Usefulness of sodium hyaluronate solution in colorectal endoscopic mucosal resection

Kishihara, Teruhito; Chino, Akiko; Uragami, Naoyuki; Yoshizawa, Natsuko; Imai, Mizuka; Ogawa, Tadao; Igarashi, Masahiro

doi:10.1111/j.1443-1661.2012.01244.x

Cited by 35 publications

(23 citation statements)

References 12 publications

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“…The basic information about the publications, the participants, and the lesions was described in Table 1 . The methodological method assessment showed that 7 RCTs reached a level of A [ 10 – 12 , 15 , 16 , 19 , 20 ], 2 RCTs reached a level of B [ 13 , 17 ], and 2 RCTs reached a level of C [ 14 , 18 ] ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Submucosal Injection Solution for Endoscopic Resection in Gastrointestinal Tract: A Traditional and Network Meta-Analysis

Huai

Wei

Jiang

et al. 2015

Gastroenterology Research and Practice

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Objective. To explore and define the current optimal submucosal injection solution used in ESD and EMR for gastrointestinal tract neoplasms in terms of clinical outcomes and other aspects. Methods. PubMed, Cochrane Library, Embase, and clinical trials register center were searched with terms of “endoscopic resection” and “submucosal injection solution” to identify relevant randomized controlled trials (RCTs). Both direct comparison using traditional meta-analysis method and indirect comparison using network meta-analysis method were performed. Results. A total of 11 RCTs with 1152 patients were included. Meta-analysis showed that, compared with normal saline, other submucosal injection solutions induced a significant increase in terms of en bloc resection rate (I 2 = 0%, OR = 2.11, 95% CI (1.36, 3.26), and P = 0.008) and complete resection rate (I 2 = 0%, OR = 2.14, 95% CI (1.41, 3.24), and P = 0.0003); and there was no significant difference in the incidence of total complications (I 2 = 0%, OR = 0.87, 95% CI (0.59, 1.29), and P = 0.49). Conclusions. Other newly developed submucosal injection solutions significantly increased en bloc resection rate and complete resection rate and decreased bleeding rate and finical cost of endoscopic resection in gastrointestinal tract, while current evidence did not find the difference between them, which need to be explored by further studies.

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Section: Resultsmentioning

confidence: 99%

Submucosal Injection Solution for Endoscopic Resection in Gastrointestinal Tract: A Traditional and Network Meta-Analysis

Huai

Wei

Jiang

et al. 2015

Gastroenterology Research and Practice

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“…23,24 However, despite the promising results of the aforementioned reports, their efficacy in preventing PPB is still a matter of debate.…”

Section: Discussionmentioning

confidence: 97%

Polidocanol injection decreases the bleeding rate after colon polypectomy: a propensity score analysis

Facciorusso

Maso

Antonino

et al. 2015

Gastrointestinal Endoscopy

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“…Therefore, the mucosal lift flattens rather quickly, and multiple injections are needed. 5 10 Sodium hyaluronate is a macromolecular polysaccharide composed of d-glucuronate and N-acetyl-d-glucosamine, which is found in human connective tissues and body fluids. 3 11 It is not antigenic or toxic in humans, and does not cause tissue damage.…”

Section: Discussionmentioning

confidence: 99%

“… 8 12 Previous studies have demonstrated the usefulness of sodium hyaluronate as a submucosal injection solution. 5 10 11 12 13 14 15 Yamamoto et al 16 showed that submucosal injection of 0.5% sodium hyaluronate is a reliable method, with a high en bloc resection rate (76%) and complete resection rate (77%) in gastric neoplasms. Hyun et al 17 reported that mucosal elevation lasted longer with 0.1% sodium hyaluronate than with NS in their study with fresh mongrel transverse colon.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Ready-to-Use 0.4% Sodium Hyaluronate (Endo-Ease) in the Endoscopic Resection of Gastrointestinal Neoplasms

et al. 2015

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Background/AimsCommercially available sodium hyaluronate solutions are usually too thick to inject through catheters and need dilution with normal saline (NS) before use, which increases the risk of contamination. We evaluated the usefulness of ready-to-use 0.4% sodium hyaluronate, Endo-Ease (EE; UNIMED Pharm. Inc., Seoul, Korea).MethodsWe performed a prospective multicenter randomized study from May 2011 to September 2012. Patients requiring endoscopic resection (ER) for gastric or colorectal neoplasm at two referral hospitals were enrolled.ResultsOne hundred fifty-four patients (72 with a gastric neoplasm and 82 with a colorectal neoplasm) were included in intention-to-treat analysis. Thirty-seven gastric neoplasms and 43 colorectal neoplasms were enrolled in the EE group. The usefulness rate was significantly higher in the EE group than in the NS group (89.2% vs. 60.0% for gastric neoplasms and 95.3% vs. 67.7% for colorectal neoplasms, p<0.001). In the EE group, the ease of mucosal resection was significantly higher than in the NS group (p<0.001). The injected volume was smaller in the EE group than in the NS group (p<0.05).ConclusionsThe use of EE reduced the need for additional injections and improved the ease of ER. A submucosal injection of EE is useful for the ER of both gastric and colorectal neoplasms.

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Usefulness of sodium hyaluronate solution in colorectal endoscopic mucosal resection

Abstract: Use of two-fold diluted MucoUp facilitated colorectal EMR.

Cited by 35 publications

References 12 publications

Submucosal Injection Solution for Endoscopic Resection in Gastrointestinal Tract: A Traditional and Network Meta-Analysis

Submucosal Injection Solution for Endoscopic Resection in Gastrointestinal Tract: A Traditional and Network Meta-Analysis

Polidocanol injection decreases the bleeding rate after colon polypectomy: a propensity score analysis

Usefulness of Ready-to-Use 0.4% Sodium Hyaluronate (Endo-Ease) in the Endoscopic Resection of Gastrointestinal Neoplasms

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