2018
DOI: 10.5021/ad.2018.30.2.158
|View full text |Cite
|
Sign up to set email alerts
|

Usefulness of Inflammatory Markers for the Prediction of Postherpetic Neuralgia in Patients with Acute Herpes Zoster

Abstract: Background: Increasing evidence suggests a pivotal role for neuronal inflammation in response to replicating varicella zoster virus in the development of postherpetic neuralgia (PHN). Objective: In this study, we investigated the value of serum levels of various inflammatory markers in acute herpes zoster (HZ) as predictors for the development of PHN. Methods: A total of 116 patients with acute HZ were enrolled in this study. We measured scores on the pain visual analogue scale (VAS) at baseline and at 1, 3, a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
12
0

Year Published

2019
2019
2022
2022

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 15 publications
(12 citation statements)
references
References 16 publications
0
12
0
Order By: Relevance
“…The underlying mechanisms involved in VZV reactivation and susceptibility among the elderly or immunocompromised populations are currently unclear, although recent studies suggest aging cells as the cause of the inefficient clearance of virus-infected cells (91,92). Few markers that correlate with age-related severity in shingles or poor response to vaccination have also been identified (93)(94)(95). In particular, elderly residents in long-term care experience elevated incidence of shingles and post-herpetic neuralgia due to the high degree of immunosenescence, malnutrition, and existing chronic conditions.…”
Section: Vzvmentioning
confidence: 99%
“…The underlying mechanisms involved in VZV reactivation and susceptibility among the elderly or immunocompromised populations are currently unclear, although recent studies suggest aging cells as the cause of the inefficient clearance of virus-infected cells (91,92). Few markers that correlate with age-related severity in shingles or poor response to vaccination have also been identified (93)(94)(95). In particular, elderly residents in long-term care experience elevated incidence of shingles and post-herpetic neuralgia due to the high degree of immunosenescence, malnutrition, and existing chronic conditions.…”
Section: Vzvmentioning
confidence: 99%
“…PHN negatively impacts patients’ quality of life and causes substantial health‐care burden on individuals and society 1 . Therefore, the development of a model predicting PHN in patients with acute phase HZ is important to establish preventive strategies 2,3 . However, thus far, there have been few reliable PHN‐prediction models that can be easily applied to clinical practice 3 .…”
Section: Group Rash Severitya Superpopulation Fukagawa Municipal Hospital (N = 502) Asahikawa Red Cross Hospital (N = 259) Age Probabilitmentioning
confidence: 99%
“…Therefore, the development of a model predicting PHN in patients with acute phase HZ is important to establish preventive strategies 2,3 . However, thus far, there have been few reliable PHN‐prediction models that can be easily applied to clinical practice 3 . Herein, we present a novel predictive model for PHN using easy‐to‐obtain predictors.…”
Section: Group Rash Severitya Superpopulation Fukagawa Municipal Hospital (N = 502) Asahikawa Red Cross Hospital (N = 259) Age Probabilitmentioning
confidence: 99%
See 1 more Smart Citation
“…HZ manifestations range from a mild itch to agonizing rash and lesions or shingles, all results of the reactivation of dormant or latent varicella zoster virus (VZV) infections (23). Furthermore, PHN can manifest regardless of clinical presentation of zoster (12). PHN generally arises in elderly individuals or in patients with compromised immune systems (8).…”
Section: Introductionmentioning
confidence: 99%