Using Heterogeneous Hardware for Simultaneous Diagnostic and Therapeutic Ultrasound

Clegg, Harry R.; Carpenter, Thomas M.; McLaughlan, James R.; Freear, Steven; Cowell, David M. J.

doi:10.1109/ultsym.2019.8926163

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…This open platform allows the connection of 16 single-element transducers and can transmit and receive on all 16 channels simultaneously. The MACC, UARPII-16, and all six unfocused transducers were used to perform an experiment to assess the suitability of the entire setup for microbubble acoustic measurements [33]. Whilst the UARPII-16 was used in this instance, it could have been replaced with another multi-channel system providing access to the radio-frequency data from every channel [34] such as the NDT Vantage ™ (Verasonics ® , Kirkland, WA, USA) research solutions.…”

Section: Experiments Designmentioning

confidence: 99%

An Open Access Chamber Designed for the Acoustic Characterisation of Microbubbles

et al. 2022

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Microbubbles are used as contrast agents in clinical ultrasound for Left Ventricular Opacification (LVO) and perfusion imaging. They are also the subject of promising research in therapeutics as a drug delivery mechanism or for sonoporation and co-administration. For maximum efficacy in these applications, it is important to understand the acoustic characteristics of the administered microbubbles. Despite this, there is significant variation in the experimental procedures and equipment used to measure the acoustic properties of microbubble populations. A chamber was designed to facilitate acoustic characterisation experiments and was manufactured using additive manufacturing techniques. The design has been released to allow wider uptake in the research community. The efficacy of the chamber for acoustic characterisation has been explored with an experiment to measure the scattering of SonoVue® microbubbles at the fundamental frequency and second harmonic under interrogation from emissions in the frequency range of 1.6 to 6.4 MHz. The highest overall scattering values were measured at 1.6 MHz and decreased as the frequency increased, a result which is in agreement with previously published measurements. Statistical analysis of the acoustic scattering measurements have been performed and a significant difference, at the 5% significance level, was found between the samples containing contrast agent and the control sample containing only deionised water. These findings validate the proposed design for measuring the acoustic scattering characteristics of ultrasound contrast agents.

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Section: Experiments Designmentioning

confidence: 99%