Usefulness of Serum Procalcitonin as a Markerfor Coexisting Infection in Patients With Acute Myocardial Infarction

Vitkon-Barkay, Itzhak; Lazarovitch, Tsilia; Marchaim, Dror; Temkin, Elizabeth; Martin, Emily T.; Segaloff, Hannah E; Litovchik, Ilya; Rum, Victoria; Richter, Chana; Tzuman, Oran; Vered, Zvi; Minha, Sa’ar

doi:10.1016/j.amjcard.2018.05.004

Cited by 4 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study expands on previous findings by focusing on a larger population (n = 569) and including all types of ACS. The rate of infection we found (eight percent) was lower than that of Vitkon-Barkay et al [15]. This might be related to the slight difference in the definition used to detect infection [15].…”

Section: Discussioncontrasting

confidence: 80%

“…The rate of infection we found (eight percent) was lower than that of Vitkon-Barkay et al [15]. This might be related to the slight difference in the definition used to detect infection [15]. In our study, the inclusion of patients with a fever and positive cultural tests together, combined with clinical and laboratory data and the infectious specialist evaluation, might have made the inclusion of patients with an infectious event more restrictive.…”

Section: Discussioncontrasting

confidence: 70%

“…A previous study on 230 MI patients showed that PCT was useful for ruling out infection in patients hospitalized with MI [15]. The authors suggested that PCT could serve as a valid auxiliary test useful for ruling out infections in patients with MI with a negative predictive value of nearly 99% [15]. Our study expands on previous findings by focusing on a larger population (n = 569) and including all types of ACS.…”

Section: Discussionsupporting

confidence: 70%

“…Our data confirms these finding, showing the usefulness of performing early PCT diagnostics on ACS patients to detect the development of bacterial infections in patients still without signs of infection. A previous study on 230 MI patients showed that PCT was useful for ruling out infection in patients hospitalized with MI [15]. The authors suggested that PCT could serve as a valid auxiliary test useful for ruling out infections in patients with MI with a negative predictive value of nearly 99% [15].…”

Section: Discussionmentioning

confidence: 96%

“…Previous data about the incidence of bacterial infection during ACS are controversial with rates ranging between 4% and 15% [15,16]. We set an occurrence rate of bacterial infection around 6% and supposed that the occurrence of bacterial infection would be at least 3 times higher in ACS patients with baseline (before the clinical signs of infection) procalcitonin above the cut-off for normal levels as compared to those with procalcitonin in the range of normality.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Procalcitonin Predicts Bacterial Infection, but Not Long-Term Occurrence of Adverse Events in Patients with Acute Coronary Syndrome

Pavasini

Fabbri

Marchini

et al. 2022

JCM

View full text Add to dashboard Cite

This study compiles data to determine if procalcitonin (PCT) values may predict both the risk of bacterial infection and potentially negative long-term outcomes in patients with acute coronary syndromes (ACS). All patients with a diagnosis of ACS that had PCT levels assessed during the first 24 h of hospitalization were enrolled in this study. The primary outcome was to detect the presence of bacterial infection defined as the occurrence of fever and at least one positive blood or urinary culture with clinical signs of infection. The secondary outcome was to monitor the occurrence after 1 year of the composite outcome of all-cause mortality, stroke and myocardial infarction. Overall, 569 patients were enrolled (mean age 69.37 ± 14 years, 30% females). Of these, 44 (8%) met the criteria for bacterial infection. After multivariate analysis, PCT and SBP were found to be independent predictors of bacterial infections (OR for PCT above the cut-off 2.67, 95% CI 1.09–6.53, p = 0.032 and OR for SBP 0.98, 95% CI 0.97–0.99, p = 0.043). After 1 year, the composite outcome of all-cause death, MI and stroke occurred in 104 patients (18%). PCT was not found to be an independent predictor of these outcomes. In conclusion, when assessing ACS, we found that testing for PCT levels during hospital admissions procedures was a good predictor of bacterial infections but not of all-cause mortality, stroke, or myocardial infarction. Clinicaltrial.org identifier: NCT02438085.

show abstract

Section: Discussioncontrasting

confidence: 80%

Section: Discussioncontrasting

confidence: 70%

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Procalcitonin Predicts Bacterial Infection, but Not Long-Term Occurrence of Adverse Events in Patients with Acute Coronary Syndrome

