Usefulness of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance cholangiography for detecting mucin retention in bile ducts: a rare intraductal papillary mucinous neoplasm of the bile duct

H, Oki; Hayashida, Yoshiko; Namimoto, Tomohiro; Aoki, Takatoshi; Korogi, Yukunori; Yamashita, Yasuyuki

doi:10.1007/s11604-011-0593-7

Cited by 8 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Typical CT or MRI imaging features were soft vine-like dilatation of the bile ducts inside and outside the liver, and multiple nodules in the bile duct wall. Previous studies have suggested that CT play an important role in identifying benign and malignant diseases of IPMN-B (Oki et al, 2011;Paik et al, 2008). It is reported that ''floating sign'' in the bile duct of MRI imaging is a typical manifestation of IPMN-B (Ying et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological findings and imaging features of intraductal papillary neoplasms in bile ducts

Zhang

Zhong

Kong

et al. 2020

PeerJ

View full text Add to dashboard Cite

Background Intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is considered an uncommon tumor, and there is limited understanding of IPMN-B. This study aimed to investigate the prognosis and influential factors of the IPMN-B from 58 cases. Methods The clinical data of 58 patients with pathologically confirmed IPMN-B admitted to our hospital from January 1, 2012 to August 2017 were collected and analyzed. The patients were followed up by outpatient or telephone until January 1, 2019. SPSS 19.0 software was applied for data analysis. Survival analysis was performed using Kaplan-Meier method and parallel Log-rank test. Prognostic factors were analyzed by univariate analysis and multiple Cox regression model. Results Among of all the patients, 26 cases were benign tumors and 32 cases were malignant tumors. The preoperative tumor markers CA242 and CEA of malignant IPNM-B patients were significantly higher than those in benign tumors (P < 0.05). Survival analysis showed that patients with malignant tumors had a worse prognosis. The median survival time of malignant IPMN-B patients was 40.6 ± 3.0 months, yet median survival time of benign IPMN-B patients was not reached (P = 0.19). The one-year survival rate and three-year survival rate of benign IPMN-B were 84% and 74% respectively. The one-year survival rate and three-year survival rate of malignant IPMN-B were 88% and 64% respectively. Univariate analysis showed that combined lymph node metastasis, surgical method, and differentiation degree could affect patients’ prognosis (P < 0.05). Multivariate analysis showed differentiation degree was an independent risk factor affecting prognosis (OR = 0.06, 95% confidence interval: 0.007∼0.486, P < 0.05). Conclusion The levels of CEA and CA242 were helpful to identify benign and malignant of IPNM-B. Moreover, radical surgical resection could prolong patients’ survival. Finally, differentiation degree was an independent risk factor affecting malignant IPNM-B prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Previous studies have suggested that CT play an important role in identifying benign and malignant diseases of IPMN-B ( Oki et al, 2011 ; Paik et al, 2008 ). It is reported that “floating sign” in the bile duct of MRI imaging is a typical manifestation of IPMN-B ( Ying et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological findings and imaging features of intraductal papillary neoplasms in bile ducts

Zhang

Zhong

Kong

et al. 2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…In a search of the PubMed database, we found 18 articles that addressed cystic IPN-B [5-22]. The 18 articles reported a total of 193 cases of cystic IPN-B in which BDC was confirmed in 120 cases, unclear in 11 cases, and not described in 62 cases.…”

