Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance

Wang, Liming; Sun, Qiang; Wang, Xin; Wen, Tao; Yin, Jun‐Jie; Wang, Pengyang; Bai, Ru; Zhang, Xiangqian; Zhang, Luhua; Lu, An‐Hui; Chen, Chunying

doi:10.1021/ja511560b

Cited by 185 publications

(122 citation statements)

References 67 publications

(107 reference statements)

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“…We found that the local mild thermal stimulus and the triggered generation of free radicals by laser treatment enhanced the expression of heat shock factor-1 (HSF-1), which depressed the activation of NF- κ B pathways (figure 4) [114]. Importantly, the NF- κ B pathway is well known to regulate drug resistance using high expression of pump proteins in the cell membrane and low sensitivity to toxic chemotherapeutic drugs [114, 123]. As a result, local NIR irradiation can successfully depress resistant pathways to overcome drug resistance.…”

Section: Interaction Of Au Nps With Cellsmentioning

confidence: 99%

Interaction of gold nanoparticles with proteins and cells

Wang

et al. 2015

Science and Technology of Advanced Materials

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168

117

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Gold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application range may result in hazards to the environment and human health. Therefore, it is important to predict safety and evaluate therapeutic efficiency of Au NPs. It is necessary to establish proper approaches for the study of toxicity and biomedical effects. In this review, we first focus on the recent progress in biological effects of Au NPs at the molecular and cellular levels, and then introduce key techniques to study the interaction between Au NPs and proteins. Knowledge of the biomedical effects of Au NPs is significant for the rational design of functional nanomaterials and will help predict their safety and potential applications.

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Section: Interaction Of Au Nps With Cellsmentioning

confidence: 99%

Interaction of gold nanoparticles with proteins and cells

Wang

et al. 2015

Science and Technology of Advanced Materials

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168

117

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“…12,13 Comparatively, laser irradiation-assisted photothermal therapy (PTT) or photodynamic therapy (PDT) are non-invasive mode that can generate heats or free radicals at tumor site. [14][15][16] Photothermal therapy agents are capable of converting light energy into heat that causes a rise in the local temperature beyond 42 °C that consequently kill cancer cells. 17,18, 19 As a FDA-approved drug, indocyanine green (ICG) is attractive for localized hyperthermia that absorbs near infrared light (700-1000 nm) even in deep tissue 20,21 to generate heat.…”

Section: Introductionmentioning

confidence: 99%

Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging

Cao

Wang

Kou

et al. 2015

ACS Appl. Mater. Interfaces

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The combination of therapy and diagnosis has been emerging as a promising strategy for cancer treatment. To realize chemotherapy, photothermal therapy, and magnetic resonance imaging (MRI) in one system, we have synthesized a new magnetic nanoparticle (Gd@SiO2-DOX/ICG-PDC) integrating doxorubicin (DOX), indocyanine green (ICG), and gadolinium(III)-chelated silica nanospheres (Gd@SiO2) with a poly(diallyldimethylammonium chloride) (PDC) coating. PDC coating serves as a polymer layer to protect from quick release of drugs from the nanocarriers and increase cellular uptake. The DOX release from Gd@SiO2-DOX/ICG-PDC depends on pH and temperature. The process will be accelerated in the acidic condition than in a neutral pH 7.4. Meanwhile, upon laser irradiation, the photothermal effects promote DOX release and improve the therapeutic efficacy compared to either DOX-loaded Gd@SiO2 or ICG-loaded Gd@SiO2. Moreover, MRI results show that the Gd@SiO2-PDC nanoparticles are safe T1-type MRI contrast agents for imaging. The Gd@SiO2-PDC nanoparticles loaded with DOX and ICG can thus act as a promising theranostic platform for multimodal cancer treatment.

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“…[ 53 ] Compared with the most widely used carbon precursor for the HCS hosts (e.g., phenol formaldehyde resin, saccharide, and dopamine), polybenzoxazine (PB) has been largely overlooked although recent literature suggests that PB-based polymer is an interesting precursor for N-doped carbon nanostructures. [ 54,55 ] We demonstrate for the fi rst time that PB can be applied into the Stöber coating method for the templating synthesis of N-HCS with the controllable structure parameters.…”

mentioning

confidence: 97%

From Hollow Carbon Spheres to N‐Doped Hollow Porous Carbon Bowls: Rational Design of Hollow Carbon Host for Li‐S Batteries

Pei

Zang

et al. 2016

Advanced Energy Materials

507

339

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rapidly growing topic in the sulfur/carbon cathodes. [15][16][17][24][25][26][27][28][29][30] Although the porous structures of HCS favor the sulfur loading and electrolyte transport, the interaction between the nonpolar carbon shell and polar polysulfi de intermediates is not enough to suppress the dissolution of polysulfi de intermediates. More importantly, when used as the electrode materials, the large inner cavity of HCS usually results in the relatively low volumetric energy densities. Such an inherent drawback of HCS is undesirable for practical applications. [ 31,32 ] Following the development trend of the sulfur/carbon cathodes, the design of HCS should focus on the following aspects: (i) ultrahigh surface area to maximize the electrolyte permeation and interaction between HCS and sulfur/polysulfi des; (ii) heteroatom doping (e.g., nitrogen) to enhance the electrical conductivity of HCS and chemisorption between HCS and polysulfi de intermediates; (iii) shape optimization to improve conductive pathway and volumetric energy densities; (iv) facile and low-cost methodology to facilitate the practical applications.As a special class of hollow structures, bowl-like structure is an ideal methodology to increase the packing density of HCS. When used as the electrode materials, hollow carbon bowls (HCB) stacked within each other are also benefi cial to forming a favorable conductive pathway. However, there has been little success in using HCB to directly achieve high-performance energy storage components. [ 33,34 ] Recent research has indicated the unique biomedical applications of HCB. [35][36][37] Unfortunately, the reported HCB usually exhibit a low specifi c surface area (about 700-1000 m 2 g −1 ), which is much lower than HCS reported previously. [15][16][17][24][25][26][27][28][29] Since the utilization of chemical bonding between heteroatom doped carbon host and polysulfi de intermediates has been recently demonstrated as an effective way to further reduce the dissolution of polysulfi de intermediates, [38][39][40][41][42][43][44] the reported HCB with pristine carbon shell is diffi cult to meet the requirement for bonding polysulfi de intermediates. Therefore, the desirable HCB should not only inherit the advantages of HCS but also fulfi ll all above requirements for S/HCS cathodes. From the point of structure design, N-doped HCB (N-HCB) with high specifi c surface areas would open new opportunities for the sulfur/carbon cathodes. However, a new and effective methodology is the necessary prerequisite to the targeted N-HCB.Here, we present a facile route to synthesize N-doped HCS (N-HCS) and its N-HCB counterparts. Since the structure parameters of HCS can be precisely controlled by the prefabricated templates, hard-templating method is one of the most important routes to synthesize HCS. [45][46][47][48][49][50][51][52] From early Rechargeable lithium-sulfur (Li-S) batteries with the theoretical specifi c energy (≈2600 Wh kg −1 ) have attracted considerable attention due to its favorable prospect for futu...

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Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance

Cited by 185 publications

References 67 publications

Interaction of gold nanoparticles with proteins and cells

Interaction of gold nanoparticles with proteins and cells

Gadolinium(III)-Chelated Silica Nanospheres Integrating Chemotherapy and Photothermal Therapy for Cancer Treatment and Magnetic Resonance Imaging

From Hollow Carbon Spheres to N‐Doped Hollow Porous Carbon Bowls: Rational Design of Hollow Carbon Host for Li‐S Batteries

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