Usefulness of coronary angiography in patients with left atrial myxoma

Velasco, Carlos; Suarez, Nathalie P.; Roullard, Christina P.; McCullough, Peter A.; Roberts, William C.

doi:10.1080/08998280.2020.1776024

Cited by 2 publications

(2 citation statements)

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“…Previous studies have reported a wide range, from 0% tp 11% 3–6. Erdil et al found a 36% prevalence rate of CAD2 whereas Fueredi et al 7 and Velasco et al 8 reporting a higher prevalence (66.7% and 82%, respectively). A systematic review and meta-analysis of 109 patients with cardiac myxoma by Silva et al showed a CAD prevalence ranging from 5.3% to 36.3% with an average of 20.7% 9.…”

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confidence: 96%

“…Management in patients with myxoma and concomitant CAD differs. Coronary angiography aids in identifying underlying obstructive coronary artery disease and provides information about tumour vascularity before surgery in patients with myxoma 8. There are no definite guidelines, but patients presenting with acute myocardial infarction with myxoma undergo emergent percutaneous intervention with resection later15 whereas those with stable coronary artery disease can undergo coronary artery bypass grafting and tumour resection simultaneously.…”

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confidence: 99%

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Left atrial myxoma with coronary artery disease

2022

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confidence: 96%

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confidence: 99%

Left atrial myxoma with coronary artery disease

2022

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Cardiac myxomas: a review of current treatment approaches and emerging molecular therapies

Ashinze,

Banerjee,

Egbunu

et al. 2024

Cardiothorac Surg

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Background Cardiac myxomas are the most common primary cardiac tumors, predominantly located in the left atrium. These benign tumors can obstruct blood flow, cause embolization, or produce systemic symptoms like fever. Diagnostic tools such as echocardiography play a critical role in their identification, while surgical resection remains the primary curative treatment. Although recurrence is rare, it occurs more frequently in patients with genetic predispositions, such as the Carney complex. The risk of life-threatening complications such as embolism and sudden death necessitates prompt diagnosis and management. Despite the success of surgical treatment, recent advances have introduced minimally invasive techniques and novel molecular therapies, particularly for recurrent cases. Main body The epidemiology of cardiac myxomas highlights their rarity, with an incidence of 0.5–1 per million individuals annually. They are classified based on location, morphology, and whether they are sporadic or syndromic. Histologically, they originate from multipotent mesenchymal cells and present as gelatinous or solid masses. The genetic implicants, especially in familial cases, involve certain gene mutations, disrupting signaling pathways and leading to tumorigenesis. Diagnosis primarily relies on imaging, with transthoracic echocardiography being the first-line modality. Surgical resection, typically via median sternotomy, remains the gold standard treatment with a low recurrence rate. However, emerging molecular therapies, including gene editing, epigenetic interventions, stem cell therapy, and immunotherapy, offer promising avenues for managing complex or recurrent cases even though they are mostly in conceptual and preclinical phases. These molecular approaches target specific genetic and signaling pathways involved in myxoma formation and recurrence, and though they remain in experimental stages, the advent of gene therapy in oncology makes them the next best choice to watch out for. Conclusions While surgical resection remains curative in most cases, recurrence, particularly in familial syndromes, requires vigilant monitoring and innovative treatments. Emerging molecular therapies show potential in offering personalized treatment options, although they are still inchoate. Further research is needed to improve delivery systems and minimize the challenges associated with these therapies, paving the way for more effective management strategies.

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Usefulness of coronary angiography in patients with left atrial myxoma

Cited by 2 publications

References 11 publications

Left atrial myxoma with coronary artery disease

Left atrial myxoma with coronary artery disease

Cardiac myxomas: a review of current treatment approaches and emerging molecular therapies

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