Usefulness and safety of pirenzepine in double-contrast study of upper gastrointestinal tract: Comparison with scopolamine methylbromide

Braccini, G; Marraccini, Paolo; Marrucci, Anna; Boraschi, Piero; Falaschi, Fabio; Testa, Roberto; Bartolozzi, Carlo

doi:10.1007/bf00203506

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Therapeutic doses of antimuscarinics have been used to facilitate hypotonic duodenography, contrast examination of the colon, and in digital subtraction angiography of the aortoiliac region because they decrease bowel movement artifacts [12,13,14,15,16,17], and in abdominal MR examinations [6,9,11,16]. Animal studies have shown that this action is due to a double mechanism: specific anticholinergic (antimuscarinic) activity in the acetylcholine receptor; and a direct effect in the smooth musculature (musculotropic).…”

Section: Discussionmentioning

confidence: 99%

Effect of subcutaneous butylscopolamine administration in the reduction of peristaltic artifacts in 1.5-T MR fast abdominal examinations

et al. 2003

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In abdominal MR imaging, ghost artifacts from noncyclic bowel movements can reduce the quality of the images. Although pharmacologic suppression of motion is effective, no study has being conducted to analyze the influence of drug motion suppression on fast breath-hold 1.5-T examinations of the upper abdomen. A prospective, randomized, doubleblind trial was conducted in 50 patients. Patients were randomly distributed into two groups: The control group received only an oral solution, whereas the other group received the oral solution plus a subcutaneous injection of 20 mg of butylscopolamine 10 min before the MR examination. Breath-hold T1-weighted gradientrecalled-echo (GRE) MR images were obtained in a 1.5-T superconductive unit. Quantitative image analysis was performed with regionof-interest (ROI) measurements of the signal intensity of the liver and in background air anterior and lateral to the patient. A qualitative analysis of the subjective quality of the T1weighted images was also done, and the adverse reactions were registered. The groups were homogeneous regarding age, gender, and weight dis-tribution. No significant differences in the signal intensity of the liver and in the incoherent noise measurements were found between the two groups. Gastrointestinal noise showed significant differences between groups, with lower values for the butylscopolamine group compared with the control group. There was also a statistically significant difference in the image quality between groups, and optimal studies were only found in the butylscopolamine group, where most patients had a good-quality evaluation. Regarding adverse events, there were non-significant differences between groups. In conclusion, administration of an antiperistaltic agent to reduce the movements of the gastrointestinal tract diminishes the motion artifacts generated on MR imaging of the abdomen, even at high field strength and with fast imaging sequences. Images of the upper abdomen obtained after pharmacologic suppression of the gastrointestinal movement are of significantly superior quality.

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Section: Discussionmentioning

confidence: 99%

Effect of subcutaneous butylscopolamine administration in the reduction of peristaltic artifacts in 1.5-T MR fast abdominal examinations

et al. 2003

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Pirenzepine versus scopolamine methyl bromide in double-contrast barium enema study of large bowel

et al. 1996

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To evaluate the usefulness of pirenzepine for diagnostic double-contrast barium enema study of the large bowel, pirenzepine and scopolamine methyl bromide (SMB) were compared in a single, blind, randomized trial. Sixty consecutive patients were enrolled in the study. Quantitative analysis of bowel distention was done by measuring the maximum diameter of the transverse colon before and after drug administration. Four independent observers blindly evaluated distention and mucosal coating of the large bowel and global quality of the images. No differences were found in the diagnostic performance between the two drugs. However, pirenzepine induced a slight but significantly larger distention of the large bowel (68 +/- 12 vs. 65 +/- 8 mm, p = 0.02). Heart rate and rhythm during the study were recorded by ECG. SMB induced tachycardia in all patients (from 72 +/- 15 to 98 +/- 24 beats/min, p < 0.01), whereas pirenzepine did not (from 76 +/- 13 to 78 +/- 20, p = NS). After SMB, one-patient exhibited faintness, and some patients complained of visual accommodation defects, dryness of the mouth, and dizziness. Pirenzepine had a diagnostic performance similar to SMB in avoiding adverse effects elicited by SMB.

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Reduction of peristaltic artifacts on magnetic resonance imaging of the abdomen: a comparative evaluation of three drugs

1996

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Usefulness and safety of pirenzepine in double-contrast study of upper gastrointestinal tract: Comparison with scopolamine methylbromide

Cited by 4 publications

References 8 publications

Effect of subcutaneous butylscopolamine administration in the reduction of peristaltic artifacts in 1.5-T MR fast abdominal examinations

Effect of subcutaneous butylscopolamine administration in the reduction of peristaltic artifacts in 1.5-T MR fast abdominal examinations

Pirenzepine versus scopolamine methyl bromide in double-contrast barium enema study of large bowel

Reduction of peristaltic artifacts on magnetic resonance imaging of the abdomen: a comparative evaluation of three drugs

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