Manufacturing parameters of brake friction materials have a crucial impact on its friction and wear behavior. The effects of manufacturing parameters on wear have been modeled aiming at the optimization of facing behaviors. The influences of the five most important manufacturing parameters, such as molding pressure, molding time, molding temperature, heat-treatment temperature, and heat-treatment time, have been investigated. Their effects have been investigated on different formulations of the friction material and under different brake interface temperatures. The neuro-genetic optimization model was developed to be able to predict and optimize the effects of manufacturing parameters on the brake friction material wear.