“…There does seem to be a consensus on the use of VL prior to performing experiments in a real lab, in order to prepare and train users without space, time and cost constraints (Sypsas and Kalles, 2018;Kurniawati et al, 2019). Some articles reviewed VL APPs for use in Biology, Biotechnology and Chemistry classes, and although they reaffirm that VL must not substitute the real experience lab work, the advantages are best seen when VL is combined with traditional lab practices as they indicate good general cognitive effects in the development of skills and motivation (Cataldi and Dominighini, 2018;Sypsas and Kalles, 2018). Comparatively with the same amount of training time, there is a large increase in student achievement when the traditional methodology is combined with the virtual laboratory and tutoring led by the teacher (Agbonifo et al, 2020).…”