Using adult Aedes aegypti females to predict areas at risk for dengue transmission: A spatial case-control study

Parra, Maisa Carla Pereira; Fávaro, Eliane Aparecida; Dibo, Margareth Regina; Eiras, Álvaro Eduardo; Kroon, Erna Geessien; Teixeira, Mauro Martins; Nogueira, Maurício Lacerda; Neto, Francisco Chiaravalloti

doi:10.1016/j.actatropica.2018.02.018

Cited by 21 publications

(28 citation statements)

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“…Moreover, the majority of those studies used immature Aedes indices to assess the infestation level (density) in the study area [ 61 , 62 ]. Nevertheless, a study in Sao Paulo, Brazil demonstrated a strong association between numbers of female Aedes collected over a fortnight and dengue incidence [ 89 ]. Their findings were obtained after the re-introduction of DENV serotype 3, to which the majority of the population were susceptible, thus facilitating the assessment of entomological risk factors.…”

Section: Discussionmentioning

confidence: 99%

Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand

et al. 2020

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Background/Objectives Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vector abundance and dengue transmission risk. This study aims to identify entomological and immunological indices capable of discriminating between dengue case and control (non-case) houses, based on the assessment of candidate indices, as well as individual and household characteristics, as potential risk factors for acquiring dengue infection. Methods This prospective, hospital-based, case-control study was conducted in northeastern Thailand between June 2016 and August 2019. Immature and adult stage Aedes were collected at the houses of case and control patients, recruited from district hospitals, and at patients’ neighboring houses. Blood samples were tested by RDT and PCR to detect dengue cases, and were processed with the Nterm-34 kDa salivary peptide to measure the human immune response to Aedes bites. Socioeconomic status, and other individual and household characteristics were analyzed as potential risk factors for dengue. Results Study findings showed complex relationships between entomological indices and dengue risk. The presence of DENV-infected Aed es at the patient house was associated with 4.2-fold higher odds of dengue. On the other hand, Aedes presence (irrespective of infectious status) in the patient’s house was negatively associated with dengue. In addition, the human immune response to Aedes bites, was higher in control than in case patients and Aedes adult abundance and immature indices were higher in control than in case houses at the household and the neighboring level. Multivariable analysis showed that children aged 10–14 years old and those aged 15–25 years old had respectively 4.5-fold and 2.9-fold higher odds of dengue infection than those older than 25 years. Conclusion DENV infection in female Aedes at the house level was positively associated with dengue infection, while adult Aedes presence in the household was negatively associated. This study highlights the potential benefit of monitoring dengue viruses in Aedes vectors. Our findings suggest that monitoring the presence of DENV-infected Aedes mosquitoes could be a better indicator of dengue risk than the traditional immature entomological indices.

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Section: Discussionmentioning

confidence: 99%

Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand

et al. 2020

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“…The risk of dengue transmission is influenced by various factors, including trade of goods and human mobility, population density, urbanization, climate, presence of invasive populations of Aedes vectors and pathogens, virus evolution, density of competent vectors, and ineffective vector control strategies ( 18 , 19 ). While an efficient vaccine is still under research, entomological surveillance and vector control remain the only ways to prevent and control dengue transmission ( 19 – 21 ). Therefore, WHO recommends a routine vector surveillance to provide a quantifiable measurement of dengue vector fluctuations and their geographical distribution for assessing the risk of outbreaks and to determine vector control interventions ( 2 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

Stegomyia Indices and Risk of Dengue Transmission: A Lack of Correlation

Garjito

Hidajat

Kinansi

et al. 2020

Front. Public Health

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Dengue is present in 128 countries worldwide and is still expanding. There is currently no treatment or universally approved vaccine available. Therefore, prevention and control of mosquito vectors remain the most efficient ways of managing the risk of dengue outbreaks. The Stegomyia indices have been developed as quantitative indicators of the risk of dengue outbreaks. However, conflictual data are circulating about their reliability. We report in this article the first extensive study on Stegomyia indices, covering 78 locations of differing environmental and socioeconomic conditions, climate, and population density across Indonesia, from West Sumatra to Papua. A total of 65,876 mosquito larvae and pupae were collected for the study. A correlation was found between incidence and human population density. No correlation was found between the incidence of dengue and the Stegomyia indices.

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“…This analysis is based on mapping the intrinsic growth rate observed for female Aedes mosquitoes. Recent research shows the adequacy and sometimes the superiority of female mosquito-based indices instead of egg and larvae-based measures to predict dengue risk ( Parra et al., 2018 ). Certainly the spatial and temporal ranges found in this work need to be considered carefully before any generalisation (unless as prior-information for future Bayesian framework).…”

Section: Discussionmentioning

confidence: 99%

Using the intrinsic growth rate of the mosquito population improves spatio-temporal dengue risk estimation

et al. 2020

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Highlights Vector indices are often poor predictors of geographic disease risk. When longitudinal vector surveillance data is available, vector population dynamics parameters can be estimated. Vector population dynamics are investigated as a measure of disease risk. In this work we have shown that mosquito intrinsic growth rate has a larger predictive accuracy for dengue incidence than mosquito abundance. In the light of this result we encourage vector surveillance and control agencies/scientist to explore the use of intrinsic growth rate as index for disease risk.

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Using adult Aedes aegypti females to predict areas at risk for dengue transmission: A spatial case-control study

Cited by 21 publications

References 37 publications

Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand

Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand

Stegomyia Indices and Risk of Dengue Transmission: A Lack of Correlation

Using the intrinsic growth rate of the mosquito population improves spatio-temporal dengue risk estimation

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