Usefulness of docetaxel as first‐line chemotherapy for metastatic extramammary Paget's disease

Abstract

In invasive extramammary Paget's disease (EMPD), distant metastases may develop and the condition may become fatal; however, no standardized treatment has been established. Although based on only a few cases, several chemotherapy regimens were reported to be promising. We conducted a multicenter, retrospective study to evaluate the efficacy of docetaxel for metastatic EMPD. We retrospectively collected data on 18 metastatic EMPD patients treated using docetaxel from 1998 to 2012 in 12 institutes in Japan. The following clinical data were collected: tumor response, time to progression, overall survival and adverse effects. Of those, three patients treated combined with S-1, one patient treated with weekly schedule and one patient treated combined with radiotherapy were excluded from the further analysis. All 13 patients received monthly docetaxel as the first-line treatment. The average number of treatment cycles was 9.1. Among the 12 patients with a confirmed response, seven (58%) showed a partial response, three (25%) stable disease and two (17%) progressive disease. The disease control rate (partial response + stable disease) was as high as 83%. The time to progression and median overall survival were 7.1 and 16.6 months, respectively. The 1-year overall survival rate determined by the Kaplan-Meier method was 75.0%. All adverse effects were manageable and no treatment-related deaths were observed. The high disease control rate and overall survival shown by this study suggest that first-line use of docetaxel may be a promising treatment for metastatic EMPD. A prospective clinical trial is required to confirm our results.

Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease

“…Thus, DTX monotherapy is the preferred first‐line treatment based on its lower toxicity and the certain tumor shrinkage effect (RR of 58%). However, its efficacy is not durable, and the reported median PFS and OS were 7.1 and 16.6 months, respectively . Of our five patients receiving PET, four patients showed PR.…”

Weekly docetaxel monotherapy for metastatic extramammary Paget’s disease: Retrospective single‐institute analysis

“…Furthermore, patients undergoing treatment with these combination chemotherapies usually suffer from severe side‐effects and require repeated hospitalization. Thus, DTX monotherapy has been highlighted recently for the first‐line treatment of metastatic EMPD, based on its decent efficacy with few side‐effects . The efficacy of DTX monotherapy has been demonstrated with two different administration schedules in various cancer types: a triweekly regimen involving i.v.…”

“…While a triweekly regimen is officially recommended for DTX, various clinical trials have reported similar pharmacokinetics, similar efficacy and less toxicity with a weekly regimen . To date, two retrospective studies have evaluated the feasibility and efficacy of DTX at 60 mg/m 2 per 3/4 weeks per infusion as first‐line therapy for metastatic EMPD . However, the treatment outcome of its weekly regimen for metastatic EMPD has not yet been explored.…”

Successful TS‐1 monotherapy as the second‐line treatment for advanced extramammary Paget's disease: A report of two cases

“…Because EMPD is a rare cutaneous carcinoma, effective treatments of advanced cases have not been fully established. Yoshino et al . reported that the response rate of DOC was 58% in a 12‐case study.…”