Usefulness of the Platelet-to-Lymphocyte Ratio in Predicting Angiographic Reflow After Primary Percutaneous Coronary Intervention in Patients With Acute ST-Segment Elevation Myocardial Infarction

Kurtul, Alparslan; Yarlıoğlueş, Mikail; Murat, Sani Namık; Ergün, Gökhan; Duran, Mustafa; Kasapkara, Hacı Ahmet; Demirçelik, Muhammed Bora; Çetın, Mustafa; Öcek, Adil Hakan

doi:10.1016/j.amjcard.2014.04.045

Cited by 112 publications

(93 citation statements)

References 27 publications

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“…Platelet-large cell ratio (P-LCR) and platelet distribution width (PDW) have also been associated with impaired reperfusion in patients with STEMI [3,4]. In recent years, platelet-to-lymphocyte ratio (PLT/LYM) and platelet-to neutrophil ratio (PLT/NEU) have been investigated as predictors of no-reflow in STEMI [5].…”

Section: Introductionmentioning

confidence: 99%

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Hadadi

Șuș

Lakatos

et al. 2015

Revista Romana De Medicina De Laborator

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Coronary chronic total occlusion (CTO) is caused by organized thrombi or atherosclerotic plaque progression. The presence of a CTO is an independent predictor of mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI). Platelets have a crucial role in the pathophysiology of atherosclerosis. The aim of this retrospective study was to investigate platelet indices as predictors of CTO in patients with STEMI treated with primary percutaneous coronary intervention (pPCI). A total number of 334 patients admitted for STEMI between January 2011 and December 2013 were included and divided in two groups based on the presence of CTO (48 patients in CTO+ group, 286 patients in CTO-group). Platelet count, mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio (P-LCR), lymphocyte and neutrophil count determined on admission were analyzed. MPV was larger in patients with CTO compared with patients without CTO (p=0.02), as were PDW (p=0.03) and P-LCR (p=0.01). Platelet-to-lymphocyte ratio (PLT/LYM) was lower in patients with

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Section: Introductionmentioning

confidence: 99%

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Hadadi

Șuș

Lakatos

et al. 2015

Revista Romana De Medicina De Laborator

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“…Therefore both NLR and PLR are parameters related to the inflammatory reaction. Recent studies have demonstrated that NLR and PLR is associated with adverse cardiovascular outcome (13,23). They are combined indices reflecting both the proinflammatory/procoagulant status which may provide an additional information to both disease severity as well as mortality.…”

Section: Discussionmentioning

confidence: 99%

Admission Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio as a predictor of mortality in patients with Subarachnoid Hemorrhage

Yılmaz¹,

Özkul²

2018

TÃ¼rk Beyin Damar Hast Derg

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INTRODUCTION: Inflammation is associated with the pathogenesis of subarachnoid hemorrhage (SAH) which is a serious disease with high mortality. NLR and PLR as novel inflammatory markers may serve as predictors of clinical severity and mortality in patients with SAH. METHODS: Medical records of adult SAH patients who were admitted to our Neurology and Neurosurgery Departments were investigated. Clinical, neuroradiological, laboratory, and follow-up data were collected from electronic database. Admission complete blood count values including hemoglobin, leukocyte, neutrophil, platelet and mean platelet volume, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were also studied. Fisher score and mortality rates were also evaluated. RESULTS: A total of 152 patients with a mean age of 52.94±17.04 (20-104) years, (94 (%61.8) females and 58 (38.2%) males) with SAH were included in the study. The patients were divided into two groups: aneurysmal (group 1, n:99) and nonaneurysmal SAH (group 2, n:53). In comparison of complete blood count parameters we found lower lymphocyte and higher neutrophil, NLR and PLR values in aneurysmal SAH patients who had also higher Fisher scores and mortality rate. There were also correlations between Fisher score and leukocyte, neutrophil, lymphocyte, NLR and PLR values. We also found that advanced age and higher NLR, PLR values are significantly related to mortality rates independent of presence of aneurysm. DISCUSSION and CONCLUSION: Aneurysmal SAH patients had lower lymphocyte and higher neutrophil, NLR, PLR values with higher mortality rates and disease severity. Additionally advanced age and higher NLR, PLR values were significantly related to mortality rates independent of presence of aneurysm. We believe that NLR and PLR can be used as simple parameters to evaluate severity of SAH and short term mortality in clinical practice.

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“…Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not treated appropriately [1]. During last 20 years clinical investigations have demonstrated an important correlation between ambulatory blood pressure monitoring readings and prevalence and extent of cardiovascular events [11]. Resistant hypertension is defined as resistance to treatment when a therapeutic strategy that includes lifestyle modification plus a diuretic and two different classes of antihypertensive drugs at adequate doses fails to lower systolic value to 140 mmHg and diastolic blood pressure value to 90 mmHg [10].…”

Section: Discussionmentioning

confidence: 99%

Relation of neutrophil/lymphocyte ratio to resistant hypertension

Dağlı

Doğdu

Şenarslan³

et al. 2016

Eur Res J

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Objectives. Resistant hypertension has unfavourable effects on cardiovascular and other systems. The aim of this study was to investigate the association of neutrophil/lymphocyte (N/L) ratio and resistant hypertension. Methods. A total of 140 patients were included in the study. Ambulatory 24-hour blood pressure monitoring, transthoracic echocardiography and blood sample analyzing were performed in all patients. There were 60 patients with resistant hypertension group (mean age=55.1±9.7 years) and 80 patients with non-resistant hypertension group (mean age=56.8±14.1 years). Results. Mean neutrophil levels were significantly higher in resistant hypertension group (71.7±6.1% vs. 65.9±5.4%, p<0.001), while lymphocyte levels were significantly higher in non-resistant hypertension group (22±4.7% vs. 17.5±4. 1%, p<0.001). N/L ratio was significantly higher in resistant hypertension group (4.3±1.2 vs. 3.1±0.9, p<0.001). In multivariate analysis, diabetes mellitus (odds ratio [OR]=2.857; 95% confidence interval [CI], 1. 349-6.053; p=0.006), N/L ratio (OR=2.699; 95% CI, 1. p<0.001) and obesity (OR=3.429; 95% CI, p=0.001) were independent predictors of resistant hypertension. Conclusion. The N/L ratio, which is cheaply and easily measurable laboratory data, is independently associated with resistant hypertension.Eur Res J 2016;2(3):211-218

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Usefulness of the Platelet-to-Lymphocyte Ratio in Predicting Angiographic Reflow After Primary Percutaneous Coronary Intervention in Patients With Acute ST-Segment Elevation Myocardial Infarction

Cited by 112 publications

References 27 publications

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Platelet indices and platelet-to-lymphocyte ratio predict coronary chronic total occlusion in patients with acute ST-elevation myocardial infarction

Admission Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio as a predictor of mortality in patients with Subarachnoid Hemorrhage

Relation of neutrophil/lymphocyte ratio to resistant hypertension

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