Pavasini

Fabbri

Marchini

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

Association of Myocardial Injury With Serum Procalcitonin Levels in Patients With ST-Elevation Myocardial Infarction

et al. 2020

View full text Add to dashboard Cite

IMPORTANCE Myocardial tissue injury due to acute ST-elevation myocardial infarction (STEMI) initiates an inflammatory response that leads to a release of systemic inflammatory biomarkers, including C-reactive protein (CRP) and white blood cells, consequently reducing the usefulness of these routine biomarkers for identifying concomitant infections. The clinical role of procalcitonin (PCT), a promising marker of bacterial infection, to detect concomitant infection in acute STEMI is unknown, mainly because it is unclear whether myocardial injury per se induces systemic PCT release. OBJECTIVE To investigate the release of serum PCT in the acute setting of STEMI (24 and 48 hours after primary percutaneous coronary intervention) and to elucidate any associations with myocardial injury markers through a comprehensive assessment by cardiac magnetic resonance (CMR) imaging. DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study conducted between 2016 and 2018 included 141 consecutive patients with STEMI treated with primary percutaneous coronary intervention. Concentrations of PCT, high-sensitivity CRP (hs-CRP), and high-sensitivity cardiac troponin T (hs-cTnT) and white blood cell counts were measured serially 24 and 48 hours after infarct. EXPOSURES Acute STEMI and primary percutaneous coronary intervention. MAIN OUTCOMES AND MEASURES The association of PCT and typical inflammatory marker levels with CMR-determined myocardial damage was assessed. Infarct size, extent of microvascular obstruction, and occurrence of intramyocardial hemorrhage as determined by CMR within the first week following STEMI were also evaluated. RESULTS In total, 141 patients with STEMI (117 men [83%]) having a median age of 56 years (interquartile range, 50-66 years) were included. The median PCT concentration was 0.07 μg/L

show abstract

Differential gene expression patterns in ST-elevation Myocardial Infarction and Non-ST-elevation Myocardial Infarction

Elahimanesh,

Shokri,

Mahdinia

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The ST-elevation Myocardial Infarction (STEMI) and Non-ST-elevation Myocardial Infarction (NSTEMI) might occur because of coronary artery stenosis. The gene biomarkers apply to the clinical diagnosis and therapeutic decisions in Myocardial Infarction. The aim of this study was to introduce, enrich and estimate timely the blood gene profiles based on the high-throughput data for the molecular distinction of STEMI and NSTEMI. The text mining data (50 genes) annotated with DisGeNET data (144 genes) were merged with the GEO gene expression data (5 datasets) using R software. Then, the STEMI and NSTEMI networks were primarily created using the STRING server, and improved using the Cytoscape software. The high-score genes were enriched using the KEGG signaling pathways and Gene Ontology (GO). Furthermore, the genes were categorized to determine the NSTEMI and STEMI gene profiles. The time cut-off points were identified statistically by monitoring the gene profiles up to 30 days after Myocardial Infarction (MI). The gene heatmaps were clearly created for the STEMI (high-fold genes 69, low-fold genes 45) and NSTEMI (high-fold genes 68, low-fold genes 36). The STEMI and NSTEMI networks suggested the high-score gene profiles. Furthermore, the gene enrichment suggested the different biological conditions for STEMI and NSTEMI. The time cut-off points for the NSTEMI (4 genes) and STEMI (13 genes) gene profiles were established up to three days after Myocardial Infarction. The study showed the different pathophysiologic conditions for STEMI and NSTEMI. Furthermore, the high-score gene profiles are suggested to measure up to 3 days after MI to distinguish the STEMI and NSTEMI.

show abstract

Usefulness of Serum Procalcitonin as a Markerfor Coexisting Infection in Patients With Acute Myocardial Infarction

Cited by 4 publications

References 28 publications

Procalcitonin Predicts Bacterial Infection, but Not Long-Term Occurrence of Adverse Events in Patients with Acute Coronary Syndrome

Procalcitonin Predicts Bacterial Infection, but Not Long-Term Occurrence of Adverse Events in Patients with Acute Coronary Syndrome

Association of Myocardial Injury With Serum Procalcitonin Levels in Patients With ST-Elevation Myocardial Infarction

Differential gene expression patterns in ST-elevation Myocardial Infarction and Non-ST-elevation Myocardial Infarction

Contact Info

Product

Resources

About