Using Low-Calorie Orange Juice as a Dietary Alternative to Alkali Therapy

Large, Tim; Williams, James C.; Asplin, John R.; Krambeck, Amy E.

doi:10.1089/end.2020.0031

Cited by 15 publications

(21 citation statements)

References 18 publications

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“…Small prospective clinical studies found that orange, melon, grapefruit, and lemon juices increased urinary citrate levels [13][14][15][16][17][18][19][20][21]. Baia et al, for example, showed that citrate increased after 4 h of ingestion to 0.35 ± 0.15 vs. baseline of 0.22 ± 0.10 mg/mg creatinine in the melon group, 0.32 ± 0.17 vs. baseline of 0.14 ± 0.09 mg/mg creatinine in the orange group, and to 0.29 ± 0.21 vs. baseline of 0.15 ± 0.12 mg/mg creatinine in the lime group.…”

Section: Resultsmentioning

confidence: 99%

Role of Citrus Fruit Juices in Prevention of Kidney Stone Disease (KSD): A Narrative Review

Barghouthy

Somani

2021

Nutrients

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To explore the relationship between citrus fruit juices (oranges, grapefruits, and lemonades) and kidney stone disease (KSD). Methods: A systematic review was performed using the Medline, EMBASE, and Scopus databases, in concordance with the PRISMA checklist for all English, French, and Spanish language studies regarding the consumption of citrus fruit juices and the relationship to urinary stone disease. The main outcome of interest was the association of citrus fruit juices with KSD. Results: Thirteen articles met the criteria for inclusion in the final review. Three large epidemiological studies found that grapefruit juice was a risk factor for stone formation, while orange juice did not increase the risk for KSD. Ten small prospective clinical studies found that orange, grapefruit, and lemon juices all increased urinary citrate levels. Only orange and grapefruit juices had an alkalinizing effect and while lemon juice has a protective effect by raising urinary citrate levels, it lacked a significant alkalinizing effect on urine pH. Orange juice and grapefruit juices significantly increased urinary oxalate levels, while orange juice also had a high carbohydrate content. Conclusion: While orange juice seems to play a protective role against stone formation, grapefruit was found to raise the risk of KSD in epidemiological studies but had a protective role in smaller clinical studies. Lemon juice had a smaller protective role than orange juice. Larger amounts of, as well as more accurate, data is needed before recommendations can be made and a high carbohydrate content in these juices needs to be taken into consideration.

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Section: Resultsmentioning

confidence: 99%

Role of Citrus Fruit Juices in Prevention of Kidney Stone Disease (KSD): A Narrative Review

Barghouthy

Somani

2021

Nutrients

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“…Due to concerns over the high sugar and energy content and the lack of dietary fiber of orange juice, the nutritional advice is to opt for the whole fruit over the juice, to limit daily consumption of fruit juice to one serving and to dilute the juice with water [14]. A randomized crossover study of 10 healthy subjects under regular diet comparing a crystal light lemonade beverage and two low-calorie orange juice beverages noted a higher urine pH as the only significant change between the groups when participants consumed Kroger low-calorie orange juice beverage [57]. However, citrate excretion, a major urinary inhibitor of calcium oxalate stone formation, did not significantly differ between the groups.…”

Section: Fruit Juices and Fruit Juice Beveragesmentioning

confidence: 99%

“…However, citrate excretion, a major urinary inhibitor of calcium oxalate stone formation, did not significantly differ between the groups. Moreover, concerns over health risks associated especially with overconsumption and with certain artificial colorings, preservatives, sweeteners and additives, such as ascorbic acid and calcium, severely limit the health benefit of these beverages for kidney stone formers [57,58]. Compared to orange juice, lemon and lime juices were found to have higher citrate concentrations [61].…”

Section: Fruit Juices and Fruit Juice Beveragesmentioning

confidence: 99%

“…Although several studies in stone patients with or without hypocitraturia found a significant rise in urinary citrate excretion after the administration of lemonade [62][63][64][65], others failed to confirm the citraturic effects of regular lemonade [54,66,67]. Reasons for the variability in urinary citrate excretion with lemonade could be different degrees of dilution of pure lemon juice and the higher proportion of non-alkaline citric acid, which could have neutralized the alkali potential of citrate [57,68].…”

Section: Fruit Juices and Fruit Juice Beveragesmentioning

confidence: 99%

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Nutrition and Kidney Stone Disease

Siener

2021

Nutrients

176

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The prevalence of kidney stone disease is increasing worldwide. The recurrence rate of urinary stones is estimated to be up to 50%. Nephrolithiasis is associated with increased risk of chronic and end stage kidney disease. Diet composition is considered to play a crucial role in urinary stone formation. There is strong evidence that an inadequate fluid intake is the major dietary risk factor for urolithiasis. While the benefit of high fluid intake has been confirmed, the effect of different beverages, such as tap water, mineral water, fruit juices, soft drinks, tea and coffee, are debated. Other nutritional factors, including dietary protein, carbohydrates, oxalate, calcium and sodium chloride can also modulate the urinary risk profile and contribute to the risk of kidney stone formation. The assessment of nutritional risk factors is an essential component in the specific dietary therapy of kidney stone patients. An appropriate dietary intervention can contribute to the effective prevention of recurrent stones and reduce the burden of invasive surgical procedures for the treatment of urinary stone disease. This narrative review has intended to provide a comprehensive and updated overview on the role of nutrition and diet in kidney stone disease.

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“…An ideal, daily diet should consist of fruits and vegetables for magnesium, low calorie orange juice for citrate, and to be mindful of oxalate-rich food intake [46].…”

Section: Diet Nutrition Obesitymentioning

confidence: 99%

Is There an Association between Childhood Obesity and Pediatric Kidney Stone Disease? A Literature Review

Paiste

Moradi

Assimos

et al. 2021

Uro

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Objectives: To examine the most recent literature and published science in determining any and all possible associations between pediatric obesity and pediatric urolithiasis. Methods: Retrospective literature review of pediatric stone formers with diagnosed stone disease and all associated risk factors. Peer-reviewed, published manuscripts from the past several decades were analyzed for risk factors associated with pediatric obesity such as diet, hypertension, and renal diseases. Comparing the pediatric obesity literature with the pediatric stone forming literature, any associations and correlations were derived and analyzed. Results: Despite the existing evidence that obesity is linked to stones in adults, the evidence remains unclear whether obesity plays a role in children. Nutritional discrepancies, in the setting of the obesity epidemic, have been shown to alter the risk profile of pediatric patients. Consistent with the published literature, and lack of consistent correlation with obesity and stone disease, is the knowledge that age, gender, geography, and climate may all play a role in the onset of pediatric obesity and may also be on the causal pathway toward pediatric urolithiasis. Conclusion: The manuscript demonstrates that there are a number of risk factors, congenital or acquired, that are associated with pediatric obesity. The mechanisms responsible for these associations may be on the causal pathway toward childhood urolithiasis. These mechanisms that underlie these associations need to be further investigated.

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Using Low-Calorie Orange Juice as a Dietary Alternative to Alkali Therapy

Cited by 15 publications

References 18 publications

Role of Citrus Fruit Juices in Prevention of Kidney Stone Disease (KSD): A Narrative Review

Role of Citrus Fruit Juices in Prevention of Kidney Stone Disease (KSD): A Narrative Review

Nutrition and Kidney Stone Disease

Is There an Association between Childhood Obesity and Pediatric Kidney Stone Disease? A Literature Review

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