predictor of JSN in this pilot study. Moreover, serial plasma MMP-3 levels reflected concurrent JSN in the placebo group over the 30-month period of observation.

Cited by 71 publications

References 29 publications

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers

Phonoarthrography, musculoskeletal ultrasonography, and biochemical biomarkers for the evaluation of knee cartilage in osteoarthritis

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