Section: Discussionmentioning

confidence: 99%

Cystic tumor of the liver without ovarian-like stroma or bile duct communication: two case reports and a review of the literature

et al. 2014

View full text Add to dashboard Cite

We report two cases of cystic neoplasm of the liver with mucinous epithelium in which both ovarian-like stroma and bile duct communication were absent. The first case was a 41-year-old woman. She underwent right trisegmentectomy due to a multilocular cystic lesion, 15 cm in diameter, with papillary nodular components in the medial segment and right lobe. Histologically, arborizing papillae were seen in the papillary lesion. The constituent neoplastic cells had sufficient cytoarchitectural atypia to be classified as high-grade dysplasia. The second case was a 60-year-old woman. She underwent left lobectomy due to a unilocular cystic lesion, 17 cm in diameter, in the left lobe. Histologically, the cyst wall was lined by low columnar epithelia with slight cellular atypia. In both cases, neither ovarian-like stroma nor bile duct communications were found throughout the resected specimen. According to the most recent World Health Organization (WHO) classification in 2010, cystic tumors of the liver with mucinous epithelium are classified as mucinous cystic neoplasms when ovarian-like stromata are found, and as intraductal papillary neoplasm of bile duct when bile duct communication exists. Therefore, we diagnosed the cystic tumors as ‘biliary cystadenoma’ according to the past WHO classification scheme from 2000. We believe that the combined absence of both ovarian-like stroma and bile duct communication is possible in mucinous cystic tumors of the liver. Herein, we have described the clinicopathologic features of the two cases and reviewed past cases in the literature.

show abstract

“…The usefulness of gadoxetic acid-enhanced MRI in the diagnosis of IPNB has been reported. During the HBP, IPNB demonstrates a dilated enhanced bile duct with filling defects caused by mucin retention or a solid component of the tumor (Fig 15) (104)(105)(106). Note that when there is a large amount of mucin in a bile duct, it results in marked bile duct dilatation and obvious impaired liver function.…”

Section: Intraductal Papillary Mucinous Neoplasm Of the Bile Ductmentioning

confidence: 99%

Hyperintense Liver Masses at Hepatobiliary Phase Gadoxetic Acid–enhanced MRI: Imaging Appearances and Clinical Importance

et al. 2020

View full text Add to dashboard Cite

Gadoxetic acid, a hepatobiliary-specific contrast medium used for MRI, is becoming increasingly important in the detection and characterization of hepatic mass lesions. This medium is taken up by functioning hepatocytes, and the liver parenchyma is strongly enhanced in the hepatobiliary phase (HBP), during which hepatic mass lesions without functioning hepatocytes commonly show hypointensity. However, some hepatic mass lesions show hyperintensity in the HBP. Focal nodular hyperplasia (FNH) and FNHlike lesions show hyperintensity in the HBP owing to the uptake of gadoxetic acid by hyperplastic normal hepatocytes. The tumor cells of some types of hepatocellular adenoma (eg, β-catenin-activated type, inflammatory type) and hepatocellular carcinoma (eg, green hepatoma) can show uptake of gadoxetic acid. Retention of gadoxetic acid in the extracellular space can cause hyperintensity of fibrotic tumors or hemangiomas during the HBP owing to the extracellular contrast agent characteristics of gadoxetic acid. During the HBP, peritumoral retention is observed in some tumors, such as hepatocellular carcinomas, gastrointestinal stromal tumors, and neuroendocrine tumors. Gadoxetic acid is excreted into the bile; therefore, biliary tract enhancement can be observed in the cystic components of intraductal papillary neoplasms of the bile duct. Intratumoral bile ducts can be observed in malignant lymphomas. Knowledge of these specific mechanisms, which can cause hyperintensity during the HBP depending on the pathologic or molecular background, is important not only for precise imaging-based diagnoses but also for understanding the pathogenesis of hepatic mass lesions. ©

show abstract

Usefulness of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance cholangiography for detecting mucin retention in bile ducts: a rare intraductal papillary mucinous neoplasm of the bile duct

Cited by 8 publications

References 9 publications

Clinicopathological findings and imaging features of intraductal papillary neoplasms in bile ducts

Clinicopathological findings and imaging features of intraductal papillary neoplasms in bile ducts

Cystic tumor of the liver without ovarian-like stroma or bile duct communication: two case reports and a review of the literature

Hyperintense Liver Masses at Hepatobiliary Phase Gadoxetic Acid–enhanced MRI: Imaging Appearances and Clinical Importance

Contact Info

Product

Resources

About