Using Magnetic Levitation for Three Dimensional Self‐Assembly

Mirica, Katherine A.; Ilievski, Filip; Ellerbee, Audrey K.; Shevkoplyas, Sergey S.; Whitesides, George M.

doi:10.1002/adma.201101917

Cited by 138 publications

(151 citation statements)

References 61 publications

Supporting

Mentioning

145

Contrasting

Unclassified

Order By: Relevance

“…Elegant experiments conducted by Whitesides et al have provided ample evidence that use of magnetic forces, such as in magnetic levitation, can guide the self-assembly of three-dimensional structures from even diamagnetic components [182,183].…”

Section: Solving the Intracellular Crowding And Molecular Self-assembmentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

View full text Add to dashboard Cite

This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the "problems" of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater "stiffness" in the extracellular matrix and either the "soft" cancerous state or the "soft" neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. OPEN ACCESSEntropy 2013, 15 3823

show abstract

Section: Solving the Intracellular Crowding And Molecular Self-assembmentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

View full text Add to dashboard Cite

show abstract

“…Finally, using magnetically functionalized electrospun matrices with magnetic nanoparticles [23] as well as using tissue spheroids biofabricated from cells labelled with magnetic nanoparticles [24][25][26][27] will enable the development of novel magnetic 3D bioprinting technology based on principles of magnetic levitation or translocation of tissue constructs using magnetic forces [28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that tissue spheroids can attach, spread and fuse on synthetic electrospun matrices [21,22] . Moreover, recently reported magnetic functionalization of electrospun synthetic matrices with magnetic nanoparticles [23] as well as biofabrication of tissue spheroids from cells labelled with magnetic nanoparticles [24][25][26][27] allow the development of magnetic forcesdriven biofabrication and even 3D magnetic bioprinting based on principles of magnetic levitation [28][29][30] . Thus, application of nanotechnology can enable development of novel technology of magnetic 3D bioprinting.…”

Section: Introductionmentioning

confidence: 99%

Patterning of tissue spheroids biofabricated from human fibroblasts on the surface of electrospun polyurethane matrix using 3D bioprinter

Mironov¹,

Khesuani²,

Буланова³

et al. 2024

IJB

View full text Add to dashboard Cite

Patterning of tissue spheroids biofabricated from human fibroblasts on the surface of electrospun polyurethane matrix using 3D bioprinter. © 2016 Elizabeth V. Koudan, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 45 RESEARCH ARTICLEPatterning of tissue spheroids biofabricated from human fibroblasts on the surface of electrospun polyurethane matrix using 3D bioprinter Abstract: Organ printing is a computer-aided additive biofabrication of functional three-dimensional human tissue and organ constructs according to digital model using the tissue spheroids as building blocks. The fundamental biological principle of organ printing technology is a phenomenon of tissue fusion. Closely placed tissue spheroids undergo tissue fusion driven by surface tension forces. In order to ensure tissue fusion in the course of post-printing, tissue spheroids must be placed and maintained close to each other. We report here that tissue spheroids biofabricated from primary human fibroblasts could be placed and maintained on the surface of biocompatible electrospun polyurethane matrix using 3D bioprinter according to desirable pattern. The patterned tissue spheroids attach to polyurethane matrix during several hours and became completely spread during several days. Tissue constructions biofabricated by spreading of patterned tissue spheroids on the biocompatible electrospun polyurethane matrix is a novel technological platform for 3D bioprinting of human tissue and organs.

show abstract

“…(Tesla) is the magnitude of the magnetic field at the surface of the magnets, g (m/s 2 ) is the acceleration due to gravity, and ! (T·m·A -1 ) is the magnetic permeability of free space.We and others have used MagLev to classify forensic evidence, [15] analyze biological systems, [16,17] determine the quality of food, [18] separate crystal polymorphs, [19] separate enantiomers and racemates, [20] and determine the environment used for self-assembly, [21] among other applications. [22][23][24][25][26][27][28][29][30][31] Recently, we used MagLev to orient and assemble objects in three dimensions without mechanical contact.…”

mentioning

confidence: 99%

Using Magnetic Levitation for Non‐Destructive Quality Control of Plastic Parts

et al. 2015

Self Cite

View full text Add to dashboard Cite

INTRODUCTIONLarge-scale, reliable, and economical manufacturing of plastic objects ("parts") [1] is critical for a range of industrial applications (e.g. medical devices, automotive parts, small consumer goods, micro-electro-mechanical systems (MEMS), and optical devices, among others). Plastic parts are chosen (over metal, for example) in many cases, in order to lower the cost (as well as weight, corrosion resistance, and other properties) of the final assembled product. Depending on the scale of manufacturing, costs favor relatively simple techniques such as injection molding, casting, stamping, or machining for producing products with a range of shapes from raw, polymeric plastics. [1] Low-cost plastic parts must maintain an acceptable level of quality to avoid failure in use. In an optimized production process, occasional defects, such as voids, cracks, or embedded impurities can occur during routine manufacturing. [2][3][4][5][6][7] Defective parts, if not identified, can lead to the failure of the final assembled product. Non-destructive methods are thus required to identify defective parts that deviate from quality standards resulting either from manufacturing (both process optimization and volume production) or improper storage or use of the part.Current non-destructive methods that have been used to test the quality of molded parts in specialized and critical applications include industrial computed tomography (ICT), [8,9] infrared thermography, [10] and ultrasonic testing. [11] The cost and complexity associated with the use of these instruments often prevent their application in routine quality control and, therefore, during the development and use of a manufacturing process, visual inspection may be the only form of quality control. In this paper, we demonstrate how magnetic levitation (MagLev) enables (i) the identification of parts with embedded defects, (ii) the separation of a defective part from a single batch, (iii) the characterization of certain kinds of defects, and (iv) the detection of counterfeit, high-value plastic parts. MagLev can suspend and orient [12] an object without contact by balancing gravitational and magnetic forces. [13] Here we show that the orientation of a part that is magnetically levitated depends strongly on both its shape and heterogeneity in density. This characteristic enables rapid identification of a defective part by visual inspection of the levitation height or angle of orientation in comparison to the rest of the parts in the batch. The method is inexpensive, non-destructive and straightforward to implement. The portability of the MagLev device has the potential to allow quality control of parts at the point-of-manufacturing, the pointof-sale, and the point-of-use.We used a similar MagLev device setup to those previously described. [13] Briefly, the object is suspended in a container filled with a paramagnetic solution (e.g., aqueous manganese chloride, MnCl 2 , or paramagnetic ionic liquids) [14] and the container is placed between two NdFeB magnets oriented w...

show abstract

Using Magnetic Levitation for Three Dimensional Self‐Assembly

Cited by 138 publications

References 61 publications

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Patterning of tissue spheroids biofabricated from human fibroblasts on the surface of electrospun polyurethane matrix using 3D bioprinter

Using Magnetic Levitation for Non‐Destructive Quality Control of Plastic Parts

Contact Info

Product

Resources

About