Usefulness of serum CA125 measurement for monitoring pericardial effusion.

Seo, Toshihiko; Ikeda, Yoshihiro; Onaka, Haruhiko; Hayashi, Takahiro; Kawaguchi, Keizo; Kotake, Chikao; Toda, Tsunenori; Kobayashi, Katsuya

doi:10.1253/jcj.57.489

Cited by 53 publications

(43 citation statements)

References 9 publications

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“…In several reports high CA125 was associated with serosal effusions, suggesting that the presence of serosal fluids may stimulate its release [8][9][10].…”

Section: Discussionmentioning

confidence: 96%

“…Numerous studies showed increased CA125 levels in CHF patients and a relationship between these values and HF severity [5][6][7][8][9][10][11][12][13][14][15]. In the present study, we investigated the prognostic value of CA125 levels in an AHF population.…”

Section: Discussionmentioning

confidence: 99%

“…Carbohydrate antigen 125 (CA125) is a tumour marker classically associated with ovarian cancer [4]; recently several studies reported increased serum CA125 levels in HF patients [5][6][7][8][9][10][11][12][13][14][15]. However, it is still a matter of debate if CA125 is a potential prognostic marker for AHF and also if it is useful for evaluating and managing pre-transplant patients.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of CA125 in advanced heart failure patients

Monteiro

Franco

Costa

et al. 2010

International Journal of Cardiology

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Introduction: Serum levels of CA125 are often high in advanced heart failure (AHF) patients. Aim: To determine the predictive value of CA125 in forecasting the occurrence of death or cardiac transplantation in an AHF population. Methods: 88 AHF patients referred for heart transplantation were divided into 2 groups based on CA125 levels: normal (CA125 b 38 U/mL) and elevated (≥ 38 U/mL). Events (death or heart transplant) were monitored over a period of 13 ± 7 months after CA125 determination. Results: Patients with elevated CA125 (n = 65) had significantly lower blood pressure, body mass index, serum sodium and peak exercise oxygen consumption, while B-type natriuretic peptide levels were significantly higher. The combined primary endpoint (death or heart transplant) rate was 39.4% and 62.3% in normal and elevated CA125 groups, respectively (p = 0.029). Multivariate regression analysis showed that CA125 and sodium levels were the only independent predictors of the combined endpoint. Conclusion: In AHF patients, plasma CA125 was an effective prognostic marker. Its determination may contribute to better risk stratification in this population.

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“…In several reports high CA125 was associated with serosal effusions, suggesting that the presence of serosal fluids may stimulate its release [8][9][10].…”

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic value of CA125 in advanced heart failure patients

Monteiro

Franco

Costa

et al. 2010

International Journal of Cardiology

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“…7 However, increased serum levels of CA 125 have been frequently observed in patients affected by malignancies other than ovarian cancer as well as those affected by different nonmalignant diseases such as digestive tract cancer, 8 acute leukemia, 9 non-Hodgkin lymphoma, 10 endometriosis, 11 ascites, 12 pelvic inflammatory diseases, 13 tuberculous peritonitis, 14 and pericarditis. 15 Recently, CA 125 levels have been shown to be increased in patients with HF.…”

Section: Introductionmentioning

confidence: 99%

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

et al. 2013

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Purpose: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). Methods: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. Results: The mean CA 125 level in patients, 38.78 AE 35.48 U/ mL, was significantly higher than that found in healthy controls (9.20 AE 4.55 U/mL; p ¼ 0.003). Patients with elevated CA 125 levels (n ¼ 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r ¼ 0.596, p50.05) and C-reactive protein (CRP) levels (r ¼ 0.439, p50.05), as well as LVEDd (r ¼ 0.599, p50.001), LVESd (r ¼ 0.750, p50.001) and LV mass index (r ¼ 0.378, p50.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r ¼ À0.513, p50.05) and hemoglobin (r ¼ À0.475, p50.05) as well as the EF (r ¼ À0.878, p50.0001). A depressed EF ( ¼ À1.121, p50.0001) and increased CRP levels ( ¼ 0.247, p ¼ 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. Conclusions: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.

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“…It is particularly difficult to diagnose malignant disease. With regard to pathogenesis, some examples of hypothyroidism with elevated tumor markers, including serum CA125 and others, have been reported [1][2][3][4][5]. These associations are also controversial.…”

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confidence: 99%

Severe Ascites with Hypothyroidism and Elevated CA125 Concentration: A Case Report

et al. 2007

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Abstract. Ascites caused by hypothyroidism is rare and the pathogenesis is unclear. Several reports have presented cases of progressive ascites with hypothyroidism and elevated tumor markers. We report a 31-year-old female case with massive ascites and elevated serum CA 125 concentrations. The patient had no typical feature of hypothyroidism except an accumulation of ascitic fluid which showed elevated total protein concentration and a high serum-ascites albumin gradient (SAAG). There was no finding of malignancy. Following thyroid hormone replacement, the ascites was completely resolved accompanied by reduced concentrations of serum CA125. In general, primary hypothyroidism with ascites presents with coexisting massive pericardial or pleural effusion. The massive ascites and increased serum CA125 concentrations may have led us to make the incorrect diagnosis of ovarian malignancy. The evaluation of thyroid function is useful to determine the pathology of high-protein ascites or elevated tumor markers, and ascites may be treatable by thyroid replacement therapy.

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Usefulness of serum CA125 measurement for monitoring pericardial effusion.

Cited by 53 publications

References 9 publications

Prognostic value of CA125 in advanced heart failure patients

Prognostic value of CA125 in advanced heart failure patients

CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis

Severe Ascites with Hypothyroidism and Elevated CA125 Concentration: A Case Report

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