Usefulness of advanced monoenergetic reconstruction technique in dual-energy computed tomography for detecting bladder cancer

Nakagawa, Motoo; Naiki, Taku; Naiki‐Ito, Aya; Ozawa, Yuichi; Shimohira, Masashi; Ohnishi, Masami; Shibamoto, Yuta

doi:10.1007/s11604-021-01195-5

“…The CT sensitivity in the detection of these tumors may be improved by the early enhancement as a diagnostic criterion [85]. Nakagawa et al [86], in fact, analyzed VMI at 40 keV of 52 patients with histological demonstration of bladder cancer in comparison with synthetics 120 kVp reconstructions and demonstrated that, in VMI at 40 keV, the difference in CT number between the cancer and bladder wall was significantly higher and that these images were preferred by the readers with a statistically significant difference.…”

Section: Study Of the Bladder And Uretersmentioning

confidence: 99%

Dual-Energy CT Applications in Urological Diseases

Cellina,

Bausano,

Pais

et al. 2023

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Dual-energy computed tomography (DECT) is a medical imaging technique that uses two different energy levels of X-rays to provide more detailed information about the composition of tissues and materials within the body. DECT technology is still relatively new but different applications have been developed for the urological field. For example, it can be used to analyze the composition of stones to determine whether they are likely to be made up of calcium oxalate, uric acid, or other minerals. This information can help guide treatment decisions, as different types of stones may require different approaches to treatment. The availability of iodine maps helps the differentiation between benign and malignant tumors of the urinary tract, including the bladder, kidneys, and ureters. The iodine maps generated by DECT can provide information on tumor vascularity, which can help in staging and determining the aggressiveness of the tumor. DECT can assess blood flow in the kidneys and detect vascular disorders such as renal artery stenosis or aneurysms. This can be critical for early detection and management of these disorders, which can reduce the risk of renal failure and improve outcomes. DECT is a valuable tool in the urological field that can provide clinicians with detailed and accurate information for the diagnosis and treatment planning of various urological conditions. In this narrative review, we propose an overview of the possible application of DECT in the field of urological diseases.

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“…However, the postoperative recurrence rate is high, up to 50% to 70%, which seriously endangers the life of sufferers. It is of great significance to watch an effective means to appraise the postoperative recurrence of bladder carcinoma for early clinical prevention and treatment and to improve the prognosis of sufferers [ 3 , 4 ]. Nuclear matrix protein 22 (NMP22) is an internal structural component of the nucleus, involved in DNA replication, transcription, and RNA synthesis, and also plays an important regulatory role in gene conveying.…”

Section: Introductionmentioning

confidence: 99%

The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer

Huang

¹

,

Ai²,

Hu

³

et al. 2022

Journal of Immunology Research

0

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Objective. To investigate the value of preoperative urinary nuclear matrix protein 22 (NMP22) and Cystatin B (CSTB) expressions in evaluating the postoperative recurrence of bladder cancer. Methods. The clinical case data of 102 patients with bladder cancer who underwent surgical treatment from January 2017 to January 2022 were collected, and the patients were divided into a recurrence group ( n = 54 ) and nonrecurrence group ( n = 48 ) according to whether the patients recurred after surgery, and the preoperative NMP22 and CSTB expression levels between the two groups were compared. Receiver operating curve (ROC) was used to analyze the evaluation value of preoperative NMP22 and CSTB expression in patients with bladder cancer postoperative recurrence. Logistic multivariate regression method was used to analyze the correlation between preoperative NMP22 and CSTB expression and postoperative bladder cancer recurrence. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of NMP22 and CSTB single detection and combined detection were evaluated for postoperative recurrence of bladder cancer. Results. The preoperative expression levels of NMP22 and CSTB in the recurrence group were significantly higher than those in the nonrecurrence group ( P < 0.05 ). The results of ROC curve analysis showed that the AUC of preoperative NMP22 and CSTB expression levels to assess postoperative recurrence of bladder cancer was 0.696 and 0.659, respectively ( P < 0.05 ). Logistic multivariate regression analysis showed that preoperative NMP22 and CSTB overexpression was an independent risk factor for postoperative recurrence of bladder cancer ( OR = 1.042 , 2.307, P < 0.05 ). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of preoperative NMP22 combined with CSTB in evaluating bladder cancer recurrence after surgery were higher than those of preoperative NMP22 and CSTB alone, and the differences were statistically significant ( P < 0.05 ). Conclusion. Preoperative NMP22 and CSTB conveying is hardly interrelated to postoperative recurrence of bladder carcinoma and has certain appraisal worth for postoperative recurrence of bladder carcinoma, and the combined testing of the two has a taller appraisal worth. NMP22 combined with CSTB detection will help to detect postoperative recurrence of bladder cancer and formulate effective treatment measures in time.

