Use of unlicensed black salve for cutaneous malignancy

Ong, Natalie; Sham, Eric; Adams, Brandon

doi:10.5694/mja14.00041

Cited by 8 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are significant concerns about the effectiveness of black salves. Cases of extensive tissue destruction [ 278 ] and recurrent disease resulting in death have been reported from its use [ 279 ]. Of the two histologically confirmed cases of melanoma treated with black salve, both developed metastatic disease [ 280 , 281 ].…”

Section: Current Uses Of S Canadensismentioning

confidence: 99%

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Croaker

King

Pyne

et al. 2016

IJMS

View full text Add to dashboard Cite

Sanguinaria canadensis, also known as bloodroot, is a traditional medicine used by Native Americans to treat a diverse range of clinical conditions. The plants rhizome contains several alkaloids that individually target multiple molecular processes. These bioactive compounds, mechanistically correlate with the plant’s history of ethnobotanical use. Despite their identification over 50 years ago, the alkaloids of S. canadensis have not been developed into successful therapeutic agents. Instead, they have been associated with clinical toxicities ranging from mouthwash induced leukoplakia to cancer salve necrosis and treatment failure. This review explores the historical use of S. canadensis, the molecular actions of the benzophenanthridine and protopin alkaloids it contains, and explores natural alkaloid variation as a possible rationale for the inconsistent efficacy and toxicities encountered by S. canadensis therapies. Current veterinary and medicinal uses of the plant are studied with an assessment of obstacles to the pharmaceutical development of S. canadensis alkaloid based therapeutics.

show abstract

Section: Current Uses Of S Canadensismentioning

confidence: 99%

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Croaker

King

Pyne

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…For example, the two common constituents of cyanoacrylate-based bioadhesives, namely n-octyl and n-butyl have caused harmful histological changes in pancreatic tissue [106]. Furthermore, other detrimental reactions can occur within the body, such as necrosis and inflammation [107,108]. Other than the cytotoxic environment, cyanoacrylates have further shown that the length of the alkyl group influences the bioadhesives properties.…”

Section: Bioinert Adhesivesmentioning

confidence: 99%

Emerging bioadhesives: from traditional bioactive and bioinert to a new biomimetic protein-based approach

Wanasingha

Dutta

Choudhury

2021

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

“…Black salve is promoted as a safe skin cancer therapy, able to discriminate between cancerous and healthy tissue [ 57 ]. There are concerns about the accuracy of this claim with cases of extensive tissue necrosis reported in the literature from black salve use [ 38 , 58 ]. Two explanations may account for this finding.…”

Section: Black Salve Cancer Specificity and Normal Tissue Toxicitymentioning

confidence: 99%

A Review of Black Salve: Cancer Specificity, Cure, and Cosmesis

Croaker

King

Pyne

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Black salve is a topical escharotic used for the treatment of skin cancer. Although promoted as a safe and effective alternative to conventional management by its proponents, limited clinical research has been undertaken to assess its efficacy and potential toxicities. Patients are increasingly utilizing the Internet as a source of health information. As a minimally regulated space, the quality and accuracy of this information vary considerably. This review explores four health claims made by black salve vendors, investigating its natural therapy credentials, tumour specificity, and equivalence to orthodox medicine in relation to skin cancer cure rates and cosmesis. Based upon an analysis of in vitro constituent cytotoxicity, in vivo post black salve histology, and experience with Mohs paste, black salve is likely to possess normal tissue toxicity with some cancer cell lines being relatively resistant to its effects. This may explain the incongruous case study reports of excessive scarring, deformity, and treatment failure.

show abstract

Use of unlicensed black salve for cutaneous malignancy

Cited by 8 publications

References 2 publications

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses

Emerging bioadhesives: from traditional bioactive and bioinert to a new biomimetic protein-based approach

A Review of Black Salve: Cancer Specificity, Cure, and Cosmesis

Contact Info

Product

Resources

About