Use rate and assisted reproduction technologies outcome of cryopreserved semen from 629 cancer patients

Sperm DNA fragmentation in cryopreserved samples from subjects with different cancers

“…The findings of the present study may contribute to explaining the lower pregnancy rate when cryopreserved semen from cancer patients is used in IVF cycles (Kelleher et al 2001;Lass et al 2001;Ragni et al 2003;Agarwal et al 2004;Chung et al 2004;van Casteren et al 2008). Studies in animals and men demonstrate that DNA-fragmented spermatozoa can fertilise an oocyte and produce viable embryos (Ahmadi and Ng 1999;Fatehi et al 2006;Pérez-Cerezales et al 2010;Yamauchi et al 2012).…”

“…Despite extensive sperm banking, the degree to which cryopreserved semen is used in ART remains low, approaching only 10% (van Casteren et al 2008;Bizet et al 2012;Botchan et al 2013;Ping et al 2014). Consequently, studies on ART outcome using cryopreserved semen from cancer patients suffer from possible bias because of this low rate, with variable results reported (see table 1 in van Casteren et al 2008).…”

“…Despite extensive sperm banking, the degree to which cryopreserved semen is used in ART remains low, approaching only 10% (van Casteren et al 2008;Bizet et al 2012;Botchan et al 2013;Ping et al 2014). Consequently, studies on ART outcome using cryopreserved semen from cancer patients suffer from possible bias because of this low rate, with variable results reported (see table 1 in van Casteren et al 2008). However, the available studies indicate that a lower pregnancy rate is achieved after IVF cycles using cryopreserved spermatozoa of cancer patients (averaging 18%; see table 1 of van Casteren et al 2008) compared with cryopreserved spermatozoa from healthy donors (averaging 39%; Clarke et al 1997;Tomlinson et al 2010;Nordqvist et al 2014).…”

Use of an oncology sperm bank: a Canadian experience

“…[12][13][14][15][16][17] As ART continues to improve, success rates from older studies are not helpful in counselling patients. Patients need up-to-date numbers in order to make informed choices.…”

Oncofertility in Canada: cryopreservation and alternative options for future parenthood

“…Live birth rates were 14.3%, 25%, and 28.3% per cycle for intrauterine insemination, ivf, and icsi respectively, and overall parenthood success rates were 51% per patient (18 of 35) 86 . Other studies have noted parenthood rates of 33%-73% per patient 86 . However, those studies remain largely confounded by the partner's variable response to fertility treatments.…”