Usefulness of reversed-phase HPLC enriched with room temperature imidazolium based ionic liquids for lipophilicity determination of the newly synthesized analgesic active urea derivatives

Synthesis of new derivatives of 9-(2-pyridyl)-3-aryl(arylalkyl)- -2,4,5(9H)trioxo-7,8-dihydroimidazo[1,2-a][1,3,5]triazepine

“…General procedure for the synthesis of 9-(2-pyridyl)- [6,12] with diethyl oxalic acid ester. The reaction was conducted in the boiling temperature of the solvent.…”

“…In the search for new structures with potential pharmacological activity, a set of novel imidazo [1,2-a] [1,3,5]triazepines has been obtained. Some known derivatives of imidazotriazepine show activity as muscle relaxants [1], the others have antifungal [8], anti-diabetic [3,9,10], antimicrobial [2,4,5], antiviral [7,14], anticancer [7] and analgesic [6] properties. This heterocyclic system has been obtained by us in a two-step reaction.…”

Chiral separation and determination of amino acids in real samples by LE-MEKC using Cu(II)-l-proline as chiral selector

“…Meanwhile, the analysis of amino acids is very popular in recent decades, and a large number of analytical achievements are reported. For example, analysis of amino acids has been extensively investigated by high-performance liquid chromatography [5,6] and gas chromatography using chiral stationary phases or chiral mobile phase additives [7,8]. The traditional analysis of chiral drugs often meets some problems in the separation process such as high cost and use of a large quantity of harmful organic solvents [9,10].…”

Revisiting thin-layer chromatography as a lipophilicity determination tool. Part IV — A closer look on extrapolation and averaging

“…There are almost all watermiscible solvents used as modifiers and many computational approachesfrom simple linear extrapolation to advanced chemometric methods. Newer ideas are also proposed -for example, use of ionic liquids [1] or micellar mobile phases [2] with high-performance liquid chromatography (HPLC), which was not done in thin-layer chromatography (TLC). There have been dozens of papers published since the first part of our study.…”