The usage of ethanol and two different mixtures of ethanol and gasoline (E85 and E65) was investigated on a modified diesel engine designed to work in a dual-fuel combustion mode with intake manifold alcohol injection. The tests were conducted at five operating points covering low, medium and high load and different engine speeds. Additionally, an engine-process simulation model was built for the test engine and selected operating points from the engine test bed measurements were analysed with it. The discussion of the simulation results allows an efficiency analysis and therefore a better understanding of the findings of the engine test stand experiments. With rising alcohol amount, a significant reduction of soot mass and particle count was observed at all operating points. At some load conditions, substituting diesel with ethanol, E65 or E85 led to a reduction of the NOx emissions; however, the real benefit concerning the nitrogen oxides was introduced by the mitigation of the soot-NOx trade-off. The indicated engine efficiency in dual-fuel mode showed an extended tolerance against high EGR rates. It was significantly improved with enhanced substitution ratios at high loads, whereas it dropped at low loads. Substituting diesel with manifold injected alcoholic fuels impressively reduced the engine CO 2 emissions at medium and high load operating points. Degrading combustion quality, irregular combustion phenomena and poor process controllability at low load and knock as well as auto-ignition at high load limited the maximum ethanol energy share to approximately 70% and 30%, respectively. Keywords Diesel engine • Dual fuel • Ethanol • Alcoholic fuel Abbreviations EtOH Ethanol E85 Mixture of 85 vol% ethanol and 15 vol% gasoline E65 Mixture of 65 vol% ethanol and 35 vol% gasoline CEC Certified test diesel fuel OP Operating point EGR Exhaust gas recirculation MFB Mass fraction burned CAaTDC Crank angle after top dead center c p Specific heat capacity at constant pressure c v Specific heat capacity at constant volume * A.