Using diazepam and atropine before strabismus surgery to prevent postoperative nausea and vomiting: a randomized, controlled study

Özcan, Altan Atakan; Güneş, Yılmaz; Haciyakupoğlu, Gülhanım

doi:10.1016/s1091-8531(03)00016-8

Cited by 16 publications

(6 citation statements)

References 17 publications

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“…They observed that the reversal of neuromuscular blockade with atropine and neostigmine was associated with a lower incidence of postoperative emesis compared with glycopyrrolate and neostigmine in children undergoing tonsillectomy [21]. Additionally, a study done by Ozcan et al concluded that the premedication with diazepam and atropine sulfate decreases nausea and vomiting after strabismus surgery [22].…”

Section: Discussionmentioning

confidence: 99%

Intravenous dexamethasone combined with intrathecal atropine to prevent morphine-related nausea and vomiting after cesarean delivery: A randomized double-blinded study

Abdalla

Kamel

Farrag

2019

Egyptian Journal of Anaesthesia

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Background: Intrathecal morphine can be considered as a gold standard for analgesia following cesarean section (CS), which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after CS. Methods: 120 parturient undergoing elective CS under spinal anesthesia were randomized into three groups. Dexamethasone group (D): Received intrathecal hyperbaric bupivacaine (0.5% in 2 ml) mixed with morphine (200 µg in 0.5 ml) and normal saline (0.5 ml as placebo) and intravenous (iv) dexamethasone (8 mg in 2 ml). Atropine group (A): Received hyperbaric bupivacaine (0.5% in 2 ml) mixed with morphine (200 µg in 0.5 ml) and atropine (100 µg in 0.5 ml), in addition to iv normal saline (2 ml as placebo). Dexamethasone and Atropine group (DA): Received intrathecally as group A, and iv dexamethasone (8 mg in 2 ml). Follow-up of both nausea and vomiting was done during the first 24 hours postoperatively. Results: Nausea was noticed in 7 patients (17.5%) in group D, 8 patients (20%) in group A, and one patient (2.5%) group DA, with significant differences between DA and D (p = 0.025) and DA and A (p = 0.013). Regarding vomiting, there were 5 patients (12.5%) in group D, 4 patients (10%) in group A only, with significant differences between DA and D (p = 0.021) and DA and A (p = 0.041). Conclusions: Combination of intravenous dexamethasone and intrathecal atropine has additive antiemetic effect after spinal anesthesia for cesarean delivery using bupivacaine and morphine.

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Section: Discussionmentioning

confidence: 99%

Intravenous dexamethasone combined with intrathecal atropine to prevent morphine-related nausea and vomiting after cesarean delivery: A randomized double-blinded study

Abdalla

Kamel

Farrag

2019

Egyptian Journal of Anaesthesia

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“…Second, the two previous studies used midazolam 16 and diazepam 18 as premedications, unlike this study. These two premedications are known to prevent PONV, 27,28 which may have confounded the results. Third, the two previous studies used ondansetron, whereas this study used palonosetron, which is known to be effective in the prevention of PONV.…”

Section: Discussionmentioning

confidence: 99%

Effect of Palonosetron, Dexamethasone, or Palonosetron and Dexamethasone in Postoperative Nausea and Vomiting in Highly Susceptible Thyroidectomy Patients: A Randomized Trial

Kim

Kang

Choi

et al. 2016

International Surgery

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Our study aimed to compare the efficacy of dexamethasone added to palonosetron to both palonosetron and dexamethasone monotherapy for preventing postoperative nausea and vomiting in highly susceptible patients receiving opioid-based, intravenous patient-controlled analgesia after thyroidectomy. Nonsmoking women who underwent total thyroidectomy were randomly allocated to either the dexamethasone group (Group D), the palonosetron group (Group P), or to the dexamethasone plus palonosetron group (Group DP). The severity of nausea and pain, the number of episodes of vomiting, the administrations of rescue anti-emetics, and the side effects of the antiemetics were documented in the recovery room at 2, 4, 8, 12, 24, and 48 hours after surgery. The severity of nausea was lowest in Group DP, followed by Group P and Group D. But there was an overall difference only between Group D and Group DP. The overall differences in the time to the first administration of the rescue antiemetic were observed in a Kaplan-Meier analysis (P ¼ 0.017), noting a significant difference between Group D and Group DP (P ¼ 0.003). The combination of dexamethasone and palonosetron decreased the severity of nausea and increased the time to the first antiemetic dose compared with using

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“…9,11,12,16,17 In addition, providing careful and detailed informed consent helps patients undergoing strabismus surgery to relax before surgery. However, we believe that the 8 postoperative symptoms that were investigated in this study cannot be completely alleviated by medications and informed consent.…”

Section: Discussionmentioning

confidence: 99%

Differences between patient expectations and actual strabismus surgery experience in adults

Ryu

Sohn

Ahn

2015

Canadian Journal of Ophthalmology

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Using diazepam and atropine before strabismus surgery to prevent postoperative nausea and vomiting: a randomized, controlled study

Cited by 16 publications

References 17 publications

Intravenous dexamethasone combined with intrathecal atropine to prevent morphine-related nausea and vomiting after cesarean delivery: A randomized double-blinded study

Intravenous dexamethasone combined with intrathecal atropine to prevent morphine-related nausea and vomiting after cesarean delivery: A randomized double-blinded study

Effect of Palonosetron, Dexamethasone, or Palonosetron and Dexamethasone in Postoperative Nausea and Vomiting in Highly Susceptible Thyroidectomy Patients: A Randomized Trial

Differences between patient expectations and actual strabismus surgery experience in adults

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