Usefulness of Neutrophil-to-Lymphocyte Ratio to Predict In-hospital Outcomes in Infective Endocarditis

Turak, Osman; Özcan, Fırat; İşleyen, Ahmet; Başar, Fatma; Gül, Murat; Yılmaz, Samet; Sökmen, Erdoğan; Yüzgeçer, Hüseyin; Lafçı, Gökhan; Topaloğlu, Serkan; Aydoğdu, Sinan

doi:10.1016/j.cjca.2013.05.005

Cited by 61 publications

(44 citation statements)

References 25 publications

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“…25,26 It was also reported to be correlated to serious clinical conditions in infectious diseases. 27,28 In CKD patients, NLR was also associated with disease deterioration and complications occurred. It overwhelms traditional inflammation markers including IL-6 and TNF-a in patients who just started their renal replacement therapy.…”

Section: Discussionmentioning

confidence: 99%

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Fei

Chen

Cao

et al. 2017

Hemodialysis International

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Section: Discussionmentioning

confidence: 99%

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Fei

Chen

Cao

et al. 2017

Hemodialysis International

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“…In recent years, with the growing understanding of the role of various inflammatory markers in IE, studies have been focused on other inflammatory markers. Turak et al [9] retrospectively analyzed 121 patients with definite IE and hypothesized that increased NLR level on admission would predict unfavorable in-hospital outcomes. They showed that NLR on admission is an independent predictor of inhospital mortality in IE cases [9].…”

Section: Discussionmentioning

confidence: 99%

Association between hematologic parameters and in‐hospital mortality in patients with infective endocarditis

Zencir

Akpek

Şenol

et al. 2015

The Kaohsiung J of Med Scie

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Early and accurate risk prediction is an important clinical demand in patients with infective endocarditis (IE). The platelet-to-lymphocyte ratio (PLR) is an independent predictor of worse prognosis in various cardiovascular diseases. The aim of this study was to determine the value of PLR in the prediction of in-hospital mortality among IE patients. We retrospectively analyzed the clinical, laboratory, and echocardiographic data of 59 adult patients with definite IE and in 40 adult controls. In-hospital mortality occurred in 16 (27%) patients. Vegetation size, levels of high-sensitive C-reactive protein and procalcitonin, neutrophil-to-lymphocyte ratio, and PLR were significantly higher in the in-hospital-mortality-positive group than in the in-hospital-mortality-negative group (p = 0.004, p = 0.009, p = 0.030, p = 0.001, and p = 0.008, respectively). Lymphocyte count was, however, significantly lower in the in-hospital-mortality-positive group (p = 0.004). In the receiver-operating characteristic analysis, PLRs over 191.01 predicted in-hospital mortality with 56.3% sensitivity and 81.4% specificity [area under the curve 0.725, 95% confidence interval (CI) 0.594-0.833; p = 0.0027]. In the multivariate analysis, PLR was found to be an independent predictor of in-hospital mortality in patients with IE (odds ratio 1.022, 95% CI 1.003-1.042; p = 0.021). In conclusion, higher PLR may predict in-hospital mortality in patients with IE.

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“…Repeated NLR measurements over time are required to provide evidence for a possible role of NLR in the pathogenesis of delirium. Third, it might be speculated that other comorbidities, such as cardiovascular diseases,9–11 diabetes,41 malignancies,12 infection,15 and inflammation,14 might have influenced the mean levels of NLR; however, even after adjustment for the CCI and other inflammatory markers, estimates remained statistically significant. Fourth, only in a relatively small number of patients neutrophil and lymphocyte counts were measured on admission and this might have introduced some selection bias.…”

Section: Limitations and Strengthsmentioning

confidence: 99%

Increased neutrophil–lymphocyte ratio in delirium: a pilot study

Egberts¹,

Mattace-Raso²

2017

CIA

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AimDelirium is a common and severe complication among older hospitalized patients. The pathophysiology is poorly understood, but it has been suggested that inflammation and oxidative stress may play a role. The aim of this pilot study was to investigate levels of the neutrophil–lymphocyte ratio (NLR) – a marker of systemic inflammation and oxidative stress – in patients with and without delirium.MethodsThis pilot study was performed within a retrospective chart review study that included acutely ill patients, 65 years and older, who were admitted to the ward of geriatrics of the Erasmus University Medical Center. All patients in whom the differential white blood cell (WBC) counts as well as the C-reactive protein (CRP) level were determined within 24 h after admission were included in the present study. Differences in NLR between patients with and without delirium were investigated using univariate analysis of variance, with adjustments for age, sex, comorbidities, CRP level, and total WBC count.ResultsEighty-six patients were included. Thirteen patients were diagnosed with delirium. In adjusted models, higher mean NLR values were found in patients with, than in those without, delirium (9.10 vs 5.18, P=0.003).ConclusionIn this pilot study, we found increased NLR levels in patients with delirium. This finding might suggest that an inadequate response of the immune system and oxidative stress may play a role in the pathogenesis of delirium. Further studies are needed to confirm the association between NLR and delirium.

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Usefulness of Neutrophil-to-Lymphocyte Ratio to Predict In-hospital Outcomes in Infective Endocarditis

Cited by 61 publications

References 25 publications

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Association between hematologic parameters and in‐hospital mortality in patients with infective endocarditis

Increased neutrophil–lymphocyte ratio in delirium: a pilot study

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Usefulness of Neutrophil-to-Lymphocyte Ratio to Predict In-hospital Outcomes in Infective Endocarditis

Cited by 61 publications

References 25 publications

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Association between hematologic parameters and in‐hospital mortality in patients with infective endocarditis

Increased neutrophil&ndash;lymphocyte ratio in delirium: a pilot study

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Increased neutrophil–lymphocyte ratio in delirium: a pilot study