Municipal solid waste incineration (MSWI) y ash treated with toxicity metals holds enormous potential for constructure use to economize on resources and protect environment. To reach the goal, this study investigated the effects of sintering conditions on leaching characteristic of heavy metals for MSWI y ash, especially Cr, Cr 6+ , Ag, and Ba, with orthogonal and Box-Benhnken design experiment, which considered grain size (D 50 =30, 45, and 60μm), uxing agent (CaO=0, 2.5, and 5%), setting temperature (1000, 1050, and 1100℃), and setting time (120, 180, and 240min). The mechanism of immobilization for heavy metals was also discussed through the analyses of morphological characterizations, mineral phases, chemical composition and leaching values of metals. The results indicated that changing grain size and adding uxing agent of CaO has positive in uence on reducing the leaching of heavy metals compared with direct sintering. The leaching values of As, Pb, Cd, Cu, Ni, Zn, Mn, Hg, Be, Se and uoride are not detected after sintering. Ideal sintered condition with desirability of 1.00 was predicted and optimized by Box-Benhnken response method in grain size of D 50 =30μm, uxing agent of CaO=5%, setting temperature=1050℃, and setting time=180min, which immobilized Cr, Cr 6+ , Ag, and Ba lower than the limitation of standards. Actual experiment was consistent with numerical optimization. Furthermore, the model of leaching characteristic for heavy metals in MSWI y ash was established to better explain the mechanism during sintering.