Usefulness of Intraplatelet Melatonin Levels to Predict Angiographic No-Reflow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction

Abreu-González, Pedro; Jiménez-Sosa, Alejandro; Avanzas, Pablo; Bosa‐Ojeda, Francisco; Kaski, Juan Carlos

doi:10.1016/j.amjcard.2010.07.030

Cited by 13 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with angiographic no‐reflow had lower intra‐platelet melatonin levels compared to patients without no‐reflow. Additionally, regression analysis showed that intra‐platelet melatonin levels were the only predictor of angiographic no‐reflow following MI …”

Section: Melatonin and Cardiovascular Diseasementioning

confidence: 99%

“…Additionally, regression analysis showed that intra-platelet melatonin levels were the only predictor of angiographic no-reflow following MI. 31 Overall, though some of the aforementioned studies may be considered to have a limited number of patients, there is clear and strong evidence of reduced melatonin in various cardiovascular diseases. However, further research including larger scale studies with larger clinical populations are needed to help identify whether reduced melatonin levels are the cause or consequence of such conditions.…”

Section: Myocardial Infarcts (Mi)mentioning

confidence: 99%

See 1 more Smart Citation

Role of melatonin in blood pressure regulation: An adjunct anti‐hypertensive agent

Baker

Kimpinski

2018

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Cardiovascular diseases account for approximately one-third of all deaths each year. Of this, hypertension accounts for approximately 9.4 million deaths. Melatonin, the primary circadian hormone, has been substantiated as an effective and safe adjunct anti-hypertensive agent. In support of this, melatonin receptors have been identified within the central and peripheral nervous system, as well as the cardiovascular system, including various vascular tissues. Therefore, it is not surprising that recent research has emerged highlighting a key role of melatonin in autonomic regulation of blood pressure. In animals, pinealectomies elicit peripheral vasoconstriction and hypertension. In studies involving humans, both healthy controls and patient populations of essential and nocturnal hypertension, melatonin administration demonstrates significant hypotensive effects that yield clinically significant results. However, the precise mechanism by which melatonin elicits its hypotensive effects in humans require further investigation. This review focuses on melatonin, its role within the cardiovascular system and the emerging implications for its use as an anti-hypertensive agent. Additionally, this review will discuss the current thinking on potential mechanisms behind the hypotensive effects of melatonin including: endothelium-dependent vasodilation, anti-oxidant defence mechanisms and sympatho-vagal autonomic regulation.

show abstract

Section: Melatonin and Cardiovascular Diseasementioning

confidence: 99%

Section: Myocardial Infarcts (Mi)mentioning

confidence: 99%

Role of melatonin in blood pressure regulation: An adjunct anti‐hypertensive agent

Baker

Kimpinski

2018

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…Melatonin reduces farc size/risk and reperfusion arrhythmia against I/R injury. Ischemia is associated with reactive oxygen species/nitric oxide synthase formation from residual molecular oxygen, thus ability of melatonin may be involved in heart protection efficacy by removal of free radical and of induction of the expression of antioxidant enzyme ( Reiter & Tan, 2003b ; Dominguez-Rodriguez et al, 2010a ).…”

Section: Activities Of Melatoninmentioning

confidence: 99%

Potency of Melatonin in Living Beings

Choi¹

2013

Development &Amp; Reproduciton

View full text Add to dashboard Cite

Living beings are surrounded by various changes exhibiting periodical rhythms in environment. The environmental changes are imprinted in organisms in various pattern. The phenomena are believed to match the external signal with organisms in order to increase their survival rate. The signals are categorized into circadian, seasonal, and annual cycles. Among the cycles, the circadian rhythm is regarded as the most important factor because its periodicity is in harmony with the levels of melatonin secreted from pineal gland. Melatonin is produced by the absence of light and its presence displays darkness. Melatonin plays various roles in creatures. Therefore, this review is to introduce the diverse potential ability of melatonin in manifold aspects in living organism.

show abstract

“…26 In another related study of 180 consecutive patients with a first ST-segment elevation myocardial infarction who underwent percutaneous coronary intervention within 6 hours from onset of symptoms, patients with angiographic no-reflow had lower intraplatelet melatonin levels compared to patients without noreflow. 28 Intraplatelet melatonin levels were the only significant predictor of angiographic no-reflow after adjusting for potential confounders. Low urinary aMT6s excretion was reported in CHF, a decrease that was observed regardless of b-adrenergic blocker.…”

Section: Melatonin Levels In Cvdsmentioning

confidence: 90%

Melatonin and Human Cardiovascular Disease

Pandi-Perumal

BaHammam

Ojike

et al. 2016

J Cardiovasc Pharmacol Ther

View full text Add to dashboard Cite

The possible therapeutic role of melatonin in the pathophysiology of coronary artery disorder (CAD) is increasingly being recognized. In humans, exogenous melatonin has been shown to decrease nocturnal hypertension, improve systolic and diastolic blood pressure, reduce the pulsatility index in the internal carotid artery, decrease platelet aggregation, and reduce serum catecholamine levels. Low circulating levels of melatonin are reported in individuals with CAD, arterial hypertension, and congestive heart failure. This review assesses current literature on the cardiovascular effects of melatonin in humans. It can be concluded that melatonin deserves to be considered in clinical trials evaluating novel therapeutic interventions for cardiovascular disorders.

show abstract

Usefulness of Intraplatelet Melatonin Levels to Predict Angiographic No-Reflow After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction

Cited by 13 publications

References 27 publications

Role of melatonin in blood pressure regulation: An adjunct anti‐hypertensive agent

Role of melatonin in blood pressure regulation: An adjunct anti‐hypertensive agent

Potency of Melatonin in Living Beings

Melatonin and Human Cardiovascular Disease

Contact Info

Product

Resources

About