Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China

Li, Tiaoying; Itō, Akira; Chen, Xingwang; Long, Changping; Okamoto, Masanori; Raoul, Francis; Giraudoux, Patrick; Yanagida, Tetsuya; Nakao, Minoru; Sako, Yasuhito; Xiao, Ning; Craig, Philip S.

doi:10.1016/j.actatropica.2012.08.002

Cited by 56 publications

(51 citation statements)

References 19 publications

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“…Thus far, no NCC related clinical manifestations have been reported in response to niclosamide administration, including in 3 patients with confirmed dual infections [40]. Chinese traditional medicine (pumpkin seeds plus areca nut extract) has also been used to expel tapeworms without the risk of causing seizures [26,54,60].…”

Section: Discussionmentioning

confidence: 99%

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Neurocysticercosis Diagnosed in a Patient with Taenia saginata Taeniasis after Administration of Praziquantel: A Case Study and Review of the Literature

Toni¹,

'²,

Sudewi³

et al. 2016

Primary Health Care

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IntroductionTaeniasis/cysticercosis, caused by the pork tapeworm, Taenia solium, is a parasitic zoonosis found primarily in countries where pigs are raised and meat inspection is lacking [1,2]. The potential for a tapeworm carrier to infect another individual (or themselves via autoinfection), resulting in cysticercosis or neurocysticercosis (NCC), is a risk not only in endemic areas, but also in areas with immigrants from endemic countries [1,[3][4][5]]. An example of such an outbreak occurred in an Orthodox Jewish community in New York City when family members were infected by a domestic employee from a T. solium endemic country [6]. Such NCC outbreaks have occurred in other developed countries, including countries in the Middle East where people do not consume pork [4,5,[7][8][9][10][11][12][13].In Asia, there are three Taenia tapeworms that infect humans; T. solium, Taenia saginata and Taenia asiatica [4,5,[14][15][16][17][18][19][20][21][22][23][24]. Although adult T. solium worms with scoleces are easily differentiated morphologically from other taeniids, it is almost impossible to differentiate adult T. asiatica and T. saginata [5,22,25,26]. Therefore, molecular differentiation is often required to correctly identify the infecting species [27]. Recent studies have also reported hybrids of T. saginata and T. asiatica in Thailand and China [5,25,[28][29][30][31][32]. This makes mitochondrial and nuclear gene analyses even more important for the differentiation of T. saginata, T. asiatica, and hybrids of these two species [30][31][32].In Indonesia, T. solium, T. saginata and T. asiatica are distributed according to livestock rearing and local food consumption practices [33][34][35][36][37][38][39][40]. Both T. saginata and T. solium have been confirmed from the island of Bali, where the local inhabitants are known to eat dishes that contain undercooked beef and pork, such as the traditional dish Lawar. NCC was considered endemic on Bali more than 20 years ago [41,42]. However, education programs aimed at keeping pigs indoors to prevent access to human faeces and the introduction of improved sanitation systems and practices have substantially reduced the prevalence of NCC during the past 2 decades [35,37,43]. Nevertheless, there are still sporadic NCC cases identified on Bali [40,[42][43][44][45]. Case ReportFieldwork conducted on Bali from 2002-2007 resulted in the identification of 69 taeniasis carriers who were treated with a single dose of praziquantel (PZQ) at 15 mg/kg body weight (Table 1). All worms were confirmed to be T. saginata by multiplex PCR [36]. In August 2007, a 47-year-old male taeniasis carrier from the Gianyar district suffered a single tonic-clonic seizure within a few hours of PZQ administration. The patient was subsequently admitted to the Sanglah Hospital in Denpasar. A computed tomography (CT) scan revealed one viable cystic lesion and one calcified lesion in the right frontal lobe of the brain. At this time, serology (ELISA) was also carried out using partially purified antigens by c...

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Section: Discussionmentioning

confidence: 99%

“…Although adult T. solium worms with scoleces are easily differentiated morphologically from other taeniids, it is almost impossible to differentiate adult T. asiatica and T. saginata [5,22,25,26]. Therefore, molecular differentiation is often required to correctly identify the infecting species [27].…”

Section: Introductionmentioning

confidence: 99%

Neurocysticercosis Diagnosed in a Patient with Taenia saginata Taeniasis after Administration of Praziquantel: A Case Study and Review of the Literature

Toni¹,

'²,

Sudewi³

et al. 2016

Primary Health Care

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“…Intestinal tapeworms were familiar among physicians of different ancient civilizations, who treated them with pumpkin seeds ( Cucurbita pepo ), a herbal medicine that it is still used nowadays (Li et al 2012 ). Also, the occurrence of swine cysticercosis (measly pork) was a common knowledge among the ancient Greeks.…”

Section: Ancient Knowledgementioning

confidence: 99%

History of Taeniasis and Cysticercosis

Brutto

Garcı́a

2013

Cysticercosis of the Human Nervous System

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“…Although praziquantel and niclosamide are used extensively for taeniasis treatments in endemic areas, the former is highly destructive to the worm, whereas the latter cases have much less destruction however is not highly effective for expelling an adult worm. 18,19 Because niclosamide cannot be commercially available in Japan, a Gastrographin injection method is the first choice for treatment of taeniasis solium and several Japanese physicians have reported successful complete ejection of Diphyllobothrium nihonkaiense, Taenia saginata, and T. solium without destruction with such a technique. [20][21][22] In this patient, we administered albendazole at a dose of 15 mg/kg/day for 28 days, oral prednisone (1 mg/kg/day) for 2 weeks, and valproate sodium.…”

Section: Discussionmentioning

confidence: 99%

Rare Case of Disseminated Cysticercosis and Taeniasis in a Japanese Traveler after Returning from India

Kobayashi

Nakamura‐Uchiyama²,

Nishiguchi³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. We report disseminated cysticercosis concurrent with taeniasis in a 31-year-old male Japanese, who had visited India three times and stayed for 1 month each time during the previous 1 year. The patient presented increasing numbers of subcutaneous nodules and expelled proglottids, although numerous cysts were also found in the brain in imaging findings, though no neurological symptoms were observed. Histopathological and serological findings strongly indicated cysticercosis. We found taeniid eggs in his stool by microscopic examination and revealed them as the Indian haplotype of Taenia solium by mitochondrial DNA analysis. We concluded that disseminated cysticercosis was caused by the secondary autoinfection with eggs released from the tapeworm carrier himself. After confirming the absence of adult worms in the intestine by copro-polymerase chain reaction, the patient was successfully treated with albendazole at a dose of 15 mg/kg/day for 28 days. Subcutaneous and intracranial lesions had completely disappeared by the end of the treatment period.

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Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China

Cited by 56 publications

References 19 publications

Neurocysticercosis Diagnosed in a Patient with Taenia saginata Taeniasis after Administration of Praziquantel: A Case Study and Review of the Literature

Neurocysticercosis Diagnosed in a Patient with Taenia saginata Taeniasis after Administration of Praziquantel: A Case Study and Review of the Literature

History of Taeniasis and Cysticercosis

Rare Case of Disseminated Cysticercosis and Taeniasis in a Japanese Traveler after Returning from India

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