Usefulness of transstenotic coronary pressure gradient measurements during diagnostic catheterization

Ganz, Patricia A.; Abben, Richard; Friedman, Peter L.; Garnic, J D; Barry, William H.; Levin, David C.

doi:10.1016/0002-9149(85)90716-7

Cited by 47 publications

(9 citation statements)

References 23 publications

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“…Several authors (1,24,25,27,30,40) have described the use of catheters to assess the hemodynamic significance of coronary artery stenoses. The use of a single guide wire has been extended to measurement of physiological parameters, such as the fractional flow reserve (FFR) and coronary flow reserve (CFR) (18,23,36,43), for simultaneous evaluation of epicardial coronary disease and distal microvascular disease in clinical settings.…”

mentioning

confidence: 99%

Delineating the guide-wire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements

Roy¹,

Banerjee²,

Back³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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mentioning

confidence: 99%

Delineating the guide-wire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements

Roy¹,

Banerjee²,

Back³

et al. 2005

American Journal of Physiology-Heart and Circulatory Physiology

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“…Recent studies have suggested that percent diameter narrowing may not accurately reflect coronary flow reserve since flow is affected by other dimensions such as length and absolute radius (1-3). Accordingly, several investigators have suggested other criteria for successful angioplasty that rely on indirect measures of perfusion reserve (13)(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…Ganz et al have suggested that provocation of a high transstenotic pressure gradient by intracoronary contrast injec tion is a useful measure of the significance of moderate stenoses and resolution of these induced gradients in dicates successful angioplasty (13). However, this ap proach may be limited since the 2.0 F catheter does not cross the stenosis in as many as 20% of patients.…”

Section: Discussionmentioning

confidence: 99%

Changes in Myocardial Perfusion Reserve after PTCA: Noninvasive Assessment with Positron Tomography

Goldstein

Kirkeeide²,

Smalling³

et al. 1988

Investigative Radiology

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The effect of percutaneous transluminal coronary angioplasty (PTCA) on myocardial perfusion reserve has not been previously determined. Accordingly, 11 patients underwent positron imaging with [13N]ammoniaor 82Rbat rest and following dipyridamole + handgrip stress before and after PTCA. The ratio of stress to rest activity (S:R) was determined for each region of interest. Relative myocardial perfusion reserve by positron tomography (RMPR) was calculated by dividing S:R of the stenotic area by a corresponding value from a normal reference area of the same patient. Automated quantitative coronary arteriography was used to objectively measure the percent diameter (%D) and the percent area narrowing (%A) of the stenoses. In nine patients with successful PTCA, %D and %A improved (68 Â±10 to 49 Â± 15% and 92 Â±3 to 72 Â±5%) and RMPR increased from 0.79 Â±0.07 to 0.96 Â±0.05. In the two patients in whom PTCA was unsuccessful, RMPR was unchanged. Changes in RMPR correlated inversely with changes in %D (r = -0.68) and %A (r = -0.92) and directly with improved coronary flow reserve derived from all stenosis measurements (r = 0.73, p < 0.001 for each). This study suggests that dipyridamole + handgrip stress imaging with PET can be used to assess changes in myocardial perfusion reserve before and after PTCA with the potential for determining restenosis noninvasively.

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“…In one baboon a 3-french Gruentzig catheter was passed through the Judkins catheter and consequently through the stenotic area. However, transstenotic pressure gradient measurement seems to be o f limited value in cases of severe stenosis [7],…”

Section: Implantation Proceduresmentioning

confidence: 99%

Coronary Artery Plaque Rapidly Induced by Local Electromagnetic Stimulation in the Baboon

Breuer¹,

Fincham

Hinrichsen³

et al. 1989

Eur Surg Res

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A reliable method has been developed to produce stenosis of the right coronary artery of baboons as a consequence of electrostimulation of the vessel at a chosen position. At that site a pair of electrodes were implanted and activated with a train of 9-volt pulses (length: 10 ms, separation: 100 ms) for 30 min, 5 days/week, up to 6 weeks. 13 animals were included in the experiment, 2 of those served as controls. Pathohistologically the structure of the artificially produced constrictions is similar to atherosclerotic lesions. On average the stenoses occupied 55% of the available lumen; total occlusion and no stenosis were observed in 1 case each.

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Usefulness of transstenotic coronary pressure gradient measurements during diagnostic catheterization

Cited by 47 publications

References 23 publications

Delineating the guide-wire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements

Delineating the guide-wire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements

Changes in Myocardial Perfusion Reserve after PTCA: Noninvasive Assessment with Positron Tomography

Coronary Artery Plaque Rapidly Induced by Local Electromagnetic Stimulation in the Baboon

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