Usefulness of several biomarkers in the management of septic patients: C-reactive protein, procalcitonin, presepsin and mid-regional pro-adrenomedullin

Enguix-Armada, Alfredo; Escobar-Conesa, R; Torre, A García-de la; Torre-Prados, M. V. de la

doi:10.1515/cclm-2015-0243

Cited by 61 publications

(49 citation statements)

References 19 publications

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“…Procalcitonin (PCT), which is a novel marker of inflammation and infection, has been widely investigated for its prognostic value in septic patients. Although studies have produced conflicting results [30][31][32][33][34][35][36], Tasdelen Fisgin et al [30] and Hensler et al [32] demonstrated that neopterin was a better prognostic factor than PCT in patients with sepsis.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis

Bavunoğlu

Genc

Konukoğlu

et al. 2016

J Infect Dev Ctries

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Introduction: Sepsis is a complex inflammatory syndrome with diverse etiology and wide spectrum of severity. The aim of this study was to investigate whether inflammatory mediators, in comparison with oxidative parameters, are associated with severity of sepsis. Methodology: Plasma neopterin, adenosine deaminase (ADA), vascular cell adhesion molecule (VCAM), intracellular adhesion molecule (ICAM), interleukin (IL)-1, IL-6, and tumor necrosis factor alpha (TNF-α), as inflammatory mediators, and serum nitric oxide (NOx), nitrotyrosine (NT), oxidized LDL (oxLDL) levels, serum paraoxonase 1 (PON1) activity, and erythrocyte glutathione (GSH) levels as oxidative stress parameters of 12 patients with mild sepsis, 25 patients with severe sepsis, and 20 healthy control subjects were evaluated. NOx, GSH levels and PON1 activity were determined by colorimetric methods, whereas neopterin, VCAM, ICAM, IL-1, IL-6, TNF-α, NT, and oxLDL levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: All parameters in mild and severe sepsis were significantly different from those of healthy subjects, except ADA activities. Patients with severe sepsis exhibited higher IL-6, TNF-α, NT, and oxLDL levels than patients with mild sepsis. GSH (98%, 98%), oxLDL (98%, 98%), VCAM-1 (99%, 99%), and ICAM-1 (99%, 99%) have much more sensitivitiy and specificity in sepsis. Conclusions: Our results suggest that the oxidative stress and inflammatory response in patients with sepsis were increased and that serum IL-6, TNF-α, NT, and oxLDL levels were correlated with the severity of sepsis. Therefore, increases in these parameters may contribute to the dysfunction or failure of one or more organs, or even death, in sepsis.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis

Bavunoğlu

Genc

Konukoğlu

et al. 2016

J Infect Dev Ctries

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“…Enguix-Armada et al [48] in a 388-patient cohort assessed whether the combination of CRP, PCT, presepsin and MR-proADM measured in the first 24 hours after ICU admission allows better management of septic patients. In their results PCT showed the highest AUC (0.989) as compared with the rest of the biomarkers (P < 0.01).…”

Section: Role Of Mid-regional Fragment Of Pro-adrenomedullin In Sepsismentioning

confidence: 99%

Sepsis diagnosis and monitoring – procalcitonin as standard, but what next?

Mierzchała-Pasierb¹,

Lipińska-Gediga²

2019

ait

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Sepsis is a life-threatening organ dysfunction caused by a systemic altered host response to infection. According to the newest guidelines the sepsis treatment should be personalized and based on an approach specified by use of biomarkers to tailor therapy to each patient's needs. The main features of such biomarkers should be high specificity, sensitivity and ability to monitor the progress of sepsis. There is limited application of procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) for reaching this target, because of their secretion during non-infectious processes. The purpose of this review was to introduce four biomarkers, i.e. kallistatin, testican-1, presepsin and mid-regional pro-adrenomedullin, and compare their usefulness in diagnosing sepsis with PCT, CRP and IL-6.

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“…is well established that presepsin is a useful marker in the diagnosis of sepsis [1,[6][7][8][9]. Studies on comparison of presepsin with conventional biomarkers (C-reactive protein [CRP], procalcitonin [PCT], etc.)…”

Section: Structure and Mechanism Of Presepsinmentioning

confidence: 99%

“…Godnic et al [30] investigated expression of CD64 on neutrophils Brought to you by | Stockholms Universitet Authenticated Download Date | 10/5/15 9:09 AM [19] 388 patients in ICU Has the highest AUC Enables the difference between Grampositive and Gram-negative bacteria Superior when combined with CRP and MR-proADM [6] 47 patients with SIRS, septic shock and sepsis Determines possible infection Predicts SIRS severity and distinguishes between sepsis and severe sepsis or septic shock Determines possible infection [30] 39 patients of nephrolithiasis who were diagnosed as SIRS Higher diagnostic value [28] Reports of 4 cases with renal dysfunction High, even infection does not exist [26] 19 newborns with LOS Useful for the diagnosis of LOS and monitoring the response to treatment [20] 191 patients with SIRS Superior in diagnosis of DIC [23] Review Better sensitivity and specificity in the diagnosis of sepsis [1] 116 patients with sepsis or septic shock Better diagnostic and prognostic value [29] Comparison of infection and non-infection groups Better in diagnosis and treatment of bacterial sepsis [10] Review Superior in diagnosing sepsis, assessing the severity of the disease and providing a prognostic evaluation of patient outcome [16] 21 patients in ICU with sepsis Returns to normal levels during the transient remission phase Remains high during the transient remission phase.…”

Section: Presepsin and Intensive Carementioning

confidence: 99%

Presepsin (sCD14-ST) as a biomarker of sepsis in clinical practice and in emergency department: a mini review

Erenler

Yardan

2015

LaboratoriumsMedizin

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Presepsin is a 13-kDa protein that is a fragment of CD14 with truncated N-terminal, the receptor for lipopolysaccharide (LPS)/LPS-binding protein complexes. It is a novel marker being sought in many diseases such as sepsis, kidney failure, disseminated intravascular coagulation, etc. In this review, we aimed to clarify its utility in critical diseases and availability in critical care settings such as emergency departments and intensive care units.

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Usefulness of several biomarkers in the management of septic patients: C-reactive protein, procalcitonin, presepsin and mid-regional pro-adrenomedullin

Abstract: PCT, MR-proADM and presepsin are complementary markers that could be of great help in the management of septic patients when they are measured in the first 24 h after ICU admission.

Cited by 61 publications

References 19 publications

Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis

Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis

Sepsis diagnosis and monitoring – procalcitonin as standard, but what next?

Presepsin (sCD14-ST) as a biomarker of sepsis in clinical practice and in emergency department: a mini review

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