Usefulness of blood and cerebrospinal fluid laboratory testing to predict bacterial meningitis in the emergency department

Julián-Jiménez, Agustín; Morales-Casado, María Isabel

doi:10.1016/j.nrleng.2018.05.005

Cited by 13 publications

(8 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CSF lactate concentrations were proved in some studies to be higher in BM than in VM. (93,149,(152)(153)(154) -Sodium concentration Low Na concentrations in the blood of PVM patients were also noted and reported in some studies.…”

Section: -Glucose Concentrationmentioning

confidence: 88%

“…This biochemical property of PVM was not proved to have an absolute or differential diagnostic value. An increase in the lactate concentration among meningitis cases was also demonstrated in multiple studies to be higher in BM than in VM patients (149,(152)(153)(154) and can therefore be regarded as a robust biomarker to differentiate between PVM and PBM. An endocrine analysis for the thyroid function during PVM caused by EVs and mumps showed a noticeable decline in the thyroid hormones concentrations, namely TSH, T3, FT3, and T4, in the sera of infected children (158).…”

Section: Laboratory Abnormalitiesmentioning

confidence: 88%

See 1 more Smart Citation

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

et al. 2022

View full text Add to dashboard Cite

Meningitis is an inflammation of the brain and spinal cord meninges caused by infectious and non-infectious agents. Infectious agents causing meningitis include viruses, bacteria, and fungi. Viral meningitis (VM), also termed aseptic meningitis, is caused by some viruses, such as enteroviruses (EVs), herpesviruses, influenza viruses, and arboviruses. However, EVs represent the primary cause of VM. The clinical symptoms of this neurological disorder may rapidly be observed after the onset of the disease, or take prolonged time to develop. The primary clinical manifestations of VM include common flu-like symptoms of headache, photophobia, fever, nuchal rigidity, myalgia, and fatigue. The severity of these symptoms depends on the patient's age; they are more severe among infants and children. The course of infection of VM varies between asymptomatic, mild, critically ill, and fatal disease. Morbidities and mortalities of VM are dependent on the early recognition and treatment of the disease. There were no significant distinctions in the clinical phenotypes and symptoms between VM and meningitis due to other causative agents. To date, the pathophysiological mechanisms of VM are unclear. In this scientific communication, a descriptive review was performed to give an overview of pediatric viral meningitis (PVM). PVM may occasionally result in severe neurological consequences such as mental retardation and death. Clinical examinations, including Kernig's, Brudzinski's, and nuchal rigidity signs, were attempted to determine the clinical course of PVM with various success rates revealed. Some epidemiological correlates of PVM were adequately reviewed and presented in this report. They were seen depending mainly on the causative virus. The abnormal cytological and biochemical features of PVM were also discussed and showed potentials to distinguish PVM from pediatric bacterial meningitis (PBM). The pathological, developmental, behavioral, and neuropsychological complications of PVM were also presented. All the previously utilized techniques for the etiological diagnosis of PVM which include virology, serology, biochemistry, and radiology, were presented and discussed to determine their efficiencies and limitations. Finally, molecular testing, mainly PCR, was introduced and showed 100% sensitivity rates.

show abstract

Section: -Glucose Concentrationmentioning

confidence: 88%

Section: Laboratory Abnormalitiesmentioning

confidence: 88%

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Blood and interstitial fluid normal glucose values go from 4 mM to 11 mM of glucose [27,28]. However, other biological fluids present glucose maximum values lower than 5 mM, this is the case of pleural, ascites, and spinal liquid besides urine and tears [29][30][31][32][33].…”

Section: Cuomentioning

confidence: 99%

Non-Enzymatic Amperometric Glucose Screen-Printed Sensors Based on Copper and Copper Oxide Particles

et al. 2021

View full text Add to dashboard Cite

Non-enzymatic amperometric glucose sensors have gained much attention in the past decade because of the better chemical and thermal stability and biocompatibility compared to conventional sensors based on the use of biomolecules. This study focuses on a novel copper and copper oxide-based glucose sensor synthesized by an electrodeposition technique through a rigorous protocol which reports an excellent analytical performance due to its structure and its increased active area. In addition, the linear response range, detection limit and sensitivity were 0.5–5.0 mmol L−1, 0.002 mmol L−1, 904 μA mmol−1 L−1 cm−2, respectively. Results show a reliable electrode as it is chemically stable, exhibits rapid and excellent sensitivity, and it is not significantly affected by coexisting species present in the blood samples; furthermore, it reports a maximum relative standard deviation error (RSD) of 6%, and showed long operating life as the electrode was used for thousand measurements of 4.0 mmol L−1 glucose solution during three days.

show abstract

“…Glucose in capillary sample (glucometry) is widely implemented in clinical practice, either in conjunction with glucose in venous sample or, on several occasions, as equivalent thereof when the corresponding measurement has not been performed prior to lumbar puncture [13]. It is usually determined using a glucometer, a medical device based on the dry chemistry method.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic yield of capillary compared to venous glucose in the diagnosis of hypoglycorrhachia in children: A prospective, observational study

Farfán-Albarracín

Ramírez-Sierra

Segura

et al. 2021

Brain and Development

View full text Add to dashboard Cite

Introduction: The ratio of cerebrospinal fluid (CSF) glucose and blood glucose is of major relevance, conducting to the diagnosis of hypoglycorrhachia, which is a sign of neuroinfection, as well as a number of neurological diseases of genetic or neoplastic etiology. Glucose in capillary sample (glucometry) is a low cost, readily available technique, as compared to venous glucose. This study aims to compare glucometry to venous glucose in the diagnosis of hypoglycorrhachia in pediatric population. Methods: Prospective cross-sectional study based on data obtained from lumbar punctures in the period from February 2017 to January 2019 in a specialized pediatric institution in Colombia. Results: 97 patients were analyzed, aged 1 month to 17 years old, mean 7.67 years, 52 (53.61%) were female. 26 (26.8%) were diagnosed with hypoglycorrhachia. Pearson correlation coefficient for absolute venous and capillary glucose was 0.54, and 0.55 for the ratios of CSF glucose/venous glucose and CSF glucose/glucometry, which support a linear correlation between the variables in both, absolute values and ratios. Intraclass correlation coefficient was calculated for both, the venous glucose and glucometry ratios, which was 0.52, revealing a moderate agreement among the tests. Sensitivity and specificity of CSF glucose/glucometry, as compared to gold standard are 73.1% and 60.6% respectively; whereas predictive positive value (PPV) and negative predictive value (NPV), were 40.4% and 86.0%. Conclusion: Glucometry cannot replace the glucose in venous sample in the diagnosis of hypoglycorrhachia in children.

show abstract

Usefulness of blood and cerebrospinal fluid laboratory testing to predict bacterial meningitis in the emergency department

Cited by 13 publications

References 65 publications

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

Etiology, Clinical Phenotypes, Epidemiological Correlates, Laboratory Biomarkers and Diagnostic Challenges of Pediatric Viral Meningitis: Descriptive Review

Non-Enzymatic Amperometric Glucose Screen-Printed Sensors Based on Copper and Copper Oxide Particles

Diagnostic yield of capillary compared to venous glucose in the diagnosis of hypoglycorrhachia in children: A prospective, observational study

Contact Info

Product

Resources

About