Using <i>In-Vivo</i> Fluorescence Imaging in Personalized Cancer Diagnostics and Therapy, an Image and Treat Paradigm

Ardeshirpour, Yasaman; Chernomordik, Victor; Capala, Jacek; Mohabatkar, Hassan; Zielinsky, Rafal; Griffiths, Gary L.; Achilefu, Samuel; Smith, Paul D.; Gandjbakhche, Amir

doi:10.1177/153303461101000605

Cited by 30 publications

(13 citation statements)

References 74 publications

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“…In the latter case, optical monitoring of drug release can be achieved by triggering not only the release (i.e., binding to the cell surface receptor) but also a fluorescent marker (29,30). Another approach for imaging and treating at the same time is using fluorescence lifetime for tumor receptor quantification (31). However, in this case, treatment is not achieved simultaneously with imaging.…”

mentioning

confidence: 99%

Implantable, multifunctional, bioresorbable optics

Tao

Kainerstorfer

Siebert

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

114

108

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Advances in personalized medicine are symbiotic with the development of novel technologies for biomedical devices. We present an approach that combines enhanced imaging of malignancies, therapeutics, and feedback about therapeutics in a single implantable, biocompatible, and resorbable device. This confluence of form and function is accomplished by capitalizing on the unique properties of silk proteins as a mechanically robust, biocompatible, optically clear biomaterial matrix that can house, stabilize, and retain the function of therapeutic components. By developing a form of high-quality microstructured optical elements, improved imaging of malignancies and of treatment monitoring can be achieved. The results demonstrate a unique family of devices for in vitro and in vivo use that provide functional biomaterials with built-in optical signal and contrast enhancement, demonstrated here with simultaneous drug delivery and feedback about drug delivery with no adverse biological effects, all while slowly degrading to regenerate native tissue.

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mentioning

confidence: 99%

Implantable, multifunctional, bioresorbable optics

Tao

Kainerstorfer

Siebert

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

114

108

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“…The higher uptake at the tumor site indicates its higher vascularization. The fluorescence intensity at the tumor and contralateral sites was normalized to the background intensity of the tumor area before injection (after [147]).…”

Section: Non-targeted Fluorescent Probesmentioning

confidence: 99%

Modern Trends in Imaging IX: Biophotonics Techniques for Structural and Functional Imaging,In Vivo

Ardeshirpour

Gandjbakhche

Najafizadeh

2012

Analytical Cellular Pathology

Self Cite

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In vivo optical imaging is being conducted in a variety of medical applications, including optical breast cancer imaging, functional brain imaging, endoscopy, exercise medicine, and monitoring the photodynamic therapy and progress of neoadjuvant chemotherapy. In the past three decades, in vivo diffuse optical breast cancer imaging has shown promising results in cancer detection, and monitoring the progress of neoadjuvant chemotherapy. The use of near infrared spectroscopy for functional brain imaging has been growing rapidly. In fluorescence imaging, the difference between autofluorescence of cancer lesions compared to normal tissues were used in endoscopy to distinguish malignant lesions from normal tissue or inflammation and in determining the boarders of cancer lesions in surgery. Recent advances in drugs targeting specific tumor receptors, such as AntiBodies (MAB), has created a new demand for developing non-invasive in vivo imaging techniques for detection of cancer biomarkers, and for monitoring their down regulations during therapy. Targeted treatments, combined with new imaging techniques, are expected to potentially result in new imaging and treatment paradigms in cancer therapy. Similar approaches can potentially be applied for the characterization of other disease-related biomarkers. In this chapter, we provide a review of diffuse optical and fluorescence imaging techniques with their application in functional brain imaging and cancer diagnosis.

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“…Optical imaging techniques have high potential in this application due to the ability for real-time noninvasive monitoring of the efficiency of photodynamic reaction in combination with compactness and economic efficacy. [23][24][25] Most of the studies employ fluorescence imaging (FI) allowing one to evaluate PS accumulation level, monitor PS photobleaching, and clarify the tumor border in oncologic applications. [26][27][28][29][30] Combination of FI with spectroscopy techniques allows for simultaneous monitoring of singlet oxygen production in the course of PDT procedure.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy with chlorin-based photosensitizer at 405 nm: numerical, morphological, and clinical study

et al. 2018

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Employment of chlorin-based photosensitizers (PSs) provides additional advantages to photodynamic therapy (PDT) due to absorption peak around 405 nm allowing for superficial impact and efficient antimicrobial therapy. We report on the morphological and clinical study of the efficiency of PDT at 405 nm employing chlorin-based PS. Numerical studies demonstrated difference in the distribution of absorbed dose at 405 nm in comparison with traditionally employed wavelength of 660 nm and difference in the in-depth absorbed dose distribution for skin and mucous tissues. Morphological study was performed at the inner surface of rabbit ear with histological examinations at different periods after PDT procedure. Animal study revealed tissue reaction to PDT consisting in edema manifested most in 3 days after the procedure and neoangiogenesis. OCT diagnostics was confirmed by histological examination. Clinical study included antimicrobial PDT of pharynx chronic inflammatory diseases. It revealed no side effects or complications of the PDT procedure. Pharyngoscopy indicated reduction of inflammatory manifestations, and, in particular cases, hypervascularization was observed. Morphological changes were also detected in the course of monitoring, which are in agreement with pharyngoscopy results. Microbiologic study after PDT revealed no pathogenic bacteria; however, in particular cases, saprophytic flora was detected.

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Using In-Vivo Fluorescence Imaging in Personalized Cancer Diagnostics and Therapy, an Image and Treat Paradigm

Cited by 30 publications

References 74 publications

Implantable, multifunctional, bioresorbable optics

Implantable, multifunctional, bioresorbable optics

Modern Trends in Imaging IX: Biophotonics Techniques for Structural and Functional Imaging,In Vivo

Photodynamic therapy with chlorin-based photosensitizer at 405 nm: numerical, morphological, and clinical study

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