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“…Preoperative diagnosis can improve the accuracy of preoperative staging and detect the recurrence of bladder cancer after operation [ 24 – 26 ]. Conventional CT often uses two-dimensional slice observation, so many spatial data are lost, and the structural and morphological display of cancerous tissue is not complete and sufficient [ 27 ]. Imaging doctors cannot intuitively make accurate and objective judgments based on the observed images, which may lead to wrong diagnosis [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Prognosis Analysis and Perioperative Research of Elderly Patients with Non‐Muscle‐Invasive Bladder Cancer under Computed Tomography Image of Three‐Dimensional Reconstruction Algorithm

Ke

¹

,

Qiu

²

,

Cong

³

2022

Contrast Media & Molecular Imaging

0

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To analyze the application value of computed tomography (CT) based on a three-dimensional reconstruction algorithm in perioperative nursing research and prognosis analysis of non-muscle-invasive bladder cancer (NMIBC), a retrospective study was performed on 124 patients with NMIBC who underwent surgical treatment in the hospital. All patients underwent CT examination based on the three-dimensional reconstruction algorithm before surgery, and transurethral resection of the bladder tumor was performed. The patients receiving conventional care were classified as the control group, and those receiving comprehensive care were classified as the case group, and the recovery status and recurrence of the two groups were compared. The results showed that the accuracy, specificity, and sensitivity of CT imaging information based on the three-dimensional reconstruction algorithm for NMIBC patients were 89.38, 93.77, and 84.39, respectively. The incidence of bladder spasm (9.68%), bladder flushing time (1.56 d), and retention of drainage tube time (2.68 d) in the case group were obviously lower compared with the control group (30.65%, 2.32 d, and 5.19 d) ( P < 0.05). Serum BLCA-1 (3.72 ng/mL) and CYFRA21-1 (5.68 μg/mL) in the case group were significantly lower than those in the control group, with a statistically considerable difference ( P < 0.05). Compared with the control group, the scores of role function (89.82 points), emotional function (84.76 points), somatic function (79.23 points), and social function (73.93 points) in the case group were observably higher ( P < 0.05). In addition, one year after the operation, CT examination showed that the recurrence rate in the case group (6.45%) was significantly lower than that in the control group (22.58%) ( P < 0.05). Therefore, CT detection based on the three-dimensional reconstruction algorithm was particularly important for preoperative diagnosis, prognosis, and recurrence monitoring of NMIBC patients. It could provide great clinical value for the diagnosis and prognosis monitoring of NMIBC.

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Usefulness of advanced monoenergetic reconstruction technique in dual-energy computed tomography for detecting bladder cancer

Cited by 11 publications

References 21 publications

Dual-Energy CT Applications in Urological Diseases

Dual-Energy CT Applications in Urological Diseases

The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer

Prognosis Analysis and Perioperative Research of Elderly Patients with Non‐Muscle‐Invasive Bladder Cancer under Computed Tomography Image of Three‐Dimensional Reconstruction Algorithm

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