“…The widespread adoption and use of electronic health records (EHRs), driven by the Health Information Technology for Economic and Clinical Health Act (HITECH Act 2009) and integral to learning healthcare systems (Califf, Sanderson, and Miranda 2012; Institute of Medicine and National Academy of Engineering 2011), has made an unprecedented amount of information available not only for clinical care, but also for health-related research (Kukafka et al 2007;Menachemi and Collum 2011;National Research Council 2011;H€ ayrinen, Saranto, and Nyk€ anen 2008). EHRs are being increasingly used for research and clinical trial recruitment due to the depth and breadth of the information they contain as well as new technological tools to mine, assimilate, analyze, link, reproduce, and transmit information (Caine and Hanania 2013;Tan et al 2016;Wu et al 2016). For example, a process called "EHR phenotyping" allows researchers to identify cohorts of patients with precise attributes by applying highthroughput algorithms to EHR data to classify patients based on exact constellations of information (e.g., demographics, symptoms, diagnoses, procedures, laboratory values, vital signs, medications, lifestyle and environmental factors) (Hripcsak and Albers 2013;Boland, Hripcsak, et al 2013;Pathak, Kho, and Denny 2013;Richesson North Carolina (D); Mingo, West Virginia (M); and Quitman, Mississippi (Q) (Appendix A).…”