Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients

Abstract

Early detection of atrial fibrillation patients at high risk for stroke is important. There are some studies which indicate that mean platelet volume (MPV) determines the prognosis and risk in patients with a stroke. In this study, our aim was to investigate the association between the MPV measured in stroke patients with atrial fibrillation. Consecutive patients referred to our center between January 2010 and April 2012 were included in this study. The patients with atrial fibrillation were classified into two groups according to presence or absence of a history of stroke by combining data from the medical histories after a thorough review of the medical records. MPV determination was made within 24 h following the onset of stroke. We studied 63 consecutive stroke patients with atrial fibrillation and 77 atrial fibrillation patients without stroke history. In receiver-operating characteristic (ROC) curve analysis, the value for MPV levels to detect stroke with a sensitivity of 63.5% and specificity of 64.4% was 9.4 fl. High MPV (>9.4 fl) was significantly associated with the occurrence of stroke [odds ratio (OR) 4.021, 95% confidence interval (CI) 1709-9464, P < 0.001]. Our study supports the hypothesis that a high MPV is associated with an increased risk of stroke in atrial fibrillation patients.

Thrombin generation - a potentially useful biomarker of thrombotic risk in Philadelphia-negative myeloproliferative neoplasms

“…The association of high level of thrombin generation parameters with a high mean platelet volume, which is a recognized independent risk factor for stroke in patients with atrial fibrillation 23 , or with the presence of microparticles which simultaneously express CD62E and CD41 in Ph-negative MPN patients could be other aims for future thrombotic risk studies.…”

Mean platelet volume as diagnostic and therapeutic marker of risk and prognosis of heart disease

“…21,22 There is a positive association between MPV and the severity of acute ischemic stroke 23 and in predicting the risk of ischemic stroke in patients with atrial fibrillation. [24][25][26] Butterworth and Bath 27 reported that platelet volume is increased in patients with acute ischemic stroke. O'malley et al 28 reported high values of MPV in all subtypes of ischemic stroke.…”

Mean platelet volume is related with ischemic stroke in patients with sinus rhythm

“…The relationship between increased platelet activity and atherosclerotic disease, including stroke, has been well documented [6][7][8]. It has been shown that high MPV is associated with an increased risk of stroke [9] and is an independent risk factor for stroke [10] in patients with atrial fibrillation. Furthermore, in a previous study Kim et al [11] showed that left atrium diameter is an independent predictor of stroke in patients without atrial fibrillation